Roles of the N domain of the AAA+ Lon protease in substrate recognition, allosteric regulation and chaperone activity

Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine

(2013) Benjamin M. Stinson et al.   CELL

Regulated proteolysis of a transcription factor complex is critical to cell cycle progression inCaulobacter crescentus

(2013) Kasia G. Gora et al.   MOLECULAR MICROBIOLOGY

Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

(2013) E. F. Vieux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering fluorescent protein substrates for the AAA+ Lon protease

(2013) M. L. Wohlever et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

(2012) S. H. Bernstein et al.   BLOOD

Identification of a Region in the N-Terminus of Escherichia coli Lon That Affects ATPase, Substrate Translocation and Proteolytic Activity

(2012) Iteen Cheng et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine

(2012) Steven E Glynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biological Roles of the Podospora anserina Mitochondrial Lon Protease and the Importance of Its N-Domain

(2012) Céline Adam et al.   PLoS One

The Lon Protease Is Essential for Full Virulence in Pseudomonas aeruginosa

(2012) Elena B. M. Breidenstein et al.   PLoS One

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Stepwise Unfolding of a β Barrel Protein by the AAA+ ClpXP Protease

(2011) Andrew R. Nager et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein unfolding and degradation by the AAA+ Lon protease

(2011) Eyal Gur et al.   PROTEIN SCIENCE

Structure of the N-terminal fragment ofEscherichia coliLon protease

(2010) Mi Li et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber

(2010) Sun-Shin Cha et al.   EMBO JOURNAL

Crystal Structures of Bacillus subtilis Lon Protease

(2010) Ramona E. Duman et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Folding in the Cytoplasm and the Heat Shock Response

(2010) R. M. Vabulas et al.   Cold Spring Harbor Perspectives in Biology

Increasing organismal healthspan by enhancing mitochondrial protein quality control

(2009) Karin Luce et al.   NATURE CELL BIOLOGY

Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine

(2009) E. Gur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteases in bacterial pathogenesis

(2009) Hanne Ingmer et al.   RESEARCH IN MICROBIOLOGY

Evidence That Two ATP-Dependent (Lon) Proteases in Borrelia burgdorferi Serve Different Functions

(2009) James L. Coleman et al.   PLoS Pathogens

Recognition of misfolded proteins by Lon, a AAA+ protease

(2008) E. Gur et al.   GENES & DEVELOPMENT

Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY