2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
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Title
2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
Authors
Keywords
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Journal
SCIENCE
Volume 351, Issue 6275, Pages 871-875
Publisher
American Association for the Advancement of Science (AAAS)
Online
2016-01-29
DOI
10.1126/science.aad7974
References
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- Sorafenib-Mediated Targeting of the AAA+ ATPase p97/VCP Leads to Disruption of the Secretory Pathway, Endoplasmic Reticulum Stress, and Hepatocellular Cancer Cell Death
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- Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
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- Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change
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