Adipose-tissue plasticity in health and disease

Brown adipose tissue is associated with cardiometabolic health

(2021) Tobias Becher et al.   NATURE MEDICINE

100th Anniversary of the discovery of insulin Perspective: Insulin and Adipose Tissue Fatty Acid Metabolism

(2021) André C. Carpentier   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

(2021) Mengle Shao et al.   Cell Stem Cell

A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting

(2021) Ximeng Han et al.   Cell Stem Cell

Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue

(2021) Jooman Park et al.   DEVELOPMENTAL CELL

Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis

(2021) Hai P. Nguyen et al.   DEVELOPMENTAL CELL

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

(2021) Andrew D. Hildreth et al.   NATURE IMMUNOLOGY

The cellular and functional complexity of thermogenic fat

(2021) Paul Cohen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

(2021) Olivia Sveidahl Johansen et al.   CELL

IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2

(2021) Emily L. Goldberg et al.   Cell Metabolism

Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual

(2021) Bo Shan et al.   GENES & DEVELOPMENT

Mesothelial cells are not a source of adipocytes in mice

(2021) Gregory P. Westcott et al.   Cell Reports

ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes

(2021) Mengle Shao et al.   GENES & DEVELOPMENT

Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis

(2021) Megan Stefkovich et al.   Molecular Metabolism

The critical role of MMP14 in adipose tissue remodeling during obesity

(2020) Xin Li et al.   MOLECULAR AND CELLULAR BIOLOGY

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

(2020) Bo Hu et al.   NATURE

Parallel Lineage-Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor

(2020) Paola Cattaneo et al.   Cell Reports

Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes

(2020) Anthony R. Angueira et al.   Cell Reports

Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

(2020) Federica Zatterale et al.   Frontiers in Physiology

Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis

(2020) Chengyi Sun et al.   Cell Stem Cell

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

(2020) Brett A. Shook et al.   Cell Stem Cell

US life expectancy stalls due to cardiovascular disease, not drug deaths

(2020) Neil K. Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of insulin resistance related to white, beige, and brown adipocytes

(2020) Michael P. Czech   Molecular Metabolism

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

(2020) Yasuo Oguri et al.   CELL

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

(2020) Felipe Henriques et al.   Cell Reports

HIV and antiretroviral therapy-related fat alterations

(2020) John R. Koethe et al.   Nature Reviews Disease Primers

Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

(2020) Connie W.Y. Ha et al.   CELL

Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity

(2020) Radiana Ferrero et al.   TRENDS IN CELL BIOLOGY

Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution

(2020) Anitta Kinga Sárvári et al.   Cell Metabolism

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity

(2019) Mary Jane West-Eberhard   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Assembling the adipose organ: adipocyte lineage segregation and adipogenesis in vivo

(2019) Zachary L. Sebo et al.   DEVELOPMENT

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism

(2019) Stephanie Pearson et al.   GENES & DEVELOPMENT

Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis

(2019) Xing Zeng et al.   NATURE

Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans

(2019) Jun Yoshino et al.   Obesity

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

(2019) David Merrick et al.   SCIENCE

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

(2019) Arthe Raajendiran et al.   Cell Reports

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Focus on dedifferentiated adipocytes: characteristics, mechanisms, and possible applications

(2019) Julie Anne Côté et al.   CELL AND TISSUE RESEARCH

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

(2019) Wenshan Wang et al.   Cell Metabolism

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

(2019) Jan-Bernd Funcke et al.   JOURNAL OF LIPID RESEARCH

During adipocyte remodeling, lipid droplet configurations regulate insulin sensitivity through F/G-actin reorganization

(2019) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells

(2019) D. Estève et al.   Nature Communications

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

(2019) Birgit Gustafson et al.   Nature Communications

3D analysis of the whole subcutaneous adipose tissue reveals a complex spatial network of interconnected lobules with heterogeneous browning ability

(2019) Jules Dichamp et al.   Scientific Reports

Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes

(2019) Jingli Lu et al.   Frontiers in Immunology

ComBATing aging—does increased brown adipose tissue activity confer longevity?

(2019) Justin Darcy et al.   GeroScience

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

(2019) Raul German Spallanzani et al.   Science Immunology

Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

(2019) T. Mahlakõiv et al.   Science Immunology

Cellular Origins of Beige Fat Cells Revisited

(2019) Mengle Shao et al.   DIABETES

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms

(2019) Peng Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis

(2019) Geneviève Marcelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolically healthy obesity: facts and fantasies

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

(2019) Lavanya Vishvanath et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

(2019) Su Myung Jung et al.   MOLECULAR CELL

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Adipose lipid turnover and long-term changes in body weight

(2019) P. Arner et al.   NATURE MEDICINE

Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis

(2019) Keren I. Hilgendorf et al.   CELL

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

(2019) Shangang Zhao et al.   Cell Metabolism

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

(2019) Anying Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

(2019) Zhuzhen Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR signaling in Brown and Beige adipocytes: implications for thermogenesis and obesity

(2019) Yuqing Ye et al.   Nutrition & Metabolism

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

(2019) Prashant Rajbhandari et al.   eLife

Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

(2018) Vuong Cat Khanh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

(2018) Hyun Cheol Roh et al.   Cell Metabolism

An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents

(2018) Fang Zhang et al.   Cell Metabolism

Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis

(2018) Yutaka Hasegawa et al.   Cell Metabolism

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation

(2018) Qiong A. Wang et al.   Cell Metabolism

Deconstructing Adipogenesis Induced by β3-Adrenergic Receptor Activation with Single-Cell Expression Profiling

(2018) Rayanne B. Burl et al.   Cell Metabolism

Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

(2018) Jingyi Chi et al.   Cell Metabolism

Anatomical, Physiological, and Functional Diversity of Adipose Tissue

(2018) Rachel K. Zwick et al.   Cell Metabolism

Leptin and the maintenance of elevated body weight

(2018) Warren W. Pan et al.   NATURE REVIEWS NEUROSCIENCE

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

(2018) David A. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

(2018) Mengle Shao et al.   Nature Communications

Whole-tissue 3D imaging reveals intra-adipose sympathetic plasticity regulated by NGF-TrkA signal in cold-induced beiging

(2018) Ying Cao et al.   Protein & Cell

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

Obesity, Fat Mass and Immune System: Role for Leptin

(2018) Vera Francisco et al.   Frontiers in Physiology

Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing

(2018) Elsie Gonzalez-Hurtado et al.   Molecular Metabolism

Three-dimensional volume fluorescence-imaging of vascular plasticity in adipose tissues

(2018) Ying Cao et al.   Molecular Metabolism

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

A stromal cell population that inhibits adipogenesis in mammalian fat depots

(2018) Petra C. Schwalie et al.   NATURE

Metabolites as regulators of insulin sensitivity and metabolism

(2018) Qin Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

(2018) Chelsea Hepler et al.   eLife

Thermal stress induces glycolytic beige fat formation via a myogenic state

(2018) Yong Chen et al.   NATURE

Transcriptional Control of Brown and Beige Fat Development and Function

(2018) Suzanne N. Shapira et al.   Obesity

Changes in regional body fat, lean body mass and body shape in trans persons using cross-sex hormonal therapy: results from a multicenter prospective study

(2017) M Klaver et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Subcutaneous fat loss is greater than visceral fat loss with diet and exercise, weight-loss promoting drugs and bariatric surgery: a critical review and meta-analysis

(2017) C Merlotti et al.   INTERNATIONAL JOURNAL OF OBESITY

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Simple mechanical cues could explain adipose tissue morphology

(2017) D. Peurichard et al.   JOURNAL OF THEORETICAL BIOLOGY

The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment

(2017) Chelsea Hepler et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

(2017) Katrin Fischer et al.   NATURE MEDICINE

Plasticity of adipose tissue in response to fasting and refeeding in male mice

(2017) Hao-Neng Tang et al.   Nutrition & Metabolism

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

(2017) Claire L. Donohoe et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Immunological Functions of the Omentum

(2017) Selene Meza-Perez et al.   TRENDS IN IMMUNOLOGY

Relationship Among Body Fat Percentage, Body Mass Index, and All-Cause Mortality

(2016) Raj Padwal et al.   ANNALS OF INTERNAL MEDICINE

Central neural control of thermoregulation and brown adipose tissue

(2016) Shaun F. Morrison   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Adipocyte lipolysis and insulin resistance

(2016) Pauline Morigny et al.   BIOCHIMIE

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

(2016) Mengle Shao et al.   Cell Metabolism

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

(2016) Lavanya Vishvanath et al.   Cell Metabolism

The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

(2016) Elise Jeffery et al.   Cell Metabolism

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

(2016) Reema P. Vazirani et al.   DIABETES

Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

(2016) Tracey McLaughlin et al.   DIABETES

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

(2016) Cassie M. Tran et al.   DIABETES

De Novo Lipogenesis Products and Endogenous Lipokines

(2016) Mustafa Yilmaz et al.   DIABETES

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

(2016) V. Albert et al.   EMBO Molecular Medicine

Hyperandrogenism Accompanies Increased Intra-Abdominal Fat Storage in Normal Weight Polycystic Ovary Syndrome Women

(2016) Daniel A. Dumesic et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice

(2016) Pengpeng Bi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

(2016) Emanuele Di Angelantonio et al.   LANCET

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

(2016) Luca A Lotta et al.   NATURE GENETICS

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation

(2016) Audrey Y Chu et al.   NATURE GENETICS

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Regionalization of browning revealed by whole subcutaneous adipose tissue imaging

(2016) Corinne Barreau et al.   Obesity

Emerging Complexities in Adipocyte Origins and Identity

(2016) Joan Sanchez-Gurmaches et al.   TRENDS IN CELL BIOLOGY

Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16

(2016) Hanying Ding et al.   Nature Communications

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

(2016) Daniel C. Berry et al.   Nature Communications

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

(2016) Yuefeng Tang et al.   Nature Communications

Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study

(2016) Se-Hong Kim et al.   Diabetology & Metabolic Syndrome

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism

(2016) Mee-Sup Yoon   Nutrients

Lack of AKT in adipocytes causes severe lipodystrophy

(2016) Abigail L. Shearin et al.   Molecular Metabolism

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

(2016) Rachel R. Stine et al.   Molecular Metabolism

mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold

(2016) Sébastien M. Labbé et al.   Scientific Reports

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Perilipin+embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion

(2015) Ki Yong Hong et al.   DEVELOPMENT

Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes

(2015) Juan R. Acosta et al.   DIABETOLOGIA

Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice

(2015) Matthew J. During et al.   ENDOCRINOLOGY

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity

(2015) Tomoaki Iwayama et al.   GENES & DEVELOPMENT

Large adipocytes function as antigen-presenting cells to activate CD4+ T cells via upregulating MHCII in obesity

(2015) L Xiao et al.   INTERNATIONAL JOURNAL OF OBESITY

Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity

(2015) Elise Jeffery et al.   NATURE CELL BIOLOGY

Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements

(2015) Thomas S. Morley et al.   Nature Communications

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

Highly Selective In Vivo Labeling of Subcutaneous White Adipocyte Precursors with Prx1-Cre

(2015) Joan Sanchez-Gurmaches et al.   Stem Cell Reports

Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance

(2014) Myriam Aouadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance

(2014) Soo M. Kim et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Antiangiogenic Actions of Vascular Endothelial Growth Factor-A 165 b, an Inhibitory Isoform of Vascular Endothelial Growth Factor-A, in Human Obesity

(2014) Doan T.M. Ngo et al.   CIRCULATION

Changes in Subcutaneous Fat Cell Volume and Insulin Sensitivity After Weight Loss

(2014) Daniel P. Andersson et al.   DIABETES CARE

Vascular rarefaction mediates whitening of brown fat in obesity

(2014) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Human adipocyte function is impacted by mechanical cues

(2014) V Pellegrinelli et al.   JOURNAL OF PATHOLOGY

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

(2014) You-Ying Chau et al.   NATURE CELL BIOLOGY

Regulation of adipocyte lipolysis

(2014) Gema Frühbeck et al.   NUTRITION RESEARCH REVIEWS

Adipocyte Hypertrophy, Inflammation and Fibrosis Characterize Subcutaneous Adipose Tissue of Healthy, Non-Obese Subjects Predisposed to Type 2 Diabetes

(2014) A. M. Josefin Henninger et al.   PLoS One

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

(2014) A. R. Majithia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipocyte dysfunction, inflammation and metabolic syndrome

(2014) Nora Klöting et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

PPARγ and the global map of adipogenesis and beyond

(2014) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Independent Stem Cell Lineages Regulate Adipose Organogenesis and Adipose Homeostasis

(2014) Yuwei Jiang et al.   Cell Reports

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

(2014) Kai Sun et al.   Molecular Metabolism

Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity

(2013) Mi-Jeong Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue

(2013) D. Adam Young et al.   BIOMATERIALS

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Fibrosis and Adipose Tissue Dysfunction

(2013) Kai Sun et al.   Cell Metabolism

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

(2013) Yun-Hee Lee et al.   Cell Metabolism

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

(2013) Claudio J. Villanueva et al.   Cell Metabolism

Weighing in on Adipocyte Precursors

(2013) Ryan Berry et al.   Cell Metabolism

Regulation of human subcutaneous adipose tissue blood flow

(2013) K N Frayn et al.   INTERNATIONAL JOURNAL OF OBESITY

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

(2013) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Characterization of the adipocyte cellular lineage in vivo

(2013) Ryan Berry et al.   NATURE CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Molecular and morphologic characterization of superficial- and deep-subcutaneous adipose tissue subdivisions in human obesity

(2013) Raffaella Cancello et al.   Obesity

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

(2013) Jonathan Mowers et al.   eLife

Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity

(2013) Lauren K Meyer et al.   Adipocyte

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripheral fat loss and decline in adipogenesis in older humans

(2012) Giuseppe Caso et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Selective Inhibition of Hypoxia-Inducible Factor 1  Ameliorates Adipose Tissue Dysfunction

(2012) K. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

(2012) Christine M Kusminski et al.   NATURE MEDICINE

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

(2012) Aparna Pal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Visceral fat and metabolic inflammation: the portal theory revisited

(2012) F. Item et al.   Obesity Reviews

Seeking the source of adipocytes in adult white adipose tissues

(2012) Yun-Hee Lee et al.   Adipocyte

Thiazolidinediones Regulate Adipose Lineage Dynamics

(2011) Wei Tang et al.   Cell Metabolism

Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle

(2011) A. Uezumi et al.   JOURNAL OF CELL SCIENCE

Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject

(2011) Jurga Laurencikiene et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Rapid Cellular Turnover in Adipose Tissue

(2011) Alessandra Rigamonti et al.   PLoS One

Transcriptional networks and chromatin remodeling controlling adipogenesis

(2011) Rasmus Siersbæk et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries

(2010) Brandon S.J. Davies et al.   Cell Metabolism

Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors

(2010) L.-E. Zaragosi et al.   DIABETES

The Portal Theory Supported by Venous Drainage-Selective Fat Transplantation

(2010) J. M. Rytka et al.   DIABETES

Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss

(2010) A. Divoux et al.   DIABETES

Propagation of adipogenic signals through an epigenomic transition state

(2010) D. J. Steger et al.   GENES & DEVELOPMENT

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A long look at obesity

(2010) David Haslam et al.   LANCET

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

(2009) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging study

(2009) Wei Shen et al.   Nutrition & Metabolism

BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

(2009) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering

(2008) Rachel P. Wildman   ARCHIVES OF INTERNAL MEDICINE

Identification of White Adipocyte Progenitor Cells In Vivo

(2008) Matthew S. Rodeheffer et al.   CELL

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Increased visceral fat and decreased energy expenditure during the menopausal transition

(2008) J C Lovejoy et al.   INTERNATIONAL JOURNAL OF OBESITY

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

White Fat Progenitor Cells Reside in the Adipose Vasculature

(2008) W. Tang et al.   SCIENCE