Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 97, Issue 1, Pages 9-21Publisher
SPRINGER
DOI: 10.1007/s00253-012-4523-0
Keywords
Halogenated organic compounds; Halohydrin dehalogenases; Properties; Biotechnological applications
Categories
Funding
- National Basic Research Program of China (973 Program) [2011CB710806]
- National Natural Science Foundation of China [31170761]
- Natural Science Foundation of Zhejiang Province [Z4080032, R3110155]
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Halohydrin dehalogenases (HHDHs) are lyases that catalyze the cleavage of carbon-halogen bond of halohydrins. They also can catalyze the reverse reaction in the presence of nucleophiles such as cyanide, azide, and nitrite ions. HHDHs have been recognized as the ideal tools for the degradation of various halogenated environmental pollutants. Moreover, they can be used as biocatalysts for the kinetic resolution of halohydrins and epoxides, and for the preparation of various substituted alcohols. This review is mainly focused on the current status of research on HHDHs, highlighting the production, characterization, structures and mechanism, protein engineering, and biotechnological applications of HHDHs.
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