Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia

Torsin ATPases: structural insights and functional perspectives

(2016) Ethan Laudermilch et al.   CURRENT OPINION IN CELL BIOLOGY

Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum

(2015) R. E. Goodchild et al.   JOURNAL OF CELL SCIENCE

The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1

(2015) Elizabeth M. Turner et al.   JOURNAL OF VIROLOGY

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

(2015) Adrian O. Olivares et al.   NATURE REVIEWS MICROBIOLOGY

Phenotype of non-c.907_909delGAG mutations in TOR1A: DYT1 dystonia revisited

(2015) Valerija Dobričić et al.   PARKINSONISM & RELATED DISORDERS

Unraveling Cellular Phenotypes of NovelTorsinA/TOR1AMutations

(2014) Franca Vulinovic et al.   HUMAN MUTATION

TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration

(2014) Chun-Chi Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined occurrence of a novelTOR1Aand aTHAP1mutation in primary dystonia

(2014) Fu-Bo Cheng et al.   MOVEMENT DISORDERS

Putting a finger in the ring

(2014) John McCullough et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutation in TOR1AIP1 encoding LAP1B in a form of muscular dystrophy: A novel gene related to nuclear envelopathies

(2014) Gulsum Kayman-Kurekci et al.   NEUROMUSCULAR DISORDERS

Severe dystonia, cerebellar atrophy, and cardiomyopathy likely caused by a missense mutation in TOR1AIP1

(2014) Imen Dorboz et al.   Orphanet Journal of Rare Diseases

The mechanism of Torsin ATPase activation

(2014) Rebecca S. H. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How lamina-associated polypeptide 1 (LAP1) activates Torsin

(2014) Brian A Sosa et al.   eLife

Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor

(2014) Cathleen Zeymer et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Regulation of Torsin ATPases by LAP1 and LULL1

(2013) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OptimizedE. coliexpression strain LOBSTR eliminates common contaminants from His-tag purification

(2013) Kasper R. Andersen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Torsin Mediates Primary Envelopment of Large Ribonucleoprotein Granules at the Nuclear Envelope

(2013) Vahbiz Jokhi et al.   Cell Reports

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TorsinA participates in endoplasmic reticulum-associated degradation

(2011) Flávia C. Nery et al.   Nature Communications

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

(2010) Alessandra Granata et al.   EMBO JOURNAL

The role of torsinA in dystonia

(2010) A. Granata et al.   EUROPEAN JOURNAL OF NEUROLOGY

A Unique Redox-sensing Sensor II Motif in TorsinA Plays a Critical Role in Nucleotide and Partner Binding

(2010) Li Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

(2010) C. E. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA

(2009) M. Jungwirth et al.   HUMAN MOLECULAR GENETICS

Interaction of TorsinA with Its Major Binding Partners Is Impaired by the Dystonia-associated ΔGAG Deletion

(2009) Teresa V. Naismith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia

(2009) N. Calakos et al.   JOURNAL OF MEDICAL GENETICS

LULL1 Retargets TorsinA to the Nuclear Envelope Revealing an Activity That Is Impaired by the DYT1 Dystonia Mutation

(2009) Abigail B. Vander Heyden et al.   MOLECULAR BIOLOGY OF THE CELL

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton

(2008) F. C. Nery et al.   JOURNAL OF CELL SCIENCE

Novel TOR1A mutation p.Arg288Gln in early-onset dystonia (DYT1)

(2008) B Zirn et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Torsin-family AAA+ Protein OOC-5 Contains a Critical Disulfide Adjacent to Sensor-II That Couples Redox State to Nucleotide Binding

(2008) Li Zhu et al.   MOLECULAR BIOLOGY OF THE CELL

The pathophysiological basis of dystonias

(2008) Xandra O. Breakefield et al.   NATURE REVIEWS NEUROSCIENCE

SUSCEPTIBILITY TO DYT1 DYSTONIA IN EUROPEAN PATIENTS IS MODIFIED BY THE D216H POLYMORPHISM

(2008) C. Kamm et al.   NEUROLOGY