Recent advances on halohydrin dehalogenases—from enzyme identification to novel biocatalytic applications

Biochemical and biocatalytic characterization of 17 novel halohydrin dehalogenases

(2016) Julia Koopmeiners et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improvement of enantioselectivity of the B-type halohydrin hydrogen-halide-lyase from Corynebacterium sp. N-1074

(2016) Fumiaki Watanabe et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis

(2016) Jana Trifinopoulos et al.   NUCLEIC ACIDS RESEARCH

Oxazolidinone Synthesis through Halohydrin Dehalogenase- Catalyzed Dynamic Kinetic Resolution

(2015) Ana Mikleušević et al.   ADVANCED SYNTHESIS & CATALYSIS

Exploring the Enantioselective Mechanism of Halohydrin Dehalogenase from Agrobacterium radiobacter AD1 by Iterative Saturation Mutagenesis

(2015) Chao Guo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

An efficient high-throughput screening assay for rapid directed evolution of halohydrin dehalogenase for preparation of β-substituted alcohols

(2015) Nan-Wei Wan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A high-throughput adrenaline test for the exploration of the catalytic potential of halohydrin dehalogenases in epoxide ring-opening reactions

(2015) Lixia Tang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Efficient synthesis of (S)-epichlorohydrin in high yield by cascade biocatalysis with halohydrin dehalogenase and epoxide hydrolase mutants

(2015) Feng Xue et al.   CATALYSIS COMMUNICATIONS

A One-Step Biocatalytic Process for (S)-4-Chloro-3-hydroxybutyronitrile using Halohydrin Dehalogenase: A Chiral Building Block for Atorvastatin

(2015) Nan-Wei Wan et al.   ChemCatChem

Efficient Biosynthesis of Ethyl (R)-3-Hydroxyglutarate through a One-Pot Bienzymatic Cascade of Halohydrin Dehalogenase and Nitrilase

(2015) Peiyuan Yao et al.   ChemCatChem

A single point mutation enhances hydroxynitrile synthesis by halohydrin dehalogenase

(2015) Marcus Schallmey et al.   ENZYME AND MICROBIAL TECHNOLOGY

Improvement of the thermostability and activity of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by engineering C-terminal amino acids

(2015) Xiong Wang et al.   JOURNAL OF BIOTECHNOLOGY

An enzymatic method for determination of azide and cyanide in aqueous phase

(2015) Nan-Wei Wan et al.   JOURNAL OF BIOTECHNOLOGY

MDC-Analyzer-facilitated combinatorial strategy for improving the activity and stability of halohydrin dehalogenase from Agrobacterium radiobacter AD1

(2015) Xiong Wang et al.   JOURNAL OF BIOTECHNOLOGY

Biochemical characterization and biosynthetic application of a halohydrin dehalogenase from Tistrella mobilis ZJB1405

(2015) Feng Xue et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Crystal structures of halohydrin hydrogen-halide-lyases fromCorynebacteriumsp. N-1074

(2015) Fumiaki Watanabe et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Expanding the Halohydrin Dehalogenase Enzyme Family: Identification of Novel Enzymes by Database Mining

(2014) Marcus Schallmey et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Purification, Gene Cloning, and Characterization of a Novel Halohydrin Dehalogenase from Agromyces mediolanus ZJB120203

(2014) Feng Xue et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Identification of halohydrin dehalogenase mutants that resist COBE inhibition

(2014) Shao-Yun Chen et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Immobilized Synthetic Pathway for Biodegradation of Toxic Recalcitrant Pollutant 1,2,3-Trichloropropane

(2014) Pavel Dvorak et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Enhancement of (S)-2,3-dichloro-1-propanol production by recombinant whole-cell biocatalyst in n-heptane–aqueous biphasic system

(2014) Shu-Ping Zou et al.   JOURNAL OF BIOTECHNOLOGY

Expression, characterization, and improvement of a newly cloned halohydrin dehalogenase from Agrobacterium tumefaciens and its application in production of epichlorohydrin

(2014) Zhi-Qiang Liu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate in high concentration using a novel halohydrin dehalogenase HHDH-PL from Parvibaculum lavamentivorans DS-1

(2014) Nan-Wei Wan et al.   RSC Advances

Multi-Enzymatic Biosynthesis of Chiral β-Hydroxy Nitriles through Co-Expression of Oxidoreductase and Halohydrin Dehalogenase

(2013) Shao-Yun Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Production of (R)-epichlorohydrin from 1,3-dichloro-2-propanol by two-step biocatalysis using haloalcohol dehalogenase and epoxide hydrolase in two-phase system

(2013) Huo-Xi Jin et al.   BIOCHEMICAL ENGINEERING JOURNAL

Exploring the potential of megaprimer PCR in conjunction with orthogonal array design for mutagenesis library construction

(2013) Lixia Tang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Enhanced biotransformation of 1,3-dichloro-2-propanol to epichlorohydrin via resin-based in situ product removal process

(2013) Shu-Ping Zou et al.   BIOTECHNOLOGY LETTERS

Biocatalytic and Structural Properties of a Highly Engineered Halohydrin Dehalogenase

(2013) Marcus Schallmey et al.   CHEMBIOCHEM

Key Residues for Controlling Enantioselectivity of Halohydrin Dehalogenase from Arthrobacter sp. Strain AD2, Revealed by Structure-Guided Directed Evolution

(2012) Lixia Tang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Properties and biotechnological applications of halohydrin dehalogenases: current state and future perspectives

(2012) Zhong-Yu You et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Nitrite-mediated synthesis of chiral epichlorohydrin using halohydrin dehalogenase from Agrobacterium radiobacter AD1

(2012) Huo-Xi Jin et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Catalytic activity of halohydrin dehalogenases towards spiroepoxides

(2012) Maja Majerić Elenkov et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enhancing the recombinant protein expression of halohydrin dehalogenase HheA in Escherichia coli by applying a codon optimization strategy

(2011) Lixia Tang et al.   ENZYME AND MICROBIAL TECHNOLOGY

Combining Designer Cells and Click Chemistry for a One-Pot Four-Step Preparation of Enantiopure β-Hydroxytriazoles

(2010) Wiktor Szymanski et al.   ADVANCED SYNTHESIS & CATALYSIS

webPRANK: a phylogeny-aware multiple sequence aligner with interactive alignment browser

(2010) Ari Löytynoja et al.   BMC BIOINFORMATICS

Enzymatic Removal of 3-Monochloropropanediol (3-MCPD) and its Esters from Oils

(2010) Uwe T. Bornscheuer et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

A high-throughput colorimetric assay for screening halohydrin dehalogenase saturation mutagenesis libraries

(2010) Lixia Tang et al.   JOURNAL OF BIOTECHNOLOGY

Biocatalytic Cascade for the Synthesis of Enantiopure β-Azidoalcohols and β-Hydroxynitriles

(2009) Joerg H. Schrittwieser et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantiocomplementary Chemoenzymatic Asymmetric Synthesis of (R)- and (S)-Chromanemethanol

(2009) Michael Fuchs et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A green-by-design biocatalytic process for atorvastatin intermediate

(2009) Steven K. Ma et al.   GREEN CHEMISTRY

Directed evolution of a Baeyer–Villiger monooxygenase to enhance enantioselectivity

(2008) Anett Kirschner et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening

(2008) Ghannia Hasnaoui-Dijoux et al.   CHEMBIOCHEM

Formation of Enantiopure 5-Substituted Oxazolidinones through Enzyme-Catalysed Kinetic Resolution of Epoxides

(2008) Maja Majerić Elenkov et al.   ORGANIC LETTERS