Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis

The Ribosome Biogenesis—Cancer Connection

(2019) Marianna Penzo et al.   Cells

Cancer Biogenesis in Ribosomopathies

(2019) Sergey Sulima et al.   Cells

Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome

(2019) Yi Zhou et al.   Nature Communications

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

(2019) Yu-Hua Lo et al.   Nature Communications

The AAA-ATPase MIDASIN 1 Functions in Ribosome Biogenesis and Is Essential for Embryo and Root Development

(2019) Peng-Cheng Li et al.   PLANT PHYSIOLOGY

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

(2019) Katherine E Bohnsack et al.   EMBO JOURNAL

Defining the RNA interactome by total RNA‐associated protein purification

(2019) Vadim Shchepachev et al.   Molecular Systems Biology

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

(2019) Blake W Tye et al.   eLife

Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

(2019) Vasileios Kargas et al.   eLife

A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

(2019) Benjamin Albert et al.   eLife

Inhibiting eukaryotic ribosome biogenesis

(2019) Dominik Awad et al.   BMC BIOLOGY

Using chemical inhibitors to probe AAA protein conformational dynamics and cellular functions

(2019) Jonathan B Steinman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Hallmarks of ribosomopathies

(2019) Kim R Kampen et al.   NUCLEIC ACIDS RESEARCH

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Ribosomopathies: Old Concepts, New Controversies

(2019) Katherine I. Farley-Barnes et al.   TRENDS IN GENETICS

Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin–ligand-type complexes

(2019) Yasar Luqman Ahmed et al.   Nature Communications

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs

(2019) Mahesh Lingaraju et al.   Nature Communications

Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

(2019) Han Han et al.   eLife

Arabidopsis MDN1 Is Involved in the Establishment of a Normal Seed Proteome and Seed Germination

(2019) Peng-Cheng Li et al.   Frontiers in Plant Science

WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2

(2018) Nobuhiro Hiraishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assembly and structure of the SSU processome — a nucleolar precursor of the small ribosomal subunit

(2018) Jonas Barandun et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Compound heterozygous SPATA5 variants in four families and functional studies of SPATA5 deficiency

(2018) Sanna Puusepp et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Hierarchical recruitment of ribosomal proteins and assembly factors remodels nucleolar pre-60S ribosomes

(2018) Stephanie Biedka et al.   JOURNAL OF CELL BIOLOGY

Modular assembly of the nucleolar pre-60S ribosomal subunit

(2018) Zahra Assur Sanghai et al.   NATURE

Structure of the nuclear exosome captured on a maturing preribosome

(2018) Jan Michael Schuller et al.   SCIENCE

Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate

(2018) Dejian Zhou et al.   Protein & Cell

NSF-mediated disassembly of on and off-pathway SNARE complexes and inhibition by complexin

(2018) Ucheor B Choi et al.   eLife

Ribosomal biogenesis as an emerging target of neurodevelopmental pathologies

(2018) Michal Hetman et al.   JOURNAL OF NEUROCHEMISTRY

Structural principles of SNARE complex recognition by the AAA+ protein NSF

(2018) K Ian White et al.   eLife

Eurokaryotic Ribosome Assembly

(2018) Jochen Baßler et al.   Annual Review of Biochemistry

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

(2018) Frédéric Catez et al.   BIOCHEMICAL PHARMACOLOGY

Hinge–Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity

(2018) Tristan A. Bell et al.   BIOCHEMISTRY

Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis

(2018) Zhen Chen et al.   CELL

Ribosome assembly coming into focus

(2018) Sebastian Klinge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation

(2018) Matthias Thoms et al.   Nature Communications

Maturation of pre‐40S particles in yeast and humans

(2018) Emilie Cerezo et al.   Wiley Interdisciplinary Reviews-RNA

The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1

(2018) Piotr Sosnowski et al.   eLife

Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors

(2017) John C. Zinder et al.   GENES & DEVELOPMENT

Eukaryotic ribosome assembly, transport and quality control

(2017) Cohue Peña et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control

(2017) Anshuk Sarkar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Viewing pre-60S maturation at a minute’s timescale

(2017) Gertrude Zisser et al.   NUCLEIC ACIDS RESEARCH

The assembly factor Erb1 functions in multiple remodeling events during 60S ribosomal subunit assembly inS. cerevisiae

(2017) Salini Konikkat et al.   NUCLEIC ACIDS RESEARCH

Insights into remodeling events during eukaryotic large ribosomal subunit assembly provided by high resolution cryo-EM structures

(2017) Stephanie Biedka et al.   RNA Biology

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2

(2017) Yu-Hua Lo et al.   STRUCTURE

A Puzzle of Life: Crafting Ribosomal Subunits

(2017) Dieter Kressler et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome

(2017) Lisa Fromm et al.   Nature Communications

Eukaryotic ribosome assembly, transport and quality control

(2017) Cohue Peña et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control

(2017) Anshuk Sarkar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved inter-domain communication mechanism regulates the ATPase activity of the AAA-protein Drg1

(2017) Michael Prattes et al.   Scientific Reports

Structure of a AAA+ unfoldase in the process of unfolding substrate

(2017) Zev A Ripstein et al.   eLife

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

(2017) Célia Deville et al.   Science Advances

The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease

(2016) A. Pelava et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Review: Structure and mechanism of the dynein motor ATPase

(2016) Helgo Schmidt et al.   BIOPOLYMERS

Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation

(2016) Basil Johannes Greber et al.   CELL

Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis

(2016) Shigehiro A. Kawashima et al.   CELL

Characterization of SPATA5 -related encephalopathy in early childhood

(2016) H. Kurata et al.   CLINICAL GENETICS

Structure and function of the AAA+ ATPase p97/Cdc48p

(2016) Di Xia et al.   GENE

Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF)

(2016) Minglei Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY

The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling

(2016) Nithya Raman et al.   MOLECULAR CELL

Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes

(2016) Shan Wu et al.   NATURE

The regulation and functions of the nuclear RNA exosome complex

(2016) Cornelia Kilchert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SPATA5 mutations cause a distinct autosomal recessive phenotype of intellectual disability, hypotonia and hearing loss

(2016) Rebecca Buchert et al.   Orphanet Journal of Rare Diseases

Assembly and trafficking of box C/D and H/ACA snoRNPs

(2016) Séverine Massenet et al.   RNA Biology

Mechanistic insight into eukaryotic 60S ribosomal subunit biogenesis by cryo-electron microscopy

(2016) Basil J. Greber   RNA

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97

(2016) Petra Hänzelmann et al.   STRUCTURE

Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain

(2016) Wai Kwan Tang et al.   Scientific Reports

Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss

(2015) Akemi J. Tanaka et al.   AMERICAN JOURNAL OF HUMAN GENETICS

AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74

(2015) Nobuhiro Hiraishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing

(2015) Yuki Yoshikatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins

(2015) Matthias Thoms et al.   CELL

The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer

(2015) S. G. Zhao et al.   CLINICAL CANCER RESEARCH

Ribosomopathies: how a common root can cause a tree of pathologies

(2015) Nadia Danilova et al.   Disease Models & Mechanisms

DEAD-box helicase DDX27 regulates 3′ end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex

(2015) Markus Kellner et al.   EXPERIMENTAL CELL RESEARCH

Control of p97 function by cofactor binding

(2015) Alexander Buchberger et al.   FEBS LETTERS

Chaperoning 5S RNA assembly

(2015) Clément Madru et al.   GENES & DEVELOPMENT

The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin

(2015) Erin M. Romes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

(2015) Adrian O. Olivares et al.   NATURE REVIEWS MICROBIOLOGY

Architecture of the Rix1–Rea1 checkpoint machinery during pre-60S-ribosome remodeling

(2015) Clara Barrio-Garcia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of eIF6 release from the nascent 60S ribosomal subunit

(2015) Félix Weis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes

(2015) Marcin Wegrecki et al.   NUCLEIC ACIDS RESEARCH

Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome biogenesis

(2015) Nozomi Asano et al.   NUCLEIC ACIDS RESEARCH

The structure of Rpf2–Rrs1 explains its role in ribosome biogenesis

(2015) Satyavati Kharde et al.   NUCLEIC ACIDS RESEARCH

Concerted removal of the Erb1–Ytm1 complex in ribosome biogenesis relies on an elaborate interface

(2015) Matthias Thoms et al.   NUCLEIC ACIDS RESEARCH

Altered cofactor regulation with disease-associated p97/VCP mutations

(2015) Xiaoyi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NVL gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population

(2015) Meng Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Architecture of the Rix1–Rea1 checkpoint machinery during pre-60S-ribosome remodeling

(2015) Clara Barrio-Garcia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of eIF6 release from the nascent 60S ribosomal subunit

(2015) Félix Weis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?

(2015) Elisa Brighenti et al.   Oncotarget

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

(2015) Qiaozhen Ye et al.   eLife

The Carboxy-Terminal Domain of Erb1 Is a Seven-Bladed ß-Propeller that Binds RNA

(2015) Wegrecki Marcin et al.   PLoS One

A new system for naming ribosomal proteins

(2014) Nenad Ban et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A hierarchical model for assembly of eukaryotic 60S ribosomal subunit domains

(2014) M. Gamalinda et al.   GENES & DEVELOPMENT

The mechanism of Torsin ATPase activation

(2014) Rebecca S. H. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle

(2014) Christoph Leidig et al.   Nature Communications

Processing of preribosomal RNA in Saccharomyces cerevisiae

(2014) Antonio Fernández-Pevida et al.   Wiley Interdisciplinary Reviews-RNA

The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1

(2013) Mathias Loibl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processive ATP-driven Substrate Disassembly by theN-Ethylmaleimide-sensitive Factor (NSF) Molecular Machine

(2013) Daniel J. Cipriano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors

(2013) Lionel Tafforeau et al.   MOLECULAR CELL

A nucleolar AAA-NTPase is required for parasite division

(2013) Elena S. Suvorova et al.   MOLECULAR MICROBIOLOGY

Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export

(2013) Yoshitaka Matsuo et al.   NATURE

Functions and mechanics of dynein motor proteins

(2013) Anthony J. Roberts et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Eukaryotic rpL10 drives ribosomal rotation

(2013) Sergey O. Sulima et al.   NUCLEIC ACIDS RESEARCH

The Role of the N-D1 Linker of the N-Ethylmaleimide-Sensitive Factor in the SNARE Disassembly

(2013) Cui-Cui Liu et al.   PLoS One

Mak5 and Ebp2 Act Together on Early Pre-60S Particles and Their Reduced Functionality Bypasses the Requirement for the Essential Pre-60S Factor Nsa1

(2013) Dagmar Pratte et al.   PLoS One

Quality control mechanisms during ribosome maturation

(2013) Katrin Karbstein   TRENDS IN CELL BIOLOGY

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

(2012) Hajime Niwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast Ribosomal Protein L40 Assembles Late into Precursor 60 S Ribosomes and Is Required for Their Cytoplasmic Maturation

(2012) Antonio Fernández-Pevida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturation

(2012) Lisa Kappel et al.   JOURNAL OF CELL BIOLOGY

The Conserved Bud20 Zinc Finger Protein Is a New Component of the Ribosomal 60S Subunit Export Machinery

(2012) J. Bassler et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear export

(2012) Martin Altvater et al.   Molecular Systems Biology

Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit

(2012) Basil J Greber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel

(2012) Bettina Bradatsch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission

(2012) C. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97

(2012) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronizing Nuclear Import of Ribosomal Proteins with Ribosome Assembly

(2012) D. Kressler et al.   SCIENCE

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

The power of AAA-ATPases on the road of pre-60S ribosome maturation — Molecular machines that strip pre-ribosomal particles

(2011) Dieter Kressler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex

(2011) Elisabeth Finkbeiner et al.   EMBO JOURNAL

A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease

(2011) Sander Granneman et al.   EMBO JOURNAL

Assembly ofSaccharomyces cerevisiae60S ribosomal subunits: role of factors required for 27S pre-rRNA processing

(2011) Aarti Sahasranaman et al.   EMBO JOURNAL

Structure and Function of the N-terminal Nucleolin Binding Domain of Nuclear Valosin-containing Protein-like 2 (NVL2) Harboring a Nucleolar Localization Signal

(2011) Yoshie Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

(2011) Christopher D. Castle et al.   MOLECULAR BIOLOGY OF THE CELL

The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA

(2011) Nicholas J. Watkins et al.   Wiley Interdisciplinary Reviews-RNA

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Pathway of Cytoplasmic Maturation of the 60S Ribosomal Subunit

(2010) Kai-Yin Lo et al.   MOLECULAR CELL

The AAA-ATPase Rea1 Drives Removal of Biogenesis Factors during Multiple Stages of 60S Ribosome Assembly

(2010) Jochen Baßler et al.   MOLECULAR CELL

A ‘garbage can’ for ribosomes: how eukaryotes degrade their ribosomes

(2010) Denis L.J. Lafontaine   TRENDS IN BIOCHEMICAL SCIENCES

The MIDASIN and NOTCHLESS genes are essential for female gametophyte development in Arabidopsis thaliana

(2010) Sier-Ching Chantha et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Driving ribosome assembly

(2009) Dieter Kressler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine

(2009) Steven E. Glynn et al.   CELL

Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits

(2009) Cornelia Ulbrich et al.   CELL

The Cytosolic J-protein, Jjj1, and Rei1 Function in the Removal of the Pre-60 S Subunit Factor Arx1

(2009) Alison E. Meyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yvh1 is required for a late maturation step in the 60S biogenesis pathway

(2009) Stefan Kemmler et al.   JOURNAL OF CELL BIOLOGY

Powering through ribosome assembly

(2009) B. S. Strunk et al.   RNA

An Afg2/Spaf-Related Cdc48-like AAA ATPase Regulates the Stability and Activity of the C. elegans Aurora B Kinase AIR-2

(2008) Todd R. Heallen et al.   DEVELOPMENTAL CELL

The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles

(2008) Dieter Kressler et al.   JOURNAL OF CELL BIOLOGY

Interactions among Ytm1, Erb1, and Nop7 Required for Assembly of the Nop7-Subcomplex in Yeast Preribosomes

(2008) Lan Tang et al.   MOLECULAR BIOLOGY OF THE CELL

The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA+ proteins

(2008) Xiaodong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The AAA+ superfamily of functionally diverse proteins

(2008) Jamie Snider et al.   GENOME BIOLOGY