In Vitro Methods to Study Colon Release: State of the Art and An Outlook on New Strategies for Better In-Vitro Biorelevant Release Media

Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals

(2019) Panna Vass et al.   JOURNAL OF CONTROLLED RELEASE

The Efficacy of Probiotics, Prebiotic Inulin-Type Fructans, and Synbiotics in Human Ulcerative Colitis: A Systematic Review and Meta-Analysis

(2019) Erola Astó et al.   Nutrients

Probiotics, prebiotics, and low FODMAP diet for irritable bowel syndrome – What is the current evidence?

(2019) Soo Liang Ooi et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

(2018) Niranjan G. Kotla et al.   ADVANCED DRUG DELIVERY REVIEWS

Colon-targeted dexamethasone microcrystals with pH-sensitive chitosan/alginate/Eudragit S multilayers for the treatment of inflammatory bowel disease

(2018) Murtada A. Oshi et al.   CARBOHYDRATE POLYMERS

Starch film-coated microparticles for oral colon-specific drug delivery

(2018) Jin Chen et al.   CARBOHYDRATE POLYMERS

Current pharmaceutical strategies for efficient site specific delivery in inflamed distal intestinal mucosa

(2018) Sumit Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Species Level Description of the Human Ileal Bacterial Microbiota

(2018) Heidi Cecilie Villmones et al.   Scientific Reports

Prebiotics and Probiotics in Digestive Health

(2018) Eamonn M.M. Quigley   Clinical Gastroenterology and Hepatology

In vitro and in vivo evaluation of coated capsules for colonic delivery

(2018) Somayeh Handali et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review

(2018) Christina Pentafragka et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

In Vitro Ecological Response of the Human Gut Microbiome to Bioactive Extracts from Edible Wild Mushrooms

(2018) Emanuel Vamanu et al.   MOLECULES

The Use of a Mini-Bioreactor Fermentation System as a Reproducible, High-Throughput ex vivo Batch Model of the Distal Colon

(2018) Michelle M. O’Donnell et al.   Frontiers in Microbiology

Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery

(2018) Vicente Linares et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Probiotics in human health and disease: from nutribiotics to pharmabiotics

(2018) Eun-Sook Lee et al.   JOURNAL OF MICROBIOLOGY

Probiotics supplementation for the obesity management; A systematic review of animal studies and clinical trials

(2018) Hanieh-Sadat Ejtahed et al.   Journal of Functional Foods

A comparative study of the gut microbiota in immune-mediated inflammatory diseases—does a common dysbiosis exist?

(2018) Jessica D. Forbes et al.   Microbiome

Probiotic supplements might not be universally-effective and safe: A review

(2018) Damini Kothari et al.   BIOMEDICINE & PHARMACOTHERAPY

Enteric coatings for colonic drug delivery: state of the art

(2017) Alessandra Maroni et al.   Expert Opinion on Drug Delivery

Storage and digestion stability of encapsulated curcumin in emulsions based on starch granule Pickering stabilization

(2017) Ali Marefati et al.   FOOD HYDROCOLLOIDS

Multi-Stimuli Responsive Self-Assembled Nanostructures Useful for Colon Drug Delivery

(2017) Santosh Yadav et al.   IEEE TRANSACTIONS ON NANOBIOSCIENCE

Pectin-zinc-chitosan-polyethylene glycol colloidal nano-suspension as a food grade carrier for colon targeted delivery of resveratrol

(2017) Hashem Andishmand et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation

(2017) Cornelius C. Dodoo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

(2017) Sufeng Zhang et al.   Nano Today

A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein

(2017) Bowen Jiang et al.   PHARMACEUTICAL RESEARCH

The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides

(2017) Alfonso Benítez-Páez et al.   Frontiers in Cellular and Infection Microbiology

Pan-Colonic Pressurizations Associated With Relaxation of the Anal Sphincter in Health and Disease: A New Colonic Motor Pattern Identified Using High-Resolution Manometry

(2016) Maura Corsetti et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Calcium pectinate gel beads obtained from callus cultures pectins as promising systems for colon-targeted drug delivery

(2016) Elena A. Günter et al.   CARBOHYDRATE POLYMERS

Soluble curcumin amalgamated chitosan microspheres augmented drug delivery and cytotoxicity in colon cancer cells: In vitro and in vivo study

(2016) Kiran Jyoti et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dissolution profile of theophylline modified release tablets, using a biorelevant Dynamic Colon Model (DCM)

(2016) Konstantinos Stamatopoulos et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The harmonized INFOGEST in vitro digestion method: From knowledge to action

(2016) Lotti Egger et al.   FOOD RESEARCH INTERNATIONAL

A novel dissolution media for testing drug release from a nanostructured polysaccharide-based colon specific drug delivery system: an approach to alternative colon media

(2016) Thomas Webster et al.   International Journal of Nanomedicine

Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms

(2016) Miriam Verwei et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Colon targeted oral drug delivery system based on alginate-chitosan microspheres loaded with icariin in the treatment of ulcerative colitis

(2016) Qiang-Song Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Erodible drug delivery systems for time-controlled release into the gastrointestinal tract

(2016) Alessandra Maroni et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery

(2016) Lin Hou et al.   NANOTECHNOLOGY

Insight to drug delivery aspects for colorectal cancer

(2016) Arvind Gulbake   WORLD JOURNAL OF GASTROENTEROLOGY

Carboxymethyl starch/alginate microspheres containing diamine oxidase for intestinal targeting

(2015) Lindsay Blemur et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

(2015) Petia Kovatcheva-Datchary et al.   Cell Metabolism

Preparation and Evaluation of Newly Developed Chitosan Salt Coating Dispersions for Colon Delivery without Requiring Overcoating

(2015) Kyohei Yamada et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

In vitro–in vivocorrelations: general concepts, methodologies and regulatory applications

(2015) Ignacio González-García et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

(2015) Sachin Kumar Singh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In-vitro simulation of luminal conditions for evaluation of performance of oral drug products: Choosing the appropriate test media

(2015) Constantinos Markopoulos et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

(2015) Bart Claeys et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap® System

(2015) Mirko Koziolek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

(2015) Susan Hua et al.   Nanomedicine-Nanotechnology Biology and Medicine

Characterization of Contents of Distal Ileum and Cecum to Which Drugs/Drug Products are Exposed During Bioavailability/Bioequivalence Studies in Healthy Adults

(2015) Christos Reppas et al.   PHARMACEUTICAL RESEARCH

Quantification ofin vivocolonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry

(2014) P. G. Dinning et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

A standardised static in vitro digestion method suitable for food – an international consensus

(2014) M. Minekus et al.   Food & Function

Experimental models of the gut microbiome

(2013) Koen Venema et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

(2013) Philip Carsten Christophersen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

(2013) Christel A.S. Bergström et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In vitro models for the prediction of in vivo performance of oral dosage forms

(2013) Edmund S. Kostewicz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria,in vitro

(2013) Karen P. Scott et al.   FEMS MICROBIOLOGY ECOLOGY

Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota

(2013) Zhigang Zhang et al.   ISME Journal

Enzyme Sensitive Synthetic Polymer Micelles Based on the Azobenzene Motif

(2013) Jingyi Rao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Fate of curcumin encapsulated in silica nanoparticle stabilized Pickering emulsion during storage and simulated digestion

(2012) Rohan V. Tikekar et al.   FOOD RESEARCH INTERNATIONAL

Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon

(2012) Xiaolei Ze et al.   ISME Journal

Biorelevant in-vitro performance testing of orally administered dosage forms

(2012) Christos Reppas et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Blueberry Husks and Probiotics Attenuate Colorectal Inflammation and Oncogenesis, and Liver Injuries in Rats Exposed to Cycling DSS-Treatment

(2012) Åsa Håkansson et al.   PLoS One

Cultured Representatives of Two Major Phylogroups of Human Colonic Faecalibacterium prausnitzii Can Utilize Pectin, Uronic Acids, and Host-Derived Substrates for Growth

(2011) Mireia Lopez-Siles et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effects on weight gain and gut microbiota in rats given bacterial supplements and a high-energy-dense diet from fetal life through to 6 months of age

(2011) Caroline L. J. Karlsson et al.   BRITISH JOURNAL OF NUTRITION

In vitro–in vivo correlation: Perspectives on model development

(2011) Ying Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel microbially triggered colon specific delivery system of 5-Fluorouracil: Statistical optimization, in vitro, in vivo, cytotoxic and stability assessment

(2011) Rakesh Kumar Dev et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Flow Behavior of Digesta and the Absorption of Nutrients in the Gastrointestine

(2011) Toru TAKAHASHI   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Barcoded Pyrosequencing Reveals That Consumption of Galactooligosaccharides Results in a Highly Specific Bifidogenic Response in Humans

(2011) Lauren M. G. Davis et al.   PLoS One

Development of oral food-grade delivery systems: Current knowledge and future challenges

(2011) Revital Cohen Benshitrit et al.   Food & Function

Gut Microbiota and Inflammation

(2011) Asa Hakansson et al.   Nutrients

Functional metagenomics to mine the human gut microbiome for dietary fiber catabolic enzymes

(2010) L. Tasse et al.   GENOME RESEARCH

Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon

(2010) Daniel Aguirre de Cárcer et al.   ISME Journal

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

Mass Transfer and Nutrient Absorption in a Simulated Model of Small Intestine

(2010) A. Tharakan et al.   JOURNAL OF FOOD SCIENCE

A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach

(2010) Fanbin Kong et al.   JOURNAL OF FOOD SCIENCE

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery systems for liquid food products

(2009) Laurent Sagalowicz et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Towards the human intestinal microbiota phylogenetic core

(2009) Julien Tap et al.   ENVIRONMENTAL MICROBIOLOGY

Novel polymeric film coatings for colon targeting: Drug release from coated pellets

(2009) Youness Karrout et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Starch-based coatings for colon-specific delivery. Part II: Physicochemical properties and in vitro drug release from high amylose maize starch films

(2009) C. Freire et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

(2009) Petra Louis et al.   FEMS MICROBIOLOGY LETTERS

Preparation and evaluation of an oral delivery system for time-dependent colon release of insulin and selected protease inhibitor and absorption enhancer compounds

(2009) Maria Dorly Del Curto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Metronidazole loaded pectin microspheres for colon targeting

(2009) Ankur vaidya et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

More than 9,000,000 Unique Genes in Human Gut Bacterial Community: Estimating Gene Numbers Inside a Human Body

(2009) Xing Yang et al.   PLoS One

Linking phylogenetic identities of bacteria to starch fermentation in anin vitromodel of the large intestine by RNA-based stable isotope probing

(2008) Petia Kovatcheva-Datchary et al.   ENVIRONMENTAL MICROBIOLOGY

Carboxymethyl high amylose starch: Chitosan self-stabilized matrix for probiotic colon delivery

(2008) Carmen Calinescu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

MMX mesalamine: a novel high-dose, once-daily 5-aminosalicylate formulation for the treatment of ulcerative colitis

(2008) Mary Y Hu et al.   EXPERT OPINION ON PHARMACOTHERAPY

Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch

(2008) Guy C.J. Abell et al.   FEMS MICROBIOLOGY ECOLOGY

Physical characteristics of digesta and their influence on flow and mixing in the mammalian intestine: a review

(2008) R. G. Lentle et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man

(2008) Emma L. McConnell et al.   JOURNAL OF CONTROLLED RELEASE

Microbiota-triggered colonic delivery: Robustness of the polysaccharide approach in the fed state in man

(2008) Abdul W. Basit et al.   JOURNAL OF DRUG TARGETING

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH

Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora

(2007) Libo Yang   JOURNAL OF CONTROLLED RELEASE