Can dynamic in vitro digestion systems mimic the physiological reality?

Eubacterium limosum Activates Isoxanthohumol from Hops (Humulus lupulus L.) into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in Rat Intestine

(2018) Sam Possemiers et al.   JOURNAL OF NUTRITION

Preparation and characterization of a packed bead immobilized trypsin reactor integrated into a PDMS microfluidic chip for rapid protein digestion

(2017) Adam Kecskemeti et al.   TALANTA

Impact of human milk pasteurization on the kinetics of peptide release during in vitro dynamic term newborn digestion

(2016) Amélie Deglaire et al.   ELECTROPHORESIS

Impact of pasteurization of human milk on preterm newborn in vitro digestion: Gastrointestinal disintegration, lipolysis and proteolysis

(2016) Samira C. de Oliveira et al.   FOOD CHEMISTRY

Survival of cheese-ripening microorganisms in a dynamic simulator of the gastrointestinal tract

(2016) Nadège Adouard et al.   FOOD MICROBIOLOGY

Holder pasteurization impacts the proteolysis, lipolysis and disintegration of human milk under in vitro dynamic term newborn digestion

(2016) Samira C. de Oliveira et al.   FOOD RESEARCH INTERNATIONAL

Development of an advanced in vitro model of the stomach and its evaluation versus human gastric physiology

(2016) Susann Bellmann et al.   FOOD RESEARCH INTERNATIONAL

Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms

(2016) Miriam Verwei et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Herring roe protein has a high digestible indispensable amino acid score (DIAAS) using a dynamic in vitro gastrointestinal model

(2016) Robert Havenaar et al.   NUTRITION RESEARCH

Increased EHEC survival and virulence gene expression indicate an enhanced pathogenicity upon simulated pediatric gastrointestinal conditions

(2016) Charlène Roussel et al.   PEDIATRIC RESEARCH

Enterohemorrhagic Escherichia coli infection has donor-dependent effect on human gut microbiota and may be antagonized by probiotic yeast during interaction with Peyer’s patches

(2015) J. Thévenot et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Development and validation of a new dynamic computer-controlled model of the human stomach and small intestine

(2015) Aurélie Guerra et al.   BIOTECHNOLOGY AND BIOENGINEERING

Peptide mapping during dynamic gastric digestion of heated and unheated skimmed milk powder

(2015) Laura Sánchez-Rivera et al.   FOOD RESEARCH INTERNATIONAL

Application of a new Dynamic Gastrointestinal Simulator (SIMGI) to study the impact of red wine in colonic metabolism

(2015) C. Cueva et al.   FOOD RESEARCH INTERNATIONAL

Evaluation of an optimal preparation of human standardized fecal inocula for in vitro fermentation studies

(2015) Marisol Aguirre et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Development of human colonic microbiota in the computer-controlled dynamic SIMulator of the GastroIntestinal tract SIMGI

(2015) Elvira Barroso et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

The Design, Operation, and Application of a Dynamic Gastric Model

(2015) M. J. S. Wickham et al.   DISSOLUTION TECHNOLOGIES

The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro

(2014) Massimo Marzorati et al.   BMC MICROBIOLOGY

Gastric digestion of α-lactalbumin in adult human subjects using capsule endoscopy and nasogastric tube sampling

(2014) Louise M. Sullivan et al.   BRITISH JOURNAL OF NUTRITION

A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices

(2014) Joost Westerhout et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Gastric pH Distribution and Mixing of Soft and Rigid Food Particles in the Stomach using a Dual-Marker Technique

(2014) Gail M. Bornhorst et al.   Food Biophysics

Tracking the in vivo release of bioactive peptides in the gut during digestion: Mass spectrometry peptidomic characterization of effluents collected in the gut of dairy matrix fed mini-pigs

(2014) Florence Barbé et al.   FOOD RESEARCH INTERNATIONAL

To pool or not to pool? Impact of the use of individual and pooled fecal samples for in vitro fermentation studies

(2014) Marisol Aguirre et al.   JOURNAL OF MICROBIOLOGICAL METHODS

In Vitro Characterization of the Impact of Different Substrates on Metabolite Production, Energy Extraction and Composition of Gut Microbiota from Lean and Obese Subjects

(2014) Marisol Aguirre et al.   PLoS One

Effect of gel structure on the gastric digestion of whey protein emulsion gels

(2014) Qing Guo et al.   Soft Matter

A microfluidic device to study the digestion of trapped lipid droplets

(2014) Sébastien Marze et al.   Food & Function

Rheological Properties and Textural Attributes of Cooked Brown and White Rice During Gastric Digestion in Vivo

(2013) Gail M. Bornhorst et al.   Food Biophysics

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

(2013) David M. Ribnicky et al.   FOOD CHEMISTRY

Validation of a new in vitro dynamic system to simulate infant digestion

(2013) Olivia Ménard et al.   FOOD CHEMISTRY

In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?

(2013) Robert Havenaar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Digestibility of Transglutaminase Cross-Linked Caseinate versus Native Caseinate in an In Vitro Multicompartmental Model Simulating Young Child and Adult Gastrointestinal Conditions

(2013) Robert Havenaar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan versus Inulin

(2013) Pieter Van den Abbeele et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Profiling of Microbial-Derived Phenolic Metabolites in Human Feces after Moderate Red Wine Intake

(2013) Irene Muñoz-González et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gastric emptying rate and chyme characteristics for cooked brown and white rice mealsin vivo

(2013) Gail M Bornhorst et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus

(2013) Louise Kristine Vigsnaes et al.   Scientific Reports

Microfluidic Flow Cell for Sequential Digestion of Immobilized Proteoliposomes

(2012) Erik T. Jansson et al.   ANALYTICAL CHEMISTRY

Enterohemorrhagic Escherichia coli O157:H7 Survival in anIn VitroModel of the Human Large Intestine and Interactions with Probiotic Yeasts and Resident Microbiota

(2012) Jonathan Thévenot et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effect of galactooligosaccharides andBifidobacterium animalisBb-12 on growth ofLactobacillus amylovorusDSM 16698, microbial community structure, and metabolite production in anin vitrocolonic model set up with human or pig microbiota

(2012) Rafael C.R. Martinez et al.   FEMS MICROBIOLOGY ECOLOGY

Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model

(2012) Pieter Van den Abbeele et al.   ISME Journal

Relevance and challenges in modeling human gastric and small intestinal digestion

(2012) Aurélie Guerra et al.   TRENDS IN BIOTECHNOLOGY

Achieving Antral Grinding Forces in Biorelevant In Vitro Models: Comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with Human In Vivo Data

(2011) Maria Vardakou et al.   AAPS PHARMSCITECH

High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

(2011) Wendy R Russell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats

(2011) Pieter Van den Abbeele et al.   ENVIRONMENTAL MICROBIOLOGY

Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment

(2011) Joan Vermeiren et al.   FEMS MICROBIOLOGY ECOLOGY

Effect of bioprocessing of wheat bran in wholemeal wheat breads on the colonic SCFA production in vitro and postprandial plasma concentrations in men

(2011) Nuria Mateo Anson et al.   FOOD CHEMISTRY

Metabolite Production during in Vitro Colonic Fermentation of Dietary Fiber: Analysis and Comparison of Two European Diets

(2011) Maria Tabernero et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Use of Artificial Digestive Systems to Investigate the Biopharmaceutical Factors Influencing the Survival of Probiotic Yeast During Gastrointestinal Transit in Humans

(2011) Stéphanie Blanquet-Diot et al.   PHARMACEUTICAL RESEARCH

Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli

(2011) Pieter Van den Abbeele et al.   Microbial Biotechnology

Development and Validation of a Continuous In Vitro System Reproducing Some Biotic and Abiotic Factors of the Veal Calf Intestine

(2010) M. Gerard-Champod et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microbial Community Development in a Dynamic Gut Model Is Reproducible, Colon Region Specific, and Selective for Bacteroidetes and Clostridium Cluster IX

(2010) P. Van den Abbeele et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Modeling the Fluid Dynamics in a Human Stomach to Gain Insight of Food Digestion

(2010) M.J. Ferrua et al.   JOURNAL OF FOOD SCIENCE

A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach

(2010) Fanbin Kong et al.   JOURNAL OF FOOD SCIENCE

Bioprocessing of Wheat Bran in Whole Wheat Bread Increases the Bioavailability of Phenolic Acids in Men and Exerts Antiinflammatory Effects ex Vivo

(2010) Nuria Mateo Anson et al.   JOURNAL OF NUTRITION

Evaluating the microbial diversity of an in vitro model of the human large intestine by phylogenetic microarray analysis

(2010) M. Rajilic-Stojanovic et al.   MICROBIOLOGY-SGM

Starch-entrapped microspheres show a beneficial fermentation profile and decrease in potentially harmful bacteria during in vitro fermentation in faecal microbiota obtained from patients with inflammatory bowel disease

(2009) Devin J. Rose et al.   BRITISH JOURNAL OF NUTRITION

Combining the Dynamic TNO-Gastrointestinal Tract System with a Caco-2 Cell Culture Model: Application to the Assessment of Lycopene and α-Tocopherol Bioavailability from a Whole Food

(2009) Emmanuelle Déat et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant and anti-inflammatory capacity of bioaccessible compounds from wheat fractions after gastrointestinal digestion

(2009) Nuria Mateo Anson et al.   JOURNAL OF CEREAL SCIENCE

Every slow-wave impulse is associated with motor activity of the human stomach

(2008) Michael Hocke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety

(2008) Luca Marciani et al.   BRITISH JOURNAL OF NUTRITION

Linking phylogenetic identities of bacteria to starch fermentation in anin vitromodel of the large intestine by RNA-based stable isotope probing

(2008) Petia Kovatcheva-Datchary et al.   ENVIRONMENTAL MICROBIOLOGY

Disintegration of Solid Foods in Human Stomach

(2008) F. Kong et al.   JOURNAL OF FOOD SCIENCE