ComBATing aging—does increased brown adipose tissue activity confer longevity?

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

(2018) Dorothy E. Vatner et al.   AGING CELL

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

(2018) Kristin I. Stanford et al.   Cell Metabolism

Assessment of the Aging of the Brown Adipose Tissue by 18F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna−/−

(2018) Zhengjie Wang et al.   Contrast Media & Molecular Imaging

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

(2018) Rubén Cereijo et al.   Cell Metabolism

Brown Adipose Tissue Energy Metabolism in Humans

(2018) André C. Carpentier et al.   Frontiers in Endocrinology

Increased environmental temperature normalizes energy metabolism outputs between normal and Ames dwarf mice

(2018) Justin Darcy et al.   Aging-US

Changes in adipose tissue cellular composition during obesity and aging as a cause of metabolic dysregulation

(2017) Kari Martyniak et al.   EXPERIMENTAL GERONTOLOGY

Age-Induced Changes in White, Brite, and Brown Adipose Depots: A Mini-Review

(2017) Markus Schosserer et al.   GERONTOLOGY

Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice

(2017) Leidyanne Ferreira Gonçalves et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

(2017) Matthew J. Emmett et al.   NATURE

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Blocking FSH induces thermogenic adipose tissue and reduces body fat

(2017) Peng Liu et al.   NATURE

Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

(2017) Roksana M Pirzgalska et al.   NATURE MEDICINE

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

(2017) Michael B. Stout et al.   PHYSIOLOGY

Epigenetic Regulation of the Thermogenic Adipose Program

(2017) Audrey Sambeat et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice

(2016) Justin Darcy et al.   ENDOCRINOLOGY

Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function

(2016) Matteo Oliverio et al.   NATURE CELL BIOLOGY

Brown adipose tissue as a secretory organ

(2016) Francesc Villarroya et al.   Nature Reviews Endocrinology

Brown adipose tissue transplantation ameliorates polycystic ovary syndrome

(2016) Xiaoxue Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

(2016) Yong Chen et al.   Nature Communications

Translating the Science of Aging into Therapeutic Interventions

(2016) James L. Kirkland   Cold Spring Harbor Perspectives in Medicine

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

(2016) Michael B. Stout et al.   Aging-US

Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant

(2015) Subhadra C. Gunawardana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

(2015) Yohei Abe et al.   Nature Communications

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

(2015) Michael B. Stout et al.   Oncotarget

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Brown Fat in Humans: Consensus Points and Experimental Guidelines

(2014) Aaron M. Cypess et al.   Cell Metabolism

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation

(2014) Martin Pal et al.   IMMUNOLOGY AND CELL BIOLOGY

Mitochondrial uncoupling as a regulator of life-history trajectories in birds: an experimental study in the zebra finch

(2014) A. Stier et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Role of forkhead box protein A3 in age-associated metabolic decline

(2014) Xinran Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brown adipose tissue transplantation improves whole-body energy metabolism

(2013) Xiaomeng Liu et al.   CELL RESEARCH

Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes

(2013) H. Sacks et al.   DIABETES

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

Aging-Associated Reductions in Lipolytic and Mitochondrial Proteins in Mouse Adipose Tissue Are Not Rescued by Metformin Treatment

(2013) E. Mennes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Evaluation of growth hormone (GH) action in mice: Discovery of GH receptor antagonists and clinical indications

(2013) John J. Kopchick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

(2013) Haruya Ohno et al.   NATURE

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity

(2013) Andrzej Bartke et al.   PHYSIOLOGICAL REVIEWS

Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation)

(2013) Zheng Zhu et al.   PHYSIOLOGY & BEHAVIOR

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

The Implication of Brown Adipose Tissue for Humans

(2011) Eric Ravussin et al.   Annual Review of Nutrition

Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity

(2011) Giuseppina Rose et al.   EXPERIMENTAL GERONTOLOGY

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Further Support to the Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity

(2011) Giuseppina Rose et al.   PLoS One

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Perilipin Controls Lipolysis by Regulating the Interactions of AB-hydrolase Containing 5 (Abhd5) and Adipose Triglyceride Lipase (Atgl)

(2009) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

(2009) Reyhan Westbrook et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE