cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

A direct proofreader–clamp interaction stabilizes the Pol III replicase in the polymerization mode

(2013) Slobodan Jergic et al.   EMBO JOURNAL

Architecture of the Pol III–clamp–exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair

(2013) Ana Toste Rêgo et al.   EMBO JOURNAL

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli

(2013) Amit Sharma et al.   NUCLEIC ACIDS RESEARCH

Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain

(2013) Kiyoshi Ozawa et al.   NUCLEIC ACIDS RESEARCH

Cycling of the E. coli lagging strand polymerase is triggered exclusively by the availability of a new primer at the replication fork

(2013) Quan Yuan et al.   NUCLEIC ACIDS RESEARCH

Structure of the PolIIIα-τc-DNA Complex Suggests an Atomic Model of the Replisome

(2013) Bin Liu et al.   STRUCTURE

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

The Rate of Polymerase Release upon Filling the Gap between Okazaki Fragments Is Inadequate to Support Cycling during Lagging Strand Synthesis

(2011) Paul R. Dohrmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein induced fluorescence enhancement as a single molecule assay with short distance sensitivity

(2011) H. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of the DNA polymerase B-proliferating cell nuclear antigen (PCNA)-DNA ternary complex

(2011) Kouta Mayanagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Insight into Translesion Synthesis by DNA Pol II

(2009) Feng Wang et al.   CELL

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

(2009) Kyle R. Simonetta et al.   CELL

Mechanism of polymerase collision release from sliding clamps on the lagging strand

(2009) Roxana E Georgescu et al.   EMBO JOURNAL

Single molecule measurement of the "speed limit" of DNA polymerase

(2009) J. J. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase

(2009) C. Indiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression

(2009) N. Y. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Sliding Clamp on DNA

(2008) Roxana E. Georgescu et al.   CELL

Insights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III α-Subunit

(2008) Richard A. Wing et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp

(2008) R. E. Georgescu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of PolC reveals unique DNA binding and fidelity determinants

(2008) R. J. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA