The Industrial Age of Biocatalytic Transamination

Selective Access to All Four Diastereomers of a 1,3-Amino Alcohol by Combination of a Keto Reductase- and an Amine Transaminase-Catalysed Reaction

(2015) Hannes Kohls et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalytic Asymmetric Synthesis of Optically Pure Aromatic Propargylic Amines Employing ω-Transaminases

(2015) Nina G. Schmidt et al.   ADVANCED SYNTHESIS & CATALYSIS

A subfamily of PLP-dependent enzymes specialized in handling terminal amines

(2015) Davide Schiroli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

(2015) Fabian Steffen-Munsberg et al.   BIOTECHNOLOGY ADVANCES

Two Subtle Amino Acid Changes in a Transaminase Substantially Enhance or Invert Enantiopreference in Cascade Syntheses

(2015) Lilly Skalden et al.   CHEMBIOCHEM

Engineering the Active Site of the Amine Transaminase fromVibrio fluvialisfor the Asymmetric Synthesis of Aryl-Alkyl Amines and Amino Alcohols

(2015) Alberto Nobili et al.   ChemCatChem

The coupling of ω-transaminase and Oppenauer oxidation reactions via intra-membrane multicomponent diffusion – A process model for the synthesis of chiral amines

(2015) T. Esparza-Isunza et al.   CHEMICAL ENGINEERING JOURNAL

A system for ω-transaminase mediated (R)-amination using l-alanine as an amine donor

(2015) N. Richter et al.   GREEN CHEMISTRY

A quantum chemical study of the ω-transaminase reaction mechanism

(2015) Karim Engelmark Cassimjee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Biocatalytic Amination of Ketones at the Expense of NH3 and Molecular Hydrogen

(2015) Anja K. Holzer et al.   ORGANIC LETTERS

Cutting Short the Asymmetric Synthesis of the Ramatroban Precursor by Employing ω-Transaminases

(2014) Eduardo Busto et al.   ADVANCED SYNTHESIS & CATALYSIS

Dynamic Kinetic Resolution of 2-Phenylpropanal Derivatives to Yield β-Chiral Primary AminesviaBioamination

(2014) Christine S. Fuchs et al.   ADVANCED SYNTHESIS & CATALYSIS

Structural Determinants for the Non-Canonical Substrate Specificity of the ω-Transaminase fromParacoccus denitrificans

(2014) Eul-Soo Park et al.   ADVANCED SYNTHESIS & CATALYSIS

Glycine Oxidase Based High-Throughput Solid-Phase Assay for Substrate Profiling and Directed Evolution of (R)- and (S)-Selective Amine Transaminases

(2014) Martin S. Weiß et al.   ANALYTICAL CHEMISTRY

New Generation of Biocatalysts for Organic Synthesis

(2014) Bettina M. Nestl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening

(2014) Anthony P. Green et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid

(2014) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea

(2014) Qingyang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of (R)-selective amine transaminases identified by in silico motif sequence blast

(2014) Jinju Jiang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Redox self-sufficient whole cell biotransformation for amination of alcohols

(2014) Stephanie Klatte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Monoamine Oxidase-ω-Transaminase Cascade for the Deracemisation and Dealkylation of Amines

(2014) Elaine O'Reilly et al.   ChemCatChem

Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

(2014) Nina Richter et al.   CHEMICAL COMMUNICATIONS

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

(2014) Hannes Kohls et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Combining the ‘two worlds’ of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media

(2014) Harald Gröger et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca

(2014) Christopher Sayer et al.   FEBS Journal

Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo)ephedrine isomers

(2014) Torsten Sehl et al.   GREEN CHEMISTRY

A Highly Efficient Asymmetric Synthesis of Vernakalant

(2014) John Limanto et al.   ORGANIC LETTERS

Continuous Flow Synthesis of Chiral Amines in Organic Solvents: Immobilization of E. coli Cells Containing Both ω-Transaminase and PLP

(2014) Leandro H. Andrade et al.   ORGANIC LETTERS

Development of a Concise, Asymmetric Synthesis of a Smoothened Receptor (SMO) Inhibitor: Enzymatic Transamination of a 4-Piperidinone with Dynamic Kinetic Resolution

(2014) Zhihui Peng et al.   ORGANIC LETTERS

Crystal Structure of an (R)-Selective ω-Transaminase from Aspergillus terreus

(2014) Andrzej Łyskowski et al.   PLoS One

Enzymatic asymmetric synthesis of the silodosin amine intermediate

(2014) Robert C. Simon et al.   TETRAHEDRON-ASYMMETRY

Crystallographic characterization of the (R)-selective amine transaminase fromAspergillus fumigatus

(2014) Maren Thomsen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Asymmetric Synthesis of 3-Substituted Cyclohexylamine Derivatives from Prochiral DiketonesviaThree Biocatalytic Steps

(2013) Elina Siirola et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Terminal Alkylamino-FunctionalizationviaMultistep Biocatalysis in One Recombinant Whole-Cell Catalyst

(2013) Manfred Schrewe et al.   ADVANCED SYNTHESIS & CATALYSIS

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent trends and novel concepts in cofactor-dependent biotransformations

(2013) Selin Kara et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Active site model of (R)-selective ω-transaminase and its application to the production of d-amino acids

(2013) Eul-Soo Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Coupled Enzymatic Alcohol-to-Amine Conversion of Isosorbide using Engineered Transaminases and Dehydrogenases

(2013) Alexandra Lerchner et al.   ChemCatChem

Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

(2013) Aníbal Cuetos et al.   CHEMICAL COMMUNICATIONS

One-pot one-step deracemization of amines using ω-transaminases

(2013) Giyoung Shin et al.   CHEMICAL COMMUNICATIONS

Artificial Multi-Enzyme Networks for the Asymmetric Amination ofsec-Alcohols

(2013) Katharina Tauber et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemoenzymatic Synthesis of All Four Diastereomers of 2,6-Disubstituted Piperidines through Stereoselective Monoamination of 1,5-Diketones

(2013) Robert C. Simon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzyme catalysed tandem reactions

(2013) Isabel Oroz-Guinea et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

On the development of new biocatalytic processes for practical pharmaceutical synthesis

(2013) Gjalt W Huisman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine Using an ω-Transaminase Biocatalyst in a Two-Phase System

(2013) Rebecca E. Meadows et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Use of ω-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

(2013) Lianne Frodsham et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

(2013) Cheol K. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts

(2013) Wolfgang Kroutil et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Transaminases Applied to the Synthesis of High Added-Value Enantiopure Amines

(2013) Caroline E. Paul et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Crystal structure of the ω-aminotransferase fromParacoccus denitrificansand its phylogenetic relationship with other class III amino- transferases that have biotechnological potential

(2013) Christian Rausch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Asymmetric Amination of Tetralone and Chromanone Derivatives Employing ω-Transaminases

(2013) Desiree Pressnitz et al.   ACS Catalysis

Recent Developments of Cascade Reactions Involving ω-Transaminases

(2013) Robert C. Simon et al.   ACS Catalysis

Asymmetric Bio-amination of Ketones in Organic Solvents

(2012) Francesco G. Mutti et al.   ADVANCED SYNTHESIS & CATALYSIS

Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols

(2012) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Stereoselective Monoamination of Diketones without Protecting Groups

(2012) Robert C. Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Features and technical applications of ω-transaminases

(2012) M. Shaheer Malik et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

(2012) Matthew D. Truppo et al.   ChemCatChem

Connecting Unexplored Protein Crystal Structures to Enzymatic Function

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP

(2012) Maria S. Humble et al.   FEBS Journal

Asymmetric Chemoenzymatic Synthesis of Ramatroban Using Lipases and Oxidoreductases

(2012) Eduardo Busto et al.   JOURNAL OF ORGANIC CHEMISTRY

CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development

(2012) Carmela Molinaro et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective synthesis of vicinal amino alcohols

(2012) Oskari K. Karjalainen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Synthesis of a Dual Orexin Receptor Antagonist

(2012) Ian K. Mangion et al.   ORGANIC LETTERS

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

(2012) Mélina Girardin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

(2012) K. S. Midelfort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Improved chemoenzymatic asymmetric synthesis of (S)-Rivastigmine

(2012) Michael Fuchs et al.   TETRAHEDRON

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

(2012) Sam Mathew et al.   ACS Catalysis

Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

(2012) Michael Fuchs et al.   RSC Advances

Transaminases for the synthesis of enantiopure beta-amino acids

(2012) Jens Rudat et al.   AMB Express

Multi-Enzymatic Cascade Reactions: Overview and Perspectives

(2011) Emanuele Ricca et al.   ADVANCED SYNTHESIS & CATALYSIS

Enzymatic Asymmetric Synthesis of Enantiomerically Pure Aliphatic, Aromatic and Arylaliphatic Amines with (R)-Selective Amine Transaminases

(2011) Sebastian Schätzle et al.   ADVANCED SYNTHESIS & CATALYSIS

Molecular determinants for substrate selectivity of ω-transaminases

(2011) Eul-Soo Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Process considerations for the asymmetric synthesis of chiral amines using transaminases

(2011) Pär Tufvesson et al.   BIOTECHNOLOGY AND BIOENGINEERING

Role of the Pyridine Nitrogen in Pyridoxal 5′-Phosphate Catalysis: Activity of Three Classes of PLP Enzymes Reconstituted with Deazapyridoxal 5′-Phosphate

(2011) Wait R. Griswold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active Site Quantification of an ω-Transaminase by Performing a Half Transamination Reaction

(2011) Karim Engelmark Cassimjee et al.   ACS Catalysis

An Efficient and General Synthesis of Primary Amines by Ruthenium-Catalyzed Amination of Secondary Alcohols with Ammonia

(2010) Sebastian Imm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

(2010) Michel Gallant et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases

(2010) Michael Fuchs et al.   CHEMICAL COMMUNICATIONS

Enzymatic Racemization of Amines Catalyzed by Enantiocomplementary ω-Transaminases

(2010) Dominik Koszelewski et al.   CHEMISTRY-A EUROPEAN JOURNAL

New Trends in the Recycling of NAD(P)H for the Design of Sustainable Asymmetric Reductions Catalyzed by Dehydrogenases

(2010) Angel Berenguer-Murcia et al.   CURRENT ORGANIC CHEMISTRY

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

ω-Transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis

(2010) Leandro H. Andrade et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Rapid and Sensitive Kinetic Assay for Characterization of ω-Transaminases

(2009) Sebastian Schätzle et al.   ANALYTICAL CHEMISTRY

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

(2009) Matthew D. Truppo et al.   CHEMICAL COMMUNICATIONS

Deracemisation of α-Chiral Primary Amines by a One-Pot, Two-Step Cascade Reaction Catalysed by ω-Transaminases

(2009) Dominik Koszelewski et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 4-phenylpyrrolidin-2-one via dynamic kinetic resolution catalyzed by ω-transaminases

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Immobilization of ω-transaminases by encapsulation in a sol–gel/celite matrix

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/ω-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol

(2009) Mark E. B. Smith et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Efficient Production of Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases

(2009) Matthew D. Truppo et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases

(2008) Dominik Koszelewski et al.   ADVANCED SYNTHESIS & CATALYSIS

Selective Synthesis of Primary Amines Directly from Alcohols and Ammonia

(2008) Chidambaram Gunanathan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formal Asymmetric Biocatalytic Reductive Amination

(2008) Dominik Koszelewski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Asymmetric Synthesis of Chiral Amines by Combining Transaminase and Pyruvate Decarboxylase

(2008) Matthias Höhne et al.   CHEMBIOCHEM

Rapid screening and scale-up of transaminase catalysed reactions

(2008) Matthew D. Truppo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY