IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2

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Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline

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The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance

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Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

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Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling

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Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming

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A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

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(2019) Ben W. Dulken et al.   NATURE

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

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Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

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Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

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Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

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γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

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Tissue signals imprint ILC2 identity with anticipatory function

(2018) Roberto R. Ricardo-Gonzalez et al.   NATURE IMMUNOLOGY

Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life

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Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

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Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

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Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

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Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

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Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

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Depletion of fat-resident Treg cells prevents age-associated insulin resistance

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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

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Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

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Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

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Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

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Type 2 innate lymphoid cells control eosinophil homeostasis

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Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue

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Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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