Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease

(2021) Marcin Woźniak et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Specific arterio-venous transcriptomic and ncRNA-RNA interactions in human umbilical endothelial cells: A meta-analysis

(2021) Fabian Vega-Tapia et al.   iScience

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure

(2020) Monia Marchetti   ANNALS OF HEMATOLOGY

MiR-21-5p directly contributes to regulating eNOS expression in human artery endothelial cells under normoxia and hypoxia

(2020) Estefania Peñaloza et al.   BIOCHEMICAL PHARMACOLOGY

Changes in Endothelial Nitric Oxide Production in Systemic Vessels during Early Ontogenesis—A Key Mechanism for the Perinatal Adaptation of the Circulatory System

(2019) Dina Gaynullina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Primary endothelial–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia

(2019) Rafal Bartoszewski et al.   FASEB JOURNAL

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

(2019) Najah Albadari et al.   Expert Opinion on Drug Discovery

Hypoxia signaling in human diseases and therapeutic targets

(2019) Jae W. Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hypoxia Enhances Endothelial Intercellular Adhesion Molecule 1 Protein Level Through Upregulation of Arginase Type II and Mitochondrial Oxidative Stress

(2019) Xiujie Liang et al.   Frontiers in Physiology

Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression

(2019) Saxena et al.   Biomolecules

Senescence Marker Protein 30 Deficiency Exacerbates Pulmonary Hypertension in Hypoxia-Exposed Mice

(2019) Koichi Sugimoto et al.   International Heart Journal

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer.

(2018) Imre Hunyor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

(2018) Marcin Serocki et al.   ANGIOGENESIS

eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells

(2018) Anna Janaszak-Jasiecka et al.   ANGIOGENESIS

Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary EndotheliumHighlights

(2018) Deepesh Pandey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arginase: A Multifaceted Enzyme Important in Health and Disease

(2018) R. William Caldwell et al.   PHYSIOLOGICAL REVIEWS

Hypoxia driven glycation: Mechanisms and therapeutic opportunities

(2018) Mohammad Imran Khan et al.   SEMINARS IN CANCER BIOLOGY

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

(2017) Andrea Iorga et al.   Biology of Sex Differences

Angiogenesis in the atherosclerotic plaque

(2017) Caroline Camaré et al.   Redox Biology

Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia

(2016) José López-Barneo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension

(2016) Sudakshina Ghosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs

(2016) Anna Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vascular endothelium – Gatekeeper of vessel health

(2016) Paul A. Cahill et al.   ATHEROSCLEROSIS

Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs

(2016) Leszek Kalinowski et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

HIF2α–arginase axis is essential for the development of pulmonary hypertension

(2016) Andrew S. Cowburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Induced NF-κB

(2016) Laura D’Ignazio et al.   Cells

Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase

(2015) Karel Chalupsky et al.   ANTIOXIDANTS & REDOX SIGNALING

Concentraciones de proteínas de estrés térmico, L-arginina y dimetilarginina asimétrica en pacientes con síndrome de apnea obstructiva del sueño

(2015) Erdal İn et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Intermittent Hypoxemia and OSA

(2015) Naresh A. Dewan et al.   CHEST

HIF3α: the little we know

(2015) Linda Ravenna et al.   FEBS Journal

Vascular nitric oxide: Beyond eNOS

(2015) Yingzi Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

(2015) Lin Wang et al.   MICROVASCULAR RESEARCH

Roles of miRNA-24 in regulating endothelial nitric oxide synthase expression and vascular endothelial cell proliferation

(2015) Wenyu Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Asymmetric Dimethyl-l-Arginine is a Biomarker for Disease Stage and Follow-Up of Pulmonary Hypertension Associated with Congenital Heart Disease

(2015) Zhen-fei Fang et al.   PEDIATRIC CARDIOLOGY

Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha

(2015) Michaela Pekarova et al.   VASCULAR PHARMACOLOGY

Concentraciones de proteínas de estrés térmico, L-arginina y dimetilarginina asimétrica en pacientes con síndrome de apnea obstructiva del sueño

(2015) Erdal İn et al.   ARCHIVOS DE BRONCONEUMOLOGIA

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia

(2014) Lucio Iannone et al.   BIOCHEMICAL JOURNAL

Molecular Mechanisms of Endothelial NO Synthase Uncoupling

(2014) Suxin Luo et al.   CURRENT PHARMACEUTICAL DESIGN

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

Acute hypoxia produces a superoxide burst in cells

(2014) Pablo Hernansanz-Agustín et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

The Endothelial ADMA/NO Pathway in Hypoxia-Related Chronic Respiratory Diseases

(2014) Nicole Lüneburg et al.   Biomed Research International

Nitric Oxide Deficiency in Pulmonary Hypertension: Pathobiology and Implications for Therapy

(2014) Adriano R. Tonelli et al.   Pulmonary Circulation

Effects of Tetrahydrobiopterin Oral Treatment in Hypoxia-Induced Pulmonary Hypertension in Rat

(2014) Bahaa N. Francis et al.   Pulmonary Circulation

Tetrahydrobiopterin: biochemistry and pathophysiology

(2013) Ernst R. Werner et al.   BIOCHEMICAL JOURNAL

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

(2013) John Pernow et al.   CARDIOVASCULAR RESEARCH

Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Epigenetic Changes in the eNOS Gene

(2013) Leila Kheirandish-Gozal et al.   CHEST

Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses

(2013) Bernardo J Krause et al.   Epigenetics

Active Stabilization of Human Endothelial Nitric Oxide Synthase mRNA by hnRNP E1 Protects against Antisense RNA and MicroRNAs

(2013) J. J. D. Ho et al.   MOLECULAR AND CELLULAR BIOLOGY

NF- B inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF- B in immune-mediated diseases

(2013) B. Sehnert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

(2013) Jin Qian et al.   Frontiers in Physiology

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation

(2013) Zhihong Yang et al.   Frontiers in Immunology

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase

(2012) Hai-Xiang Sun et al.   HYPERTENSION

Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1)

(2012) Joachim Strobel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chronic hypoxia inhibits tetrahydrobiopterin-induced NO production in rat lungs

(2012) Karel Koubský et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Chronic intermittent hypoxia down-regulates endothelial nitric oxide synthase expression by an NF-κB-dependent mechanism

(2012) Baoshan Wang et al.   SLEEP MEDICINE

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

(2011) S Chandra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells

(2011) Hongmei Cui et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

MicroRNA changes in human arterial endothelial cells with senescence: Relation to apoptosis, eNOS and inflammation

(2011) Catarina Rippe et al.   EXPERIMENTAL GERONTOLOGY

RAGE mediates vascular injury and inflammation after global cerebral ischemia

(2011) Tomoya Kamide et al.   NEUROCHEMISTRY INTERNATIONAL

Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium

(2011) C.P. Prieto et al.   PLACENTA

Hypoxic upregulation of arginase II in human lung endothelial cells

(2010) Karina Krotova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

eNOS phosphorylation in health and disease

(2010) Gopi Krishna Kolluru et al.   BIOCHIMIE

What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology

(2010) Bradford G. Hill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat

(2010) Xue-Feng Xu et al.   JOURNAL OF HYPERTENSION

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Hormonal modulation of endothelial NO production

(2010) Sue P. Duckles et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells

(2009) Barbara Olszewska-Pazdrak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

The role of hypoxia in atherosclerosis

(2009) Lillemor Mattsson Hultén et al.   CURRENT OPINION IN LIPIDOLOGY

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis

(2009) C. Antoniades et al.   EUROPEAN HEART JOURNAL

Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation

(2009) J. F. Garvey et al.   EUROPEAN RESPIRATORY JOURNAL

Tetrahydrobiopterin Recycling, a Key Determinant of Endothelial Nitric-oxide Synthase-dependent Signaling Pathways in Cultured Vascular Endothelial Cells

(2009) Toru Sugiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones

(2009) Jason E. Fish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues

(2009) J.-L. Balligand et al.   PHYSIOLOGICAL REVIEWS

Obstructive Sleep Apnea and Pulmonary Hypertension

(2009) Dimitar Sajkov et al.   PROGRESS IN CARDIOVASCULAR DISEASES

eNOS, metabolic syndrome and cardiovascular disease

(2009) Paul L. Huang   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammation, Oxidative Stress, and Repair Capacity of the Vascular Endothelium in Obstructive Sleep Apnea

(2008) Sanja Jelic et al.   CIRCULATION

Oxygen Deprivation Triggers Upregulation of Early Growth Response-1 by the Receptor for Advanced Glycation End Products

(2008) Jong Sun Chang et al.   CIRCULATION RESEARCH

ROLE OF l-ARGININE IN NITRIC OXIDE PRODUCTION IN HEALTH AND HYPERTENSION

(2008) Niwanthi W Rajapakse et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCɛ signaling axis in pulmonary artery smooth muscle cells

(2008) R RATHORE et al.   FREE RADICAL BIOLOGY AND MEDICINE

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure

(2008) Shuangxi Wang et al.   HYPERTENSION

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

(2008) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Role of HSP90 Complexes with Endothelial Nitric-oxide Synthase (eNOS) and Calpain on Nitric Oxide Generation in Endothelial Cells

(2008) Monica Averna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis

(2008) Judith C. Sluimer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypoxia-Inducible Factor-1α and -2α Additively Promote Endothelial Vasculogenic Properties

(2008) Jeremy Ben-Shoshan et al.   JOURNAL OF VASCULAR RESEARCH