Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions

Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults

(2020) Chara Litou et al.   PHARMACEUTICAL RESEARCH

Small scale design of experiment investigation of equilibrium solubility in simulated fasted and fed intestinal fluid

(2020) Stephanie McPherson et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Variations in gastrointestinal lipases, pH and bile acid levels with food intake, age and diseases: Possible impact on oral lipid-based drug delivery systems

(2019) Sawsan Amara et al.   ADVANCED DRUG DELIVERY REVIEWS

Co-existing colloidal phases of human duodenal aspirates: Intraindividual fluctuations and interindividual variability in relation to molecular composition

(2019) Philipp A. Elvang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Dissolution behavior of various drugs in different FaSSIF versions

(2019) Lukas Klumpp et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Lipids in the Stomach – Implications for the Evaluation of Food Effects on Oral Drug Absorption

(2018) Mirko Koziolek et al.   PHARMACEUTICAL RESEARCH

The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review

(2018) Christina Pentafragka et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bile Salts Caught in the Act: From Emulsification to Nanostructural Reorganization of Lipid Self-Assemblies

(2018) Amin Sadeghpour et al.   LANGMUIR

Gastric and Duodenal Diclofenac Concentrations in Healthy Volunteers after Intake of the FDA Standard Meal: In Vivo Observations and in Vitro Explorations

(2018) Jari Rubbens et al.   MOLECULAR PHARMACEUTICS

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

(2018) Stephen T. Buckley et al.   Science Translational Medicine

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

(2018) James Butler et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies

(2016) Chara Litou et al.   PHARMACEUTICAL RESEARCH

Advances in the design of fasted state simulating intestinal fluids: FaSSIF-V3

(2015) Alexander Fuchs et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In-vitro simulation of luminal conditions for evaluation of performance of oral drug products: Choosing the appropriate test media

(2015) Constantinos Markopoulos et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies

(2015) M. Koziolek et al.   JOURNAL OF CONTROLLED RELEASE

Intragastric Volume Changes after Intake of a High-Caloric, High-Fat Standard Breakfast in Healthy Human Subjects Investigated by MRI

(2014) Mirko Koziolek et al.   MOLECULAR PHARMACEUTICS

Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities

(2013) Pernille Barbre Pedersen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness

(2013) C. Markopoulos et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Luminal Lipid Phases after Administration of a Triglyceride Solution of Danazol in the Fed State and Their Contribution to the Flux of Danazol Across Caco-2 Cell Monolayers

(2012) Maria Vertzoni et al.   MOLECULAR PHARMACEUTICS

Insights into Intermediate Phases of Human Intestinal Fluids Visualized by Atomic Force Microscopy and Cryo-Transmission Electron Microscopy ex Vivo

(2011) Anette Müllertz et al.   MOLECULAR PHARMACEUTICS

Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults

(2009) Amalia Diakidou et al.   PHARMACEUTICAL RESEARCH

Determination of intralumenal individual bile acids by HPLC with charged aerosol detection

(2008) Maria Vertzoni et al.   JOURNAL OF LIPID RESEARCH

Postprandial Evolution in Composition and Characteristics of Human Duodenal Fluids in Different Nutritional States

(2008) S. Clarysse et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH