Biocatalytic Imine Reduction and Reductive Amination of Ketones

Synthesis ofD- andL-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process

(2015) Fabio Parmeggiani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

(2015) Shahed Hussain et al.   ChemCatChem

Engineering of Amine Dehydrogenase for Asymmetric Reductive Amination of Ketone by Evolving Rhodococcus Phenylalanine Dehydrogenase

(2015) Li Juan Ye et al.   ACS Catalysis

Deracemization By Simultaneous Bio-oxidative Kinetic Resolution and Stereoinversion

(2014) Joerg H. Schrittwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spectrophotometric assay of d-isoleucine using an artificially created d-amino acid dehydrogenase

(2014) Hironaga Akita et al.   BIOTECHNOLOGY LETTERS

Expanding the Chemical Diversity in Artificial Imine Reductases Based on the Biotin-Streptavidin Technology

(2014) Tommaso Quinto et al.   ChemCatChem

Development of an R -Selective Amine Oxidase with Broad Substrate Specificity and High Enantioselectivity

(2014) Rachel S. Heath et al.   ChemCatChem

Biocatalysis as a Strategic Green Technology for the Chemical Industry

(2014) Andy Wells et al.   ChemCatChem

Direct Reductive Amination of Ketones: Structure and Activity ofS-Selective Imine Reductases fromStreptomyces

(2014) Tobias Huber et al.   ChemCatChem

An Artificial Imine Reductase based on the Ribonuclease S Scaffold

(2014) Maika Genz et al.   ChemCatChem

A novel chimeric amine dehydrogenase shows altered substrate specificity compared to its parent enzymes

(2014) Bettina R. Bommarius et al.   CHEMICAL COMMUNICATIONS

Enantioselective imine hydrogenation with iridium-catalysts: Reactions, mechanisms and stereocontrol

(2014) Kathrin Helen Hopmann et al.   COORDINATION CHEMISTRY REVIEWS

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

(2014) Hannes Kohls et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Artificial metalloenzymes for enantioselective catalysis

(2014) Jeffrey Bos et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Characterization of three novel enzymes with imine reductase activity

(2014) M. Gand et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Enantioselective imine reduction catalyzed by imine reductases and artificial metalloenzymes

(2014) Daniela Gamenara et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biphasic Reaction System Allows for Conversion of Hydrophobic Substrates by Amine Dehydrogenases

(2014) Samantha K. Au et al.   ACS Catalysis

Organocatalytic strategies for enantioselective metal-free reductions

(2014) Sergio Rossi et al.   Catalysis Science & Technology

The Evolution of an Amine Dehydrogenase Biocatalyst for the Asymmetric Production of Chiral Amines

(2013) Michael J. Abrahamson et al.   ADVANCED SYNTHESIS & CATALYSIS

Lysine metabolism in mammalian brain: an update on the importance of recent discoveries

(2013) André Hallen et al.   AMINO ACIDS

Efficient synthesis of d-branched-chain amino acids and their labeled compounds with stable isotopes using d-amino acid dehydrogenase

(2013) Hironaga Akita et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent trends and novel concepts in cofactor-dependent biotransformations

(2013) Selin Kara et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Opine Dehydrogenases in Marine Invertebrates

(2013) Matija Harcet et al.   BIOCHEMICAL GENETICS

Tetrahydrobiopterin: biochemistry and pathophysiology

(2013) Ernst R. Werner et al.   BIOCHEMICAL JOURNAL

Structure and Activity of NADPH-Dependent Reductase Q1EQE0 fromStreptomyces kanamyceticus, which Catalyses theR-Selective Reduction of an Imine Substrate

(2013) María Rodríguez-Mata et al.   CHEMBIOCHEM

Enantioselective Synthesis of N-Substituted Aspartic Acids Using an Engineered Variant of Methylaspartate Ammonia Lyase

(2013) Vinod Puthan Veetil et al.   ChemCatChem

Asymmetric Reduction of Cyclic Imines Catalyzed by a Whole-Cell Biocatalyst Containing an (S)-Imine Reductase

(2013) Friedemann Leipold et al.   ChemCatChem

Enantioselective Synthesis of Alcohols and Amines by Iridium-Catalyzed Hydrogenation, Transfer Hydrogenation, and Related Processes

(2013) Agnieszka Bartoszewicz et al.   CHEMISTRY-A EUROPEAN JOURNAL

On the development of new biocatalytic processes for practical pharmaceutical synthesis

(2013) Gjalt W Huisman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology

(2013) Jeremy M. Zimbron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products

(2013) Diego Ghislieri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Divergent evolution of protein conformational dynamics in dihydrofolate reductase

(2013) Gira Bhabha et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enzymatic Preparation of an R-Amino Acid Intermediate for a γ-Secretase Inhibitor

(2013) Ronald L. Hanson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Stereoselective bioreduction of β-carboline imines through cell-free extracts from earthworms (Eisenia foetida)

(2013) Yaneris Mirabal-Gallardo et al.   TETRAHEDRON-ASYMMETRY

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Monoamine Oxidase (MAO-N) Catalyzed Deracemization of Tetrahydro-β-carbolines: Substrate Dependent Switch in Enantioselectivity

(2013) Diego Ghislieri et al.   ACS Catalysis

Genetic Optimization of the Catalytic Efficiency of Artificial Imine Reductases Based on Biotin–Streptavidin Technology

(2013) Fabian Schwizer et al.   ACS Catalysis

Recent Developments of Cascade Reactions Involving ω-Transaminases

(2013) Robert C. Simon et al.   ACS Catalysis

Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis

(2013) Jared C. Lewis   ACS Catalysis

Enantiomeric Natural Products: Occurrence and Biogenesis

(2012) Jennifer M. Finefield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

(2012) Michael J. Abrahamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A NADPH-dependent (S)-imine reductase (SIR) from Streptomyces sp. GF3546 for asymmetric synthesis of optically active amines: purification, characterization, gene cloning, and expression

(2012) Koichi Mitsukura et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Two Structures of a Thiazolinyl Imine Reductase from Yersinia enterocolitica Provide Insight into Catalysis and Binding to the Nonribosomal Peptide Synthetase Module of HMWP1

(2012) Kathleen M. Meneely et al.   BIOCHEMISTRY

Creation of a thermostable NADP+-dependent d-amino acid dehydrogenase from Ureibacillus thermosphaericus strain A1 meso-diaminopimelate dehydrogenase by site-directed mutagenesis

(2012) Hironaga Akita et al.   BIOTECHNOLOGY LETTERS

Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis

(2012) Christopher M. Clouthier et al.   CHEMICAL SOCIETY REVIEWS

Homogeneous palladium-catalyzed asymmetric hydrogenation

(2012) Qing-An Chen et al.   CHEMICAL SOCIETY REVIEWS

Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities

(2012) Arlene A Sy-Cordero et al.   JOURNAL OF ANTIBIOTICS

A psychrophilic leucine dehydrogenase from Sporosarcina psychrophila: Purification, characterization, gene sequencing and crystal structure analysis

(2012) Ying Zhao et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

(2012) V. Köhler et al.   Nature Chemistry

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

(2012) Hans Raj et al.   Nature Chemistry

“Frustrated Lewis pair” hydrogenations

(2012) Douglas W. Stephan   ORGANIC & BIOMOLECULAR CHEMISTRY

F420-dependent enzymes – potential for applications in biotechnology

(2012) Matthew Taylor et al.   TRENDS IN BIOTECHNOLOGY

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

(2012) Sam Mathew et al.   ACS Catalysis

In vitro conversion of chanoclavine-I aldehyde to the stereoisomers festuclavine and pyroclavine controlled by the second reduction step

(2012) Marco Matuschek et al.   RSC Advances

Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines

(2011) Marc Dürrenberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Parallel Pathways in the Kinetic Sequence of the Dihydrofolate Reductase fromMycobacterium tuberculosis

(2011) Clarissa M. Czekster et al.   BIOCHEMISTRY

Purification and Characterization of a Novel (R)-Imine Reductase fromStreptomycessp. GF3587

(2011) Koichi MITSUKURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Cyclosporin A — A review on fermentative production, downstream processing and pharmacological applications

(2011) Shrikant A. Survase et al.   BIOTECHNOLOGY ADVANCES

Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis

(2011) Ben de Lange et al.   ChemCatChem

Merging the best of two worlds: artificial metalloenzymes for enantioselective catalysis

(2011) Mark R. Ringenberg et al.   CHEMICAL COMMUNICATIONS

Hydrolases in the Stereoselective Synthesis ofN-Heterocyclic Amines and Amino Acid Derivatives

(2011) Eduardo Busto et al.   CHEMICAL REVIEWS

Insights into the Biosynthesis of Hormaomycin, An Exceptionally Complex Bacterial Signaling Metabolite

(2011) Ivonne Höfer et al.   CHEMISTRY & BIOLOGY

Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones

(2011) André Hallen et al.   JOURNAL OF NEUROCHEMISTRY

Biocatalysis: Synthesis of Key Intermediates for Development of Pharmaceuticals

(2011) Ramesh N. Patel   ACS Catalysis

Organocatalytic asymmetric transfer hydrogenation of imines

(2011) Johannes G. de Vries et al.   Catalysis Science & Technology

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

(2010) Thomas C. Nugent et al.   ADVANCED SYNTHESIS & CATALYSIS

Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids

(2010) Nicholas J Turner   CURRENT OPINION IN CHEMICAL BIOLOGY

New Trends in the Recycling of NAD(P)H for the Design of Sustainable Asymmetric Reductions Catalyzed by Dehydrogenases

(2010) Angel Berenguer-Murcia et al.   CURRENT ORGANIC CHEMISTRY

New insights into an old story: Agrobacterium-induced tumour formation in plants by plant transformation

(2010) Andrea Pitzschke et al.   EMBO JOURNAL

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

(2010) Barbara Gerratana   MEDICINAL RESEARCH REVIEWS

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Asymmetric synthesis of chiral cyclic amine from cyclic imine by bacterial whole-cell catalyst of enantioselective imine reductase

(2010) Koichi Mitsukura et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3

(2010) Christiane Wallwey et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Insights into the Mechanism of Ligand Binding to Octopine Dehydrogenase from Pecten maximus by NMR and Crystallography

(2010) Sander H. J. Smits et al.   PLoS One

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Bioreduction of β-carboline imines to amines employing Saccharomyces bayanus

(2010) Marlene Espinoza-Moraga et al.   TETRAHEDRON-ASYMMETRY

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog

(2009) W. Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic

(2009) W. Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biocatalytic Routes to Optically Active Amines

(2009) Matthias Höhne et al.   ChemCatChem

Biocatalysis in development of green pharmaceutical processes

(2009) Junhua Tao et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Substituent Effects on the Thermodynamic Stability of Imines Formed from Glycine and Aromatic Aldehydes: Implications for the Catalytic Activity of Pyridoxal-5′-phosphate

(2009) Juan Crugeiras et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Potencies and Relative Toxicities of Coniine Enantiomers

(2008) Stephen T. Lee et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Biocatalytic Enantioselective Synthesis ofN-Substituted Aspartic Acids by Aspartate Ammonia Lyase

(2008) Barbara Weiner et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Structural Basis for Substrate Selectivity and Stereoselectivity in Octopine Dehydrogenase from Pecten maximus

(2008) Sander H.J. Smits et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribosomal Synthesis ofN-Methyl Peptides

(2008) Alexander O. Subtelny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Purification, characterization and crystallization of pyrroline-5-carboxylate reductase from the hyperthermophilic archeon Sulfolobus Solfataricus

(2008) Zhaohui Meng et al.   PROTEIN EXPRESSION AND PURIFICATION

Asymmetric reduction of aryl imines using Candida parapsilosis ATCC 7330

(2008) T. Vaijayanthi et al.   TETRAHEDRON-ASYMMETRY