PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target

Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways

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Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development

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Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation

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The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC

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Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

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Rotavirus in Organ Transplantation: Drug-Virus-Host Interactions

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Valacyclovir combined with artesunate or rapamycin improves the outcome of herpes simplex virus encephalitis in mice compared to antiviral therapy alone

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Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

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mTOR: a pharmacologic target for autophagy regulation

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Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types

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Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

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Virus-induced translational arrest through 4EBP1/2-dependent decay of 5′-TOP mRNAs restricts viral infection

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Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

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Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells

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Catch Me If You Can: The Link between Autophagy and Viruses

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Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis

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Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus

(2014) Yijin Wang et al.   GASTROENTEROLOGY

Rapamycin and everolimus facilitate hepatitis E virus replication: Revealing a basal defense mechanism of PI3K-PKB-mTOR pathway

(2014) Xinying Zhou et al.   JOURNAL OF HEPATOLOGY

Deficiency in Either 4E-BP1 or 4E-BP2 Augments Innate Antiviral Immune Responses

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An Invertebrate Warburg Effect: A Shrimp Virus Achieves Successful Replication by Altering the Host Metabolome via the PI3K-Akt-mTOR Pathway

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Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities

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LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway

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Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

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Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells

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Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine

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The Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway

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Divergent Roles of Autophagy in Virus Infection

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Chikungunya virus–induced autophagy delays caspase-dependent cell death

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Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

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The PI3K/Akt Pathway Contributes to Arenavirus Budding

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HBx induces HepG-2 cells autophagy through PI3K/Akt–mTOR pathway

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Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo

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mTOR regulation of autophagy

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Rapamycin Activates Autophagy and Improves Myelination in Explant Cultures from Neuropathic Mice

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Dominant Inhibition of Akt/Protein Kinase B Signaling by the Matrix Protein of a Negative-Strand RNA Virus

(2010) E. F. Dunn et al.   JOURNAL OF VIROLOGY

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

(2010) B. G. Hale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

(2010) T. Alain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viruses and autophagy

(2009) Sagar B. Kudchodkar et al.   REVIEWS IN MEDICAL VIROLOGY

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE