Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Enzymatic Late‐Stage Modifications: Better Late than Never

(2021) Elvira Romero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds

(2021) Micol Santi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Power of Biocatalysis for Organic Synthesis

(2021) Christoph K. Winkler et al.   ACS Central Science

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

(2021) William Finnigan et al.   Nature Catalysis

Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction

(2021) Michael Burns et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent trends in the stereoselective synthesis of (poly)-substituted 2-oxo acids by biocatalyzed aldol reaction

(2021) Mathias Pickl   Current Opinion in Green and Sustainable Chemistry

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**

(2021) Ashley P. Mattey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalytic approaches for the synthesis of optically pure vic-halohydrins

(2021) Feng Xue et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

(2021) Grace P. Ahlqvist et al.   ACS Omega

Directed Evolution: Methodologies and Applications

(2021) Yajie Wang et al.   CHEMICAL REVIEWS

Practical Enzymatic Production of Carbocycles

(2021) Weijin Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzyme evolution for industrial biocatalytic cascades

(2021) Jovana Nazor et al.   CURRENT OPINION IN BIOTECHNOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

Identification and Expression of New Unspecific Peroxygenases – Recent Advances, Challenges and Opportunities

(2021) Alina Kinner et al.   Frontiers in Bioengineering and Biotechnology

Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor

(2021) Rajesh Kumar et al.   Nature Catalysis

Enzyme engineering for biosynthetic cascades

(2021) John A. McIntosh et al.   Current Opinion in Green and Sustainable Chemistry

Accelerated Reaction Engineering of Photo(bio)catalytic Reactions through Parallelization with an Open‐Source Photoreactor

(2021) Christoph Winkler et al.   ChemPhotoChem

New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases

(2021) Jon Del Arco et al.   BIOTECHNOLOGY ADVANCES

Efficient Nicotinamide Adenine Dinucleotide Phosphate [NADP(H)] Recycling in Closed‐Loop Continuous Flow Biocatalysis

(2020) Benedikt Baumer et al.   ADVANCED SYNTHESIS & CATALYSIS

Impact and relevance of alcohol dehydrogenase enantioselectivities on biotechnological applications

(2020) Afifa Ayu Koesoema et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

(2020) Birgit Wiltschi et al.   BIOTECHNOLOGY ADVANCES

Combination therapies currently under investigation in phase I and phase II clinical trials for HIV-1

(2020) Hanh Thi Pham et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Carnitine in Human Muscle Bioenergetics: Can Carnitine Supplementation Improve Physical Exercise?

(2020) Antonio Gnoni et al.   MOLECULES

Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose

(2020) Christopher C. Nawrat et al.   ORGANIC LETTERS

Engineering new catalytic activities in enzymes

(2020) Kai Chen et al.   Nature Catalysis

Enzymatic reductions ‐ A Chemist's perspective

(2020) Frank Hollmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesizing Chiral Drug Intermediates by Biocatalysis

(2020) Wei Jiang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Near-perfect kinetic resolution of o-methylphenyl glycidyl ether by RpEH, a novel epoxide hydrolase from Rhodotorula paludigena JNU001 with high stereoselectivity

(2020) Xiong-Feng Xu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis

(2020) Rebecca Roddan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biocatalysis in drug discovery and development

(2020) Anna Fryszkowska et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The never ending success story of tranexamic acid in acquired bleeding

(2020) Massimo Franchini et al.   HAEMATOLOGICA

Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696

(2020) Xingxian Gu et al.   JOURNAL OF ORGANIC CHEMISTRY

Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels

(2020) Na Xu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships

(2020) Sarah L. Montgomery et al.   Science Advances

Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia

(2020) Yvette N. Lamb   American Journal of Cardiovascular Drugs

Biocatalysis: Enzymatic Synthesis for Industrial Applications

(2020) Shuke Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Current and emerging drug treatment strategies for peripheral arterial disease

(2020) Hani Essa et al.   EXPERT OPINION ON PHARMACOTHERAPY

Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone

(2020) Niki R. Patel et al.   ORGANIC LETTERS

Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity

(2020) Giovanna Di Nardo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Embracing Nature’s Catalysts: A Viewpoint on the Future of Biocatalysis

(2020) Bernhard Hauer   ACS Catalysis

Broadening the scope of biocatalytic C–C bond formation

(2020) Lara E. Zetzsche et al.   Nature Reviews Chemistry

NAD(P)H‐Dependent Enzymes for Reductive Amination: Active Site Description and Carbonyl‐Containing Compound Spectrum

(2020) Laurine Ducrot et al.   ADVANCED SYNTHESIS & CATALYSIS

Unlocking Nature's Biosynthetic Power—Metabolic Engineering for the Fermentative Production of Chemicals

(2020) Birgit Hoff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent developments in the use of peroxygenases – Exploring their high potential in selective oxyfunctionalisations

(2020) Markus Hobisch et al.   BIOTECHNOLOGY ADVANCES

Efficient production of an ezetimibe intermediate using carbonyl reductase coupled with glucose dehydrogenase

(2020) Xiao‐Jian Zhang et al.   BIOTECHNOLOGY PROGRESS

Photobiocatalytic cascades: combining chemical and enzymatic transformations fueled by light

(2020) Fatma Feyza Özgen et al.   CHEMBIOCHEM

Variants of the Acyltransferase from Mycobacterium smegmatis Enable Enantioselective Acyl Transfer in Water

(2020) Etta Jost et al.   ACS Catalysis

Current state and future perspectives of engineered and artificial peroxygenases for the oxyfunctionalization of organic molecules

(2020) Marie-Cathérine Sigmund et al.   Nature Catalysis

Process Development toward a Pro-Drug of R-Baclofen

(2020) Glyn L. Allsop et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An innovative route for the production of atorvastatin side-chain precursor by DERA-catalysed double aldol addition

(2020) Anera Švarc et al.   CHEMICAL ENGINEERING SCIENCE

A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia

(2019) Pitchai Balakumar et al.   Current Molecular Pharmacology

Biocatalyzed Synthesis of Statins: A Sustainable Strategy for the Preparation of Valuable Drugs

(2019) Pilar Hoyos et al.   Catalysts

Cytochrome P450 Monooxygenases in Biotechnology and Synthetic Biology

(2019) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

Structural insights into alcohol dehydrogenases catalyzing asymmetric reductions

(2019) Jianhong An et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

P450 Monooxygenases Enable Rapid Late-Stage Diversification of Natural Products via C−H Bond Activation

(2019) Nico D. Fessner   ChemCatChem

Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives

(2019) Matthias Engleder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Cyanation Reactions of Aldehydes and Ketones in Total Syntheses

(2019) Xing-Ping Zeng et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalysis: A Pharma Perspective

(2019) Joseph P. Adams et al.   ADVANCED SYNTHESIS & CATALYSIS

The Promises and the Challenges of Biotransformations in Microflow

(2019) Polona Žnidaršič‐Plazl   Biotechnology Journal

Clopidogrel Pharmacogenetics

(2019) Naveen L. Pereira et al.   Circulation-Cardiovascular Interventions

Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study

(2019) Amin Bornadel et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

(2019) Ge Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Tailor-Made Self-Sufficient Whole-Cell Biocatalyst Enables Scalable Enantioselective Synthesis of (R)-3-Quinuclidinol in a High Space-Time Yield

(2019) Qian Chen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis

(2019) Margery Cortes-Clerget et al.   Nature Communications

Efficient Chemoenzymatic Synthesis of Optically Active Pregabalin from Racemic Isobutylsuccinonitrile

(2019) Qin Zhang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019)

(2019) Pablo Domínguez de María et al.   Catalysts

Ultrahigh-throughput screening enables efficient single-round oxidase remodelling

(2019) Aaron Debon et al.   Nature Catalysis

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

(2019) Markus Schober et al.   Nature Catalysis

Stereodivergent Synthesis of 3‐Hydroxyprolines and 3‐Hydroxypipecolic Acids via Ketoreductase‐Catalyzed Dynamic Kinetic Reduction

(2019) Christopher K. Prier et al.   ADVANCED SYNTHESIS & CATALYSIS

Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)

(2019) Frances H. Arnold   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cofactor F420-Dependent Enzymes: An Under-Explored Resource for Asymmetric Redox Biocatalysis

(2019) Mihir V. Shah et al.   Catalysts

Third-generation epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer

(2019) Natalie M. Andrews Wright et al.   Translational Lung Cancer Research

Engineering imine reductases for industrial applications

(2019) Matthias Höhne   Nature Catalysis

Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase

(2019) Xi Chen et al.   Nature Catalysis

Highly Efficient Access to ( S )‐Sulfoxides Utilizing a Promiscuous Flavoprotein Monooxygenase in a Whole‐Cell Biocatalyst Format

(2019) Christian Willrodt et al.   ChemCatChem

Chemoenzymatic Synthesis of Sertraline

(2019) Lisa Marx et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

LSD1/KDM1A inhibitors in clinical trials: advances and prospects

(2019) Yuan Fang et al.   Journal of Hematology & Oncology

Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis

(2019) Russell D. Cink et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Islatravir for the treatment and prevention of infection with the human immunodeficiency virus type 1

(2019) Martin Markowitz et al.   Current Opinion in HIV and AIDS

Mechanisms of suppression of cell growth by dual inhibition of ALK and MEK in ALK-positive non-small cell lung cancer

(2019) N. Shrestha et al.   Scientific Reports

Industrial applications of immobilized enzymes—A review

(2019) Alessandra Basso et al.   Molecular Catalysis

Protein immobilization technology for flow biocatalysis

(2019) María Romero-Fernández et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biocatalytic Oxidation Reactions: A Chemist's Perspective

(2018) JiaJia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates

(2018) Huihua Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biocatalysis for synthesis of pharmaceuticals

(2018) Ramesh N. Patel   BIOORGANIC & MEDICINAL CHEMISTRY

Sequence-Based In-silico Discovery, Characterisation, and Biocatalytic Application of a Set of Imine Reductases

(2018) Stefan Velikogne et al.   ChemCatChem

The limits to biocatalysis: pushing the envelope

(2018) Roger A. Sheldon et al.   CHEMICAL COMMUNICATIONS

Chiral sulfoxides: advances in asymmetric synthesis and problems with the accurate determination of the stereochemical outcome

(2018) Jianlin Han et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of chiral amines using redox biocatalysis

(2018) Gideon Grogan   CURRENT OPINION IN CHEMICAL BIOLOGY

Biocatalytic reduction of activated C C-bonds and beyond: emerging trends

(2018) Christoph K Winkler et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Baeyer–Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation

(2018) Yong Koy Bong et al.   JOURNAL OF ORGANIC CHEMISTRY

Identification and Implementation of Biocatalytic Transformations in Route Discovery: Synthesis of Chiral 1,3-Substituted Cyclohexanone Building Blocks

(2018) Timin Hadi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Microbial biotransformation of bioactive and clinically useful steroids and some salient features of steroids and biotransformation

(2018) Nighat Sultana   STEROIDS

Discovery, Characterization, Engineering, and Applications of Ene-Reductases for Industrial Biocatalysis

(2018) Helen S. Toogood et al.   ACS Catalysis

l-Carnitine Supplementation in Recovery after Exercise

(2018) Roger Fielding et al.   Nutrients

Role of carnitine and its derivatives in the development and management of type 2 diabetes

(2018) Judit Bene et al.   Nutrition & Diabetes

New Insights on Steroid Biotechnology

(2018) Lorena Fernández-Cabezón et al.   Frontiers in Microbiology

Industrial Applications of Enzymes: Recent Advances, Techniques, and Outlooks

(2018) Jordan Chapman et al.   Catalysts

Artificial Biocatalytic Linear Cascades to Access Hydroxy Acids, Lactones, and α- and β-Amino Acids

(2018) Joerg Schrittwieser et al.   Catalysts

Enzymatic Cascade Reactions in Biosynthesis

(2018) Christopher T. Walsh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Extending Designed Linear Biocatalytic Cascades for Organic Synthesis

(2018) Somayyeh Gandomkar et al.   ChemCatChem

Enantio- and regioselective ene-reductions using F420H2-dependent enzymes

(2018) Sam Mathew et al.   CHEMICAL COMMUNICATIONS

Biocatalysis in Drug Development—Highlights of the Recent Patent Literature

(2018) David L. Hughes   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Mechanoenzymatic resolution of racemic chiral amines, a green technique for the synthesis of pharmaceutical building blocks

(2018) Mario Pérez-Venegas et al.   TETRAHEDRON

High Throughput Strategies for the Discovery and Optimization of Catalytic Reactions

(2018) Eric S. Isbrandt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2-Deoxy-d-ribose-5-phosphate aldolase (DERA): applications and modifications

(2018) Meera Haridas et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Interconnection of sulfides and sulfoxides in medicinal chemistry

(2018) Abdrrahman Shemsu Surur et al.   ARCHIV DER PHARMAZIE

Highly efficient conversion of 1-cyanocycloalkaneacetonitrile using a “super nitrilase mutant”

(2018) Zhe Xu et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Development, optimization and scale-up of stereo-selective enzymatic Baeyer–Villiger oxidation of pyrmetazole to esomeprazole active ingredient in an industrial-scale slurry reactor

(2018) Marko Herga et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Regioselective Biocatalytic Transformations Employing Transaminases and Tyrosine Phenol Lyases

(2018) Lía Martínez-Montero et al.   TOPICS IN CATALYSIS

Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor

(2018) Xu-Min Gong et al.   ACS Catalysis

Mechanistic Studies of Fatty Acid Activation by CYP152 Peroxygenases Reveal Unexpected Desaturase Activity

(2018) Mathias Pickl et al.   ACS Catalysis

Oxidoreductase-Catalyzed Synthesis of Chiral Amines

(2018) Mahesh D. Patil et al.   ACS Catalysis

Extending the application of biocatalysis to meet the challenges of drug development

(2018) Paul N. Devine et al.   Nature Reviews Chemistry

Recent preparative applications of redox enzymes

(2018) Christopher K Prier et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity

(2018) Ruijie K Zhang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

(2017) P. Matzel et al.   GREEN CHEMISTRY

Asymmetric Biocatalytic Reduction of Cyclic Imines: Design and Application of a Tailor-Made Whole-Cell Catalyst

(2017) Harald Gröger et al.   HETEROCYCLES

An Overview on the Enhancement of Enantioselectivity and Stability of Microbial Epoxide Hydrolases

(2017) Priya Saini et al.   MOLECULAR BIOTECHNOLOGY

Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids

(2017) Mathias Pickl et al.   MOLECULES

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function

(2017) Jeffrey D. Rudolf et al.   NATURAL PRODUCT REPORTS

Spatial organization of multi-enzyme biocatalytic cascades

(2017) M. B. Quin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization

(2017) Mark McLaughlin et al.   ORGANIC LETTERS

A Chemoenzymatic Route to Chiral Intermediates Used in the Multikilogram Synthesis of a Gamma Secretase Inhibitor

(2017) Michael Burns et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Practical Enzymatic Process for Preparation of (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

(2017) Xiang Guo et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of an Efficient and Scalable Biocatalytic Route to (3R)-3-Aminoazepane: A Pharmaceutically Important Intermediate

(2017) Yahui Feng et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development and Scale-up of a Biocatalytic Process To Form a Chiral Sulfoxide

(2017) William R. F. Goundry et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Patent Review of Manufacturing Routes to Recently Approved PARP Inhibitors: Olaparib, Rucaparib, and Niraparib

(2017) David L. Hughes   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a practical biocatalytic process for ( S )- N -Boc-3-hydroxypiperidine synthesis

(2017) Li-Feng Chen et al.   TETRAHEDRON LETTERS

Old Yellow Enzyme-Catalysed Asymmetric Hydrogenation: Linking Family Roots with Improved Catalysis

(2017) Anika Scholtissek et al.   Catalysts

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

(2016) Veit Weichold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single mutations of ketoreductase ChKRED20 enhance the bioreductive production of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol

(2016) Feng-Jiao Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Arylmalonate decarboxylase—a highly selective bacterial biocatalyst with unknown function

(2016) Kenji Miyamoto et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent advances on halohydrin dehalogenases—from enzyme identification to novel biocatalytic applications

(2016) Anett Schallmey et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Highly engineered biocatalysts for efficient small molecule pharmaceutical synthesis

(2016) Jim Lalonde   CURRENT OPINION IN BIOTECHNOLOGY

Some of tomorrow's catalysts for processing renewable and non-renewable feedstocks, diminishing anthropogenic carbon dioxide and increasing the production of energy

(2016) John Meurig Thomas et al.   Energy & Environmental Science

Stereoselective Enzymatic Reduction of Ethyl Secodione: Preparation of a Key Intermediate for the Total Synthesis of Steroids

(2016) Martina Letizia Contente et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Thiamine-Diphosphate-Dependent Enzymes as Catalytic Tools for the Asymmetric Benzoin-Type Reaction

(2016) Pier Paolo Giovannini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Updating and further expanding GSK's solvent sustainability guide

(2016) Catherine M. Alder et al.   GREEN CHEMISTRY

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Enzymatic reactions in confined environments

(2016) Andreas Küchler et al.   Nature Nanotechnology

Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases – a review

(2016) Paula Bracco et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enabling Selective and Sustainable P450 Oxygenation Technology. Production of 4-Hydroxy-α-isophorone on Kilogram Scale

(2016) Iwona Kaluzna et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Efficient bioreductive production of (S)-N-Boc-3-hydroxypiperidine using ketoreductase ChKRED03

(2016) Guang-Peng Xu et al.   PROCESS BIOCHEMISTRY

Identification of a novel oxygenase capable of regiospecific hydroxylation of d-limonene into (+)-trans-carveol

(2016) M. Groeneveld et al.   TETRAHEDRON

Stereoselective synthetic approaches towards (S)-duloxetine: 2000 to date

(2016) Fayaz Ali Larik et al.   TETRAHEDRON-ASYMMETRY

Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products

(2016) Nina G. Schmidt et al.   ACS Catalysis

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

(2016) Scott P. France et al.   ACS Catalysis

Biocatalytic Imine Reduction and Reductive Amination of Ketones

(2015) Joerg H. Schrittwieser et al.   ADVANCED SYNTHESIS & CATALYSIS

Protein Engineering of a Nitrilase from Burkholderia cenocepacia J2315 for Efficient and Enantioselective Production of (R)-o-Chloromandelic Acid

(2015) Hualei Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Chemoenzymatic synthesis of rasagiline mesylate using lipases

(2015) Thiago de Sousa Fonseca et al.   APPLIED CATALYSIS A-GENERAL

The substrate tolerance of alcohol oxidases

(2015) Mathias Pickl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents

(2015) Seyedeh Mahdieh Hashemi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biocatalysis for desymmetrization and resolution of stereocenters beyond the reactive center: How far is far enough?

(2015) Rodrigo L.O.R. Cunha et al.   BIOTECHNOLOGY ADVANCES

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space

(2015) Dennis Wetzl et al.   CHEMBIOCHEM

Cascade catalysis – strategies and challenges en route to preparative synthetic biology

(2015) Jan Muschiol et al.   CHEMICAL COMMUNICATIONS

Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation

(2015) Gheorghe-Doru Roiban et al.   CHEMICAL COMMUNICATIONS

The Industrial Age of Biocatalytic Transamination

(2015) Michael Fuchs et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

An Enantioselective Formal Synthesis of Montelukast Sodium

(2015) Satyanarayana Bollikonda et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of EFdA via a Diastereoselective Aldol Reaction of a Protected 3-Keto Furanose

(2015) Kei Fukuyama et al.   ORGANIC LETTERS

Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block

(2015) Richard Metzner et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of an Immobilized Ketoreductase for Enzymatic (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol Production

(2015) Hongmei Li et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Two-Step, Enantioselective Synthesis of an Amino Alcohol Drug Candidate

(2015) Michael A. Schmidt et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Preparation of β-hydroxy-α-amino Acid Using Recombinant d-Threonine Aldolase

(2015) Steven L. Goldberg et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming ofPenicillium chrysogenum

(2015) Kirsty J. McLean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific oxyfunctionalisations catalysed by peroxygenases: opportunities, challenges and solutions

(2015) Sebastian Bormann et al.   Catalysis Science & Technology

Benefits, limits and danger of ephedrine and pseudoephedrine as nasal decongestants

(2015) O. Laccourreye et al.   European Annals of Otorhinolaryngology-Head and Neck Diseases

Concise Synthesis of the Anti-HIV Nucleoside EFdA

(2015) Masayuki KAGEYAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells

(2015) Kathleen A. Bridges et al.   Oncotarget

Cutting Short the Asymmetric Synthesis of the Ramatroban Precursor by Employing ω-Transaminases

(2014) Eduardo Busto et al.   ADVANCED SYNTHESIS & CATALYSIS

Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases

(2014) Christoph K. Winkler et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Allylation of Thiophene-2-carbaldehyde: Formal Total Synthesis of Duloxetine

(2014) Petr Motloch et al.   ADVANCED SYNTHESIS & CATALYSIS

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

(2014) Rita Bernhardt et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Efficient production of ethyl (R)-2-hydroxy-4-phenylbutyrate using a cost-effective reductase expressed in Pichia pastoris

(2014) Xiao-Long Qian et al.   BIOCHEMICAL ENGINEERING JOURNAL

Bioreductions Catalyzed by an Alcohol Dehydrogenase in Non-aqueous Media

(2014) Selin Kara et al.   ChemCatChem

New developments in ‘ene’-reductase catalysed biological hydrogenations

(2014) Helen S Toogood et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Comprehensive mass analysis for chemical processes, a case study on l-Dopa manufacture

(2014) Tao Li et al.   GREEN CHEMISTRY

Pregabalin’s abuse potential: a mini review focusing on the pharmacological profile

(2014) Georgios Papazisis et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

(2014) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conception and Evolution of Stereocontrolled Strategies toward Functionalized 8-Aryloctanoic Acids Related to the Total Synthesis of Aliskiren

(2014) Stephen Hanessian et al.   JOURNAL OF ORGANIC CHEMISTRY

Total synthesis of fluoxetine and duloxetine through an in situ imine formation/borylation/transimination and reduction approach

(2014) Adam D. J. Calow et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Highly Efficient Asymmetric Synthesis of Vernakalant

(2014) John Limanto et al.   ORGANIC LETTERS

Development of a Concise, Asymmetric Synthesis of a Smoothened Receptor (SMO) Inhibitor: Enzymatic Transamination of a 4-Piperidinone with Dynamic Kinetic Resolution

(2014) Zhihui Peng et al.   ORGANIC LETTERS

Development of a Biocatalytic Process to Prepare (S)-N-Boc-3-hydroxypiperidine

(2014) Xin Ju et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase

(2014) Naga K. Modukuru et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enzymatic asymmetric synthesis of the silodosin amine intermediate

(2014) Robert C. Simon et al.   TETRAHEDRON-ASYMMETRY

Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations

(2014) Georg Steinkellner et al.   Nature Communications

Synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate in high concentration using a novel halohydrin dehalogenase HHDH-PL from Parvibaculum lavamentivorans DS-1

(2014) Nan-Wei Wan et al.   RSC Advances

Systematic Review: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers for Treating Essential Hypertension

(2013) David B. Matchar et al.   ANNALS OF INTERNAL MEDICINE

Chemical and enzymatic approaches to the synthesis of optically pure ethyl (R)-4-cyano-3-hydroxybutanoate

(2013) Zhong-Yu You et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

On the development of new biocatalytic processes for practical pharmaceutical synthesis

(2013) Gjalt W Huisman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

CC bond formation using ThDP-dependent lyases

(2013) Michael Müller et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemoenzymatic Synthesis of Enantiomerically Puresyn-Configured 1-Aryl-3-methylisochroman Derivatives

(2013) Robert C. Simon et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Scalable biocatalytic synthesis of optically pure ethyl (R)-2-hydroxy-4-phenylbutyrate using a recombinant E. coli with high catalyst yield

(2013) Ye Ni et al.   JOURNAL OF BIOTECHNOLOGY

Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors via Asymmetric Bioreduction of β-Cyanoacrylate Esters Using Ene-Reductases

(2013) Christoph K. Winkler et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Ezetimibe, a Cholesterol Absorption Inhibitor

(2013) Marcin Śnieżek et al.   JOURNAL OF ORGANIC CHEMISTRY

Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products

(2013) Diego Ghislieri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding

(2013) Udaya S. Tantry et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Highly Efficient Synthesis of (R)-3-Quinuclidinol in a Space–Time Yield of 916 g L–1 d–1 Using a New Bacterial Reductase ArQR

(2013) Wen-Xia Zhang et al.   ORGANIC LETTERS

Enzyme-Catalyzed Hydrolysis of Bicycloheptane and Cyclobutene Diesters to Monoesters

(2013) Zhiwei Guo et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine Using an ω-Transaminase Biocatalyst in a Two-Phase System

(2013) Rebecca E. Meadows et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Use of ω-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

(2013) Lianne Frodsham et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

(2013) Cheol K. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts

(2013) Wolfgang Kroutil et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A Highly Productive, Whole-Cell DERA Chemoenzymatic Process for Production of Key Lactonized Side-Chain Intermediates in Statin Synthesis

(2013) Matej Ošlaj et al.   PLoS One

The Value of Neuraminidase Inhibitors for the Prevention and Treatment of Seasonal Influenza: A Systematic Review of Systematic Reviews

(2013) Barbara Michiels et al.   PLoS One

An efficient synthesis for eslicarbazepine acetate, oxcarbazepine, and carbamazepine

(2013) B. Ravinder et al.   TETRAHEDRON LETTERS

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Stereospecific Reduction of Methyl o-Chlorobenzoylformate at 300 g⋅L−1 without Additional Cofactor using a Carbonyl Reductase Mined from Candida glabrata

(2012) Hongmin Ma et al.   ADVANCED SYNTHESIS & CATALYSIS

Ene Reductase-Catalysed Synthesis of (R)-Profen Derivatives

(2012) Jörg Pietruszka et al.   ADVANCED SYNTHESIS & CATALYSIS

Properties and biotechnological applications of halohydrin dehalogenases: current state and future perspectives

(2012) Zhong-Yu You et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent Lipase-Catalyzed Hydrolytic Approaches to Pharmacologically Important β-and γ-Amino Acids

(2012) E. Forro et al.   CURRENT MEDICINAL CHEMISTRY

Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds

(2012) Christoph K. Winkler et al.   JOURNAL OF BIOTECHNOLOGY

CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development

(2012) Carmela Molinaro et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization

(2012) Tao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Enantioselective Synthesis of a Dual Orexin Receptor Antagonist

(2012) Ian K. Mangion et al.   ORGANIC LETTERS

Corey–Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates

(2012) Rajendra D. Mahale et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

(2012) Mélina Girardin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

(2012) K. S. Midelfort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Bioreduction of methyl o-chlorobenzoylformate at 500gL−1 without external cofactors for efficient production of enantiopure clopidogrel intermediate

(2012) Yan Ni et al.   TETRAHEDRON LETTERS

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Catalytic and Structural Features of Flavoprotein Hydroxylases and Epoxidases

(2011) Stefania Montersino et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereoselectivity of Four (R)-Selective Transaminases for the Asymmetric Amination of Ketones

(2011) Francesco G. Mutti et al.   ADVANCED SYNTHESIS & CATALYSIS

Multi-Enzymatic Cascade Reactions: Overview and Perspectives

(2011) Emanuele Ricca et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly efficient synthesis of chiral alcohols with a novel NADH-dependent reductase from Streptomyces coelicolor

(2011) Li-Juan Wang et al.   BIORESOURCE TECHNOLOGY

Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs

(2011) D. Muñoz Solano et al.   BIORESOURCE TECHNOLOGY

Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis

(2011) Ben de Lange et al.   ChemCatChem

Cytochromes P450 as useful biocatalysts: addressing the limitations

(2011) Elaine O'Reilly et al.   CHEMICAL COMMUNICATIONS

C−C Bond-Forming Lyases in Organic Synthesis

(2011) Margarita Brovetto et al.   CHEMICAL REVIEWS

Cytochrome P450: taming a wild type enzyme

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues ofN-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT1AReceptor

(2011) Rana Al Hussainy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Several Generations of Chemoenzymatic Synthesis of Oseltamivir (Tamiflu): Evolution of Strategy, Quest for a Process-Quality Synthesis, and Evaluation of Efficiency Metrics

(2011) Lukas Werner et al.   JOURNAL OF ORGANIC CHEMISTRY

A Formal Synthesis of Ezetimibe via Cycloaddition/Rearrangement Cascade Reaction

(2011) Michał Michalak et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Amination of Chiral Benzylic Ethers Using Chlorosulfonyl Isocyanate: Total Synthesis of (+)-Sertraline

(2011) Sang Hwi Lee et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Catalytic Enantio- and Diastereoselective Aldol Reaction of Thioamides

(2011) Mitsutaka Iwata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

(2011) Neil A. Strotman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

(2011) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

Enantioselective Total Synthesis of the Potent Anti-HIV Nucleoside EFdA

(2011) Masayuki Kageyama et al.   ORGANIC LETTERS

Biotechnological Development of a Practical Synthesis of Ethyl (S)-2-Ethoxy-3-(p-methoxyphenyl)propanoate (EEHP): Over 100-Fold Productivity Increase from Yeast Whole Cells to Recombinant Isolated Enzymes

(2011) Matthias Bechtold et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex

(2011) Ephraim M. Bassan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Commercial Synthesis of (S,S)-Reboxetine Succinate: A Journey To Find the Cheapest Commercial Chemistry for Manufacture

(2011) Stewart T. Hayes et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of an Improved Immobilized CAL-B for the Enzymatic Resolution of a Key Intermediate to Odanacatib

(2011) Matthew D. Truppo et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes

(2011) Concepcion Jimenez-Gonzalez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)

(2011) Pieter D. de Koning et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

LCZ696: a dual-acting sodium supramolecular complex

(2011) Lili Feng et al.   TETRAHEDRON LETTERS

Recent developments in the asymmetric hydrolytic ring opening of epoxides catalysed by microbial epoxide hydrolase

(2011) Neeraj Bala et al.   TETRAHEDRON-ASYMMETRY

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

(2010) Michel Gallant et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases

(2010) Michael Fuchs et al.   CHEMICAL COMMUNICATIONS

A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotère side chain

(2010) Gregory A. Applegate et al.   CHEMICAL COMMUNICATIONS

Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues

(2010) Giovanni Romeo et al.   CHEMICAL REVIEWS

Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists in the Treatment of Migraine

(2010) Paul L. Durham et al.   CNS DRUGS

Recent progress in stereoselective synthesis with aldolases

(2010) Pere Clapés et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Practical chiral alcohol manufacture using ketoreductases

(2010) Gjalt W Huisman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids

(2010) Nicholas J Turner   CURRENT OPINION IN CHEMICAL BIOLOGY

Newer antibacterial drugs for a new century

(2010) Gina Devasahayam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Vernakalant

(2010) Dobromir Dobrev et al.   NATURE REVIEWS DRUG DISCOVERY

Asymmetric Hydrogenation of Bicyclic Ketones Catalyzed by BINAP/IPHAN−Ru(II) Complex

(2010) Noriyoshi Arai et al.   ORGANIC LETTERS

Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid

(2010) Yijun Chen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Resolution of Bis-tetrahydrofuran Alcohol

(2010) Yuri L. Khmelnitsky et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Role of atazanavir in the treatment of HIV infection

(2010) Vincent Soriano   Therapeutics and Clinical Risk Management

Mechanism of the Asymmetric Sulfoxidation in the Esomeprazole Process: Effects of the Imidazole Backbone for the Enantioselection

(2009) Muthu Seenivasaperumal et al.   ADVANCED SYNTHESIS & CATALYSIS

Short Chemoenzymatic Azide-Free Synthesis of Oseltamivir (Tamiflu): Approaching the Potential for Process Efficiency

(2009) Lukas Werner et al.   ADVANCED SYNTHESIS & CATALYSIS

Symmetry-Based Design for the Chemoenzymatic Synthesis of Oseltamivir (Tamiflu) from Ethyl Benzoate

(2009) Bradford Sullivan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Besifloxacin, a Novel Fluoroquinolone, Has Broad-Spectrum In Vitro Activity against Aerobic and Anaerobic Bacteria

(2009) W. Haas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biotechnological production and applications of statins

(2009) Javier Barrios-González et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Microbial cells as catalysts for stereoselective red–ox reactions

(2009) J.D. Carballeira et al.   BIOTECHNOLOGY ADVANCES

Transaminase-catalyzed asymmetric synthesis of l-2-aminobutyric acid from achiral reactants

(2009) Jong-Shik Shin et al.   BIOTECHNOLOGY LETTERS

Biocatalytic Routes to Optically Active Amines

(2009) Matthias Höhne et al.   ChemCatChem

Biocatalytic carboxylation

(2009) Silvia M. Glueck et al.   CHEMICAL SOCIETY REVIEWS

Boceprevir, an NS3 Protease Inhibitor of HCV

(2009) Kenneth Berman et al.   Clinics in Liver Disease

Biocatalysis in development of green pharmaceutical processes

(2009) Junhua Tao et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Hydroxylation of l-proline to cis-3-hydroxy-l-proline by recombinant Escherichia coli expressing a synthetic l-proline-3-hydroxylase gene

(2009) Robert M. Johnston et al.   ENZYME AND MICROBIAL TECHNOLOGY

A green-by-design biocatalytic process for atorvastatin intermediate

(2009) Steven K. Ma et al.   GREEN CHEMISTRY

Synthesis of 4-phenylpyrrolidin-2-one via dynamic kinetic resolution catalyzed by ω-transaminases

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Ru-catalyzed enantioselective preparation of methyl (R)-o-chloromandelate and its application in the synthesis of (S)-Clopidogrel

(2009) Lu Yin et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Highly Efficient Asymmetric Synthesis of Sitagliptin

(2009) Karl B. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

Enzymatic Desymmetrization of Dimethyl Cylcohex-4-ene-cis-1,2-dicarboxylate to (1S,2R)-2-(Methoxycarbonyl)cyclohex-4-ene-1-carboxylic Acid

(2009) Animesh Goswami et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An Improved and Scalable Process for the Synthesis of Ezetimibe: An Antihypercholesterolemia Drug†

(2009) C. H. V. A. Sasikala et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Biocatalytic Processes

(2009) Nagaraj N. Rao et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Routes for the Synthesis of (2S)-2-Methyltetrahydropyran-4-one from Simple Optically Pure Building Blocks

(2009) Kevin R. Anderson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol

(2009) Jack Liang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Biocatalytic Process as an Alternative to the (−)-DIP-Cl-Mediated Asymmetric Reduction of a Key Intermediate of Montelukast

(2009) Jack Liang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations

(2008) Paul F. Mugford et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding enzyme immobilisation

(2008) Ulf Hanefeld et al.   CHEMICAL SOCIETY REVIEWS

Heme-iron oxygenases: powerful industrial biocatalysts?

(2008) Mattijs K Julsing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Esomeprazole

(2008) Kate McKeage et al.   DRUGS

Enzymatic Method for the Synthesis of Blockbuster Drug Intermediates - Synthesis of Five-Membered Cyclic γ-Amino Acid and γ-Lactam Enantiomers

(2008) Enikő Forró et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New, Efficient Synthesis of Oseltamivir Phosphate (Tamiflu) via Enzymatic Desymmetrization of ameso-1,3-Cyclohexanedicarboxylic Acid Diester

(2008) Ulrich Zutter et al.   JOURNAL OF ORGANIC CHEMISTRY

Orchestration of Concurrent Oxidation and Reduction Cycles for Stereoinversion and Deracemisation ofsec-Alcohols

(2008) Constance V. Voss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparative Asymmetric Synthesis of 4,4-Dimethoxytetrahydro-2H-pyran-3-ol with a Ketone Reductase and in Situ Cofactor Recycling using Glucose Dehydrogenase

(2008) Birgit Kosjek et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enzymatic Preparation of ad-Amino Acid from a Racemic Amino Acid or Keto Acid

(2008) Ronald L. Hanson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Chemoenzymatic Manufacturing Process for Pregabalin

(2008) Carlos A. Martinez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Optimisation of stabilised Carboxylesterase NP for enantioselective hydrolysis of naproxen methyl ester

(2008) Lucia Steenkamp et al.   PROCESS BIOCHEMISTRY

Deracemization of Secondary Alcohols through a Concurrent Tandem Biocatalytic Oxidation and Reduction

(2007) Constance V. Voss et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation

(2007) Shan Zhen He et al.   CHINESE CHEMICAL LETTERS

Synthesis of chiral pharmaceutical intermediates by biocatalysis

(2007) Ramesh N. Patel   COORDINATION CHEMISTRY REVIEWS

Recent applications of biocatalysis in developing green chemistry for chemical synthesis at the industrial scale

(2007) Ningqing Ran et al.   GREEN CHEMISTRY

Alternative pig liver esterase (APLE) – Cloning, identification and functional expression in Pichia pastoris of a versatile new biocatalyst

(2007) Manuela Hermann et al.   JOURNAL OF BIOTECHNOLOGY

Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048)

(2007) Amin A. Nomeir et al.   JOURNAL OF MASS SPECTROMETRY

The active site of hydroxynitrile lyase from Prunus amygdalus: Modeling studies provide new insights into the mechanism of cyanogenesis

(2002) Ingrid Dreveny et al.   PROTEIN SCIENCE