Single mutations of ketoreductase ChKRED20 enhance the bioreductive production of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol

Efficient bioreductive production of (S)-N-Boc-3-hydroxypiperidine using ketoreductase ChKRED03

(2016) Guang-Peng Xu et al.   PROCESS BIOCHEMISTRY

Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase

(2016) Zhoutong Sun et al.   ACS Catalysis

Rapid asymmetric reduction of ethyl 4-chloro-3-oxobutanoate using a thermostabilized mutant of ketoreductase ChKRED20

(2015) Feng-Jiao Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioreductive production of enantiopure (S)-duloxetine intermediates catalyzed with ketoreductase ChKRED15

(2015) Zhi-Qiang Ren et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Synthesis of enantiopure glycidol derivatives via a one-pot two-step enzymatic cascade

(2015) Yu-Chang Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Controlling Substrate Specificity and Stereospecificity of Alcohol Dehydrogenases

(2015) Christopher M. Nealon et al.   ACS Catalysis

Identification of ketone reductase ChKRED20 from the genome of Chryseobacterium sp. CA49 for highly efficient anti-Prelog reduction of 3,5-bis(trifluoromethyl)acetophenone

(2014) Yan Liu et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Characterization of a robust anti-Prelog short-chain dehydrogenase/reductase ChKRED20 from Chryseobacterium sp. CA49

(2014) Tuo-Xian Tang et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Access to Lactone Building Blocks via Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactonization

(2013) Selin Kara et al.   ACS Catalysis

Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis

(2012) Sabrina Kille et al.   ACS Synthetic Biology

Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs

(2011) D. Muñoz Solano et al.   BIORESOURCE TECHNOLOGY

Asymmetric Chemoenzymatic Synthesis of Miconazole and Econazole Enantiomers. The Importance of Chirality in Their Biological Evaluation

(2011) Juan Mangas-Sánchez et al.   JOURNAL OF ORGANIC CHEMISTRY

Ticagrelor

(2011) Kurt Huber et al.   NATURE REVIEWS DRUG DISCOVERY

Recent advances in alcohol dehydrogenase-catalyzed asymmetric production of hydrophobic alcohols

(2011) Musa M. Musa et al.   Catalysis Science & Technology

Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

(2010) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Practical chiral alcohol manufacture using ketoreductases

(2010) Gjalt W Huisman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biochemical characterization of a recombinant short-chain NAD(H)-dependent dehydrogenase/reductase from Sulfolobus acidocaldarius

(2010) Angela Pennacchio et al.   EXTREMOPHILES

Antiplatelet therapies for the treatment of cardiovascular disease

(2010) Alan D. Michelson   NATURE REVIEWS DRUG DISCOVERY

A green-by-design biocatalytic process for atorvastatin intermediate

(2009) Steven K. Ma et al.   GREEN CHEMISTRY

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

QMEAN server for protein model quality estimation

(2009) Pascal Benkert et al.   NUCLEIC ACIDS RESEARCH

Development of a Practical Biocatalytic Process for (R)-2-Methylpentanol

(2009) Owen W. Gooding et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Addressing the Numbers Problem in Directed Evolution

(2008) Manfred T. Reetz et al.   CHEMBIOCHEM

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH

Highly Efficient Route for Enantioselective Preparation of Chlorohydrins via Dynamic Kinetic Resolution

(2008) Annika Träff et al.   ORGANIC LETTERS

Preparative Asymmetric Synthesis of 4,4-Dimethoxytetrahydro-2H-pyran-3-ol with a Ketone Reductase and in Situ Cofactor Recycling using Glucose Dehydrogenase

(2008) Birgit Kosjek et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

New opportunities for biocatalysis: making pharmaceutical processes greener

(2008) John M. Woodley   TRENDS IN BIOTECHNOLOGY