Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

The Glucose Sensor ChREBP Links De Novo Lipogenesis to PPARγ Activity and Adipocyte Differentiation

(2015) Nicole Witte et al.   ENDOCRINOLOGY

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans

(2014) C Lawrence Kien et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model

(2014) A. Fuhrmann et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux

(2014) Yolanda F. Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease

(2014) Chien-Min Hung et al.   Cell Reports

Characterization of Cre recombinase models for the study of adipose tissue

(2014) Elise Jeffery et al.   Adipocyte

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Insulin signalling mechanisms for triacylglycerol storage

(2013) M. P. Czech et al.   DIABETOLOGIA

Recent progress on the role of ChREBP in glucose and lipid metabolism [Review]

(2013) Katsumi Iizuka   ENDOCRINE JOURNAL

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Control of Hepatic Lipid Metabolism by SREBP and ChREBP

(2013) Xu Xu et al.   SEMINARS IN LIVER DISEASE

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

(2012) Irfan J. Lodhi et al.   Cell Metabolism

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

Decreased Transcription of ChREBP- /  Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia

(2012) R. Kursawe et al.   DIABETES

A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults

(2012) C. L. Kien et al.   DIABETES

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

(2012) Fadila Benhamed et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Adipose-Specific Gene Deletion Model Demonstrates Potential Pitfalls of Existing Methods

(2012) Shannon E. Mullican et al.   MOLECULAR ENDOCRINOLOGY

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

(2011) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity

(2010) Damir Zadravec et al.   FASEB JOURNAL

Dyslipidemia following kidney transplantation: Diagnosis and treatment

(2009) Stéphanie Badiou et al.   Current Diabetes Reports

High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice

(2009) Maaike H. Oosterveer et al.   PLoS One

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Review article: New-onset diabetes after transplantation

(2008) KAI MING CHOW et al.   NEPHROLOGY