Multi-Enzymatic Cascade Reactions: Overview and Perspectives

Deracemisation of Mandelic Acid to Optically Pure Non-Natural L-Phenylglycine via a Redox-Neutral Biocatalytic Cascade

(2010) Verena Resch et al.   ADVANCED SYNTHESIS & CATALYSIS

Combining Designer Cells and Click Chemistry for a One-Pot Four-Step Preparation of Enantiopure β-Hydroxytriazoles

(2010) Wiktor Szymanski et al.   ADVANCED SYNTHESIS & CATALYSIS

Efficient biosynthesis of uridine diphosphate glucose from maltodextrin by multiple enzymes immobilized on magnetic nanoparticles

(2010) Qing Dong et al.   CARBOHYDRATE RESEARCH

Oxidoreductases Working Together: Concurrent Obtaining of Valuable Derivatives by Employing the PIKAT Method

(2010) Fabricio R. Bisogno et al.   ChemCatChem

Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases

(2010) Michael Fuchs et al.   CHEMICAL COMMUNICATIONS

Highly efficient chemoenzymatic synthesis of β1–4-linked galactosides with promiscuous bacterial β1–4-galactosyltransferases

(2010) Kam Lau et al.   CHEMICAL COMMUNICATIONS

A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

(2010) Jennifer Hopwood et al.   CHEMICAL COMMUNICATIONS

Preparation and Characterization of a Bifunctional Aldolase/Kinase Enzyme: A More Efficient Biocatalyst for CC Bond Formation

(2010) Laura Iturrate et al.   CHEMISTRY-A EUROPEAN JOURNAL

Deracemisation methods

(2010) Nicholas J Turner   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent biocatalytic oxidation–reduction cascades

(2010) Joerg H Schrittwieser et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Asymmetric biocatalysis with microbial enzymes and cells

(2010) Roland Wohlgemuth   CURRENT OPINION IN MICROBIOLOGY

Application of continuous stirred membrane reactor to 3-cyanopyridine bioconversion using the nitrile hydratase–amidase cascade system of Microbacterium imperiale CBS 498-74

(2010) L. Cantarella et al.   ENZYME AND MICROBIAL TECHNOLOGY

Deracemization of aryl secondary alcohols via enantioselective oxidation and stereoselective reduction with tandem whole-cell biocatalysts

(2010) Yun-Long Li et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

ω-Transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis

(2010) Leandro H. Andrade et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Micro-scale process development of transaminase catalysed reactions

(2010) Matthew D. Truppo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biocatalysed concurrent production of enantioenriched compounds through parallel interconnected kinetic asymmetric transformations

(2010) Ana Rioz-Martínez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multienzyme-Catalyzed Processes: Next-Generation Biocatalysis

(2010) Paloma A. Santacoloma et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Activated α,β-Unsaturated Aldehydes as Substrate of Dihydroxyacetone Phosphate (DHAP)-Dependent Aldolases in the Context of a Multienzyme System

(2009) Israel Sánchez-Moreno et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Aliphatic (S)-α-Hydroxycarboxylic Amides using a One-Pot Bienzymatic Cascade of Immobilised Oxynitrilase and Nitrile Hydratase

(2009) Sander van Pelt et al.   ADVANCED SYNTHESIS & CATALYSIS

One-Pot Multienzymatic Synthesis of 12-Ketoursodeoxycholic Acid: Subtle Cofactor Specificities Rule the Reaction Equilibria of Five Biocatalysts Working in a Row

(2009) Daniela Monti et al.   ADVANCED SYNTHESIS & CATALYSIS

Enzymatic Synthesis of Amoxicillin via a One-pot Enzymatic Hydrolysis and Condensation Cascade Process in the Presence of Organic Co-solvents

(2009) Qi Wu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Optimization of inulin hydrolysis by inulinase accounting for enzyme time- and temperature-dependent deactivation

(2009) Emanuele Ricca et al.   BIOCHEMICAL ENGINEERING JOURNAL

Biocatalytic cascade oxidation using laccase for pyranose 2-oxidase regeneration

(2009) Wouter Van Hecke et al.   BIORESOURCE TECHNOLOGY

Production of N-acetyl-D-neuraminic acid using two sequential enzymes overexpressed as double-tagged fusion proteins

(2009) Tzu-Hsien Wang et al.   BMC BIOTECHNOLOGY

Improvement of an Acid Phosphatase/DHAP-Dependent Aldolase Cascade Reaction by Using Directed Evolution

(2009) Teunie van Herk et al.   CHEMBIOCHEM

Biocatalytic Routes to Optically Active Amines

(2009) Matthias Höhne et al.   ChemCatChem

Synthesis of Optically Active Amines Employing Recombinant ω-Transaminases inE. coliCells

(2009) Dominik Koszelewski et al.   ChemCatChem

Substrate channelling in an engineered bifunctional aldolase/kinase enzyme confers catalytic advantage for C–C bond formation

(2009) Laura Iturrate et al.   CHEMICAL COMMUNICATIONS

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

(2009) Matthew D. Truppo et al.   CHEMICAL COMMUNICATIONS

Process integration for the conversion of glucose to 2,5-furandicarboxylic acid

(2009) A. Boisen et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Multi-enzymatic synthesis

(2009) Fernando Lopez-Gallego et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Deracemisation of α-Chiral Primary Amines by a One-Pot, Two-Step Cascade Reaction Catalysed by ω-Transaminases

(2009) Dominik Koszelewski et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Biocatalytic Cascade for the Synthesis of Enantiopure β-Azidoalcohols and β-Hydroxynitriles

(2009) Joerg H. Schrittwieser et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A green-by-design biocatalytic process for atorvastatin intermediate

(2009) Steven K. Ma et al.   GREEN CHEMISTRY

Synthesis of 4-phenylpyrrolidin-2-one via dynamic kinetic resolution catalyzed by ω-transaminases

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Immobilization of ω-transaminases by encapsulation in a sol–gel/celite matrix

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Asymmetric Synthesis of Both Antipodes of β-Hydroxy Nitriles and β-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis

(2009) Haribabu Ankati et al.   JOURNAL OF ORGANIC CHEMISTRY

Tandem Concurrent Processes: One-Pot Single-Catalyst Biohydrogen Transfer for the Simultaneous Preparation of Enantiopure Secondary Alcohols

(2009) Fabricio R. Bisogno et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesizing our future

(2009) Ryoji Noyori   Nature Chemistry

Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids

(2009) Hongzhi Cao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

Efficient Production of Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases

(2009) Matthew D. Truppo et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fructose production by chicory inulin enzymatic hydrolysis: A kinetic study and reaction mechanism

(2009) Emanuele Ricca et al.   PROCESS BIOCHEMISTRY

Lipase-catalysed kinetic resolutions of secondary alcohols in pressurised liquid hydrofluorocarbons

(2009) Anthony J. Ball et al.   TETRAHEDRON LETTERS

Shifting the equilibrium of a biocatalytic cascade synthesis to enantiopure epoxides using anion exchangers

(2009) Joerg H. Schrittwieser et al.   TETRAHEDRON-ASYMMETRY

Recent progress in biocatalysis for asymmetric oxidation and reduction

(2009) Tomoko Matsuda et al.   TETRAHEDRON-ASYMMETRY

Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases

(2008) Dominik Koszelewski et al.   ADVANCED SYNTHESIS & CATALYSIS

Formal Asymmetric Biocatalytic Reductive Amination

(2008) Dominik Koszelewski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoenzymatic synthesis of the chiral side-chain of statins: application of an alcohol dehydrogenase catalysed ketone reduction on a large scale

(2008) Michael Wolberg et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Characterization of enzymatic D-xylulose 5-phosphate synthesis

(2008) Jobin Shaeri et al.   BIOTECHNOLOGY AND BIOENGINEERING

Kinetic modeling of a bi-enzymatic system for efficient conversion of lactose to lactobionic acid

(2008) Wouter Van Hecke et al.   BIOTECHNOLOGY AND BIOENGINEERING

Efficient Asymmetric Synthesis of Chiral Amines by Combining Transaminase and Pyruvate Decarboxylase

(2008) Matthias Höhne et al.   CHEMBIOCHEM

E factors, green chemistry and catalysis: an odyssey

(2008) Roger A. Sheldon   CHEMICAL COMMUNICATIONS

Orchestration of Concurrent Oxidation and Reduction Cycles for Stereoinversion and Deracemisation ofsec-Alcohols

(2008) Constance V. Voss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid screening and scale-up of transaminase catalysed reactions

(2008) Matthew D. Truppo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

New opportunities for biocatalysis: making pharmaceutical processes greener

(2008) John M. Woodley   TRENDS IN BIOTECHNOLOGY

Deracemization of Secondary Alcohols through a Concurrent Tandem Biocatalytic Oxidation and Reduction

(2007) Constance V. Voss et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Techno-Economic Evaluation of Producing Ethanol from Softwood: Comparison of SSF and SHF and Identification of Bottlenecks

(2003) Anders Wingren et al.   BIOTECHNOLOGY PROGRESS