Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy

Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains

(2017) Chao Liu et al.   Nature Communications

Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants

(2017) Ting Zhang et al.   eLife

A Rapid and Versatile Method for Generating Proteins with Defined Ubiquitin Chains

(2016) Kirby Martinez-Fonts et al.   BIOCHEMISTRY

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited

(2016) Jan M. Schuller et al.   FEBS LETTERS

Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor

(2016) Liang Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions

(2016) Petra Hänzelmann et al.   STRUCTURE

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97

(2016) Petra Hänzelmann et al.   STRUCTURE

Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain

(2016) Wai Kwan Tang et al.   Scientific Reports

Valosin-containing protein (VCP/p97) is capable of unfolding polyubiquitinated proteins through its ATPase domains

(2015) Changcheng Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100

(2015) Zhao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Systematic proteomics of the VCP–UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis

(2015) Malavika Raman et al.   NATURE CELL BIOLOGY

Altered cofactor regulation with disease-associated p97/VCP mutations

(2015) Xiaoyi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

The p97-FAF1 Protein Complex Reveals a Common Mode of p97 Adaptor Binding

(2014) Caroline A. Ewens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase Domains

(2014) Tsui-Fen Chou et al.   JOURNAL OF MOLECULAR BIOLOGY

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy

(2014) H. O. Yeung et al.   Open Biology

Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation

(2013) Zhao Zhang et al.   DEVELOPMENTAL CELL

Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

(2013) Wai Kwan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20Speptidase

(2013) Dominik Barthelme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

(2013) Q. Defenouillere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation

(2012) Susanne Bandau et al.   BMC BIOLOGY

mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy

(2012) J. K. Ching et al.   HUMAN MOLECULAR GENETICS

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

(2012) Hajime Niwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

(2012) Willem den Besten et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97

(2012) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy

(2012) C. Bebeacua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Cdc48bullet20S Proteasome as an Ancient AAA+ Proteolytic Machine

(2012) D. Barthelme et al.   SCIENCE

The Cdc48 machine in endoplasmic reticulum associated protein degradation

(2011) Dieter H. Wolf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The p97 ATPase associates with EEA1 to regulate the size of early endosomes

(2011) Harish N Ramanathan et al.   CELL RESEARCH

Positive Cooperativity of the p97 AAA ATPase Is Critical for Essential Functions

(2011) Shingo Nishikori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM)

(2011) Petra Hänzelmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Yield Expression in Escherichia coli and Purification of Mouse Ubiquitin-Activating Enzyme E1

(2011) Andreia F. Carvalho et al.   MOLECULAR BIOTECHNOLOGY

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

(2011) Danilo Ritz et al.   NATURE CELL BIOLOGY

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

Preparation of Distinct Ubiquitin Chain Reagents of High Purity and Yield

(2011) Ken C. Dong et al.   STRUCTURE

Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model

(2011) Ya-Chu Chang et al.   PLoS Genetics

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97This paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

(2010) Masatoshi Esaki et al.   Biochemistry and Cell Biology

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

(2010) Wai Kwan Tang et al.   EMBO JOURNAL

Imbalances in p97 co-factor interactions in human proteinopathy

(2010) Vanesa Fernández-Sáiz et al.   EMBO REPORTS

Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy

(2010) J. S. Ju et al.   HUMAN MOLECULAR GENETICS

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

(2010) G. P. Ritson et al.   JOURNAL OF NEUROSCIENCE

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

(2010) Shan Xu et al.   MOLECULAR BIOLOGY OF THE CELL

The complexities of p97 function in health and disease

(2010) Eli Chapman et al.   Molecular BioSystems

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

A Conserved Unfoldase Activity for the p97 AAA-ATPase in Proteasomal Degradation

(2009) Anne Beskow et al.   JOURNAL OF MOLECULAR BIOLOGY

Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation

(2009) D. Halawani et al.   MOLECULAR AND CELLULAR BIOLOGY

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

(2008) C. Schuberth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase

(2008) Louise C. Briggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE