Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression

Obstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma Cells

(2019) Chloe-Anne Martinez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of cycling hypoxia on MCF-7 cancer stem cells and the impact of their microenvironment on angiogenesis using human umbilical vein endothelial cells (HUVECs) as a model

(2019) Fuad M. Alhawarat et al.   PeerJ

Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment

(2019) Xuefei Li et al.   Frontiers in Oncology

Translating the Hypoxic Response—the Role of HIF Protein Translation in the Cellular Response to Low Oxygen

(2019) Iglika G. Ivanova et al.   Cells

Primary endothelial–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia

(2019) Rafal Bartoszewski et al.   FASEB JOURNAL

Chronic intermittent hypoxia enhances disease progression in myeloma-resistant mice

(2019) Mahmoud Ali et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Volumetric optoacoustic imaging unveils high-resolution patterns of acute and cyclic hypoxia in a murine model of breast cancer

(2019) Avihai Ron et al.   CANCER RESEARCH

Intratumoral Heterogeneity: More Than Just Mutations

(2019) Kunihiko Hinohara et al.   TRENDS IN CELL BIOLOGY

Intermittent hypoxia alleviates increased VEGF and pro‑angiogenic potential in liver cancer cells

(2019) Gang Dong et al.   Oncology Letters

Acute and chronic hypoxia differentially predispose lungs for metastases

(2019) Moritz Reiterer et al.   Scientific Reports

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer.

(2018) Imre Hunyor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

(2018) Marcin Serocki et al.   ANGIOGENESIS

Imaging of oxygen and hypoxia in cell and tissue samples

(2018) Dmitri B. Papkovsky et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression

(2018) Carolina Cubillos-Zapata et al.   MEDIATORS OF INFLAMMATION

Intermittent hypoxia induces a metastatic phenotype in breast cancer

(2018) Anna Chen et al.   ONCOGENE

Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC)

(2018) Young Kwang Chae et al.   Scientific Reports

Physiological and Biological Responses to Short-Term Intermittent Hypobaric Hypoxia Exposure: From Sports and Mountain Medicine to New Biomedical Applications

(2018) Ginés Viscor et al.   Frontiers in Physiology

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

(2018) Muhammad Zaeem Noman et al.   OncoImmunology

Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity

(2018) Mohit Kumar Jolly et al.   Frontiers in Oncology

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

(2018) Julian Hlouschek et al.   Frontiers in Oncology

Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia

(2018) Julian Hlouschek et al.   CANCER LETTERS

The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies

(2018) Joaquín Araos et al.   CLINICAL & EXPERIMENTAL METASTASIS

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

(2018) Mohit Kumar Jolly et al.   PHARMACOLOGY & THERAPEUTICS

The Different Routes to Metastasis via Hypoxia-Regulated Programs

(2018) Ana Rita Nobre et al.   TRENDS IN CELL BIOLOGY

The role of the hypoxia-Nrp-1 axis in the activation of M2-like tumor-associated macrophages in the tumor microenvironment of cervical cancer

(2018) Xiao-Jing Chen et al.   MOLECULAR CARCINOGENESIS

Microfluidic device to attain high spatial and temporal control of oxygen

(2018) Sandra F. Lam et al.   PLoS One

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

(2018) Federico Bocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

(2018) Toni Celià-Terrassa et al.   Nature Communications

miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia

(2018) Kinga Kochan-Jamrozy et al.   CELLULAR SIGNALLING

Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea

(2017) Carolina Cubillos-Zapata et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice

(2017) Teresa Gallego-Martin et al.   EUROPEAN RESPIRATORY JOURNAL

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

EMT and MET: necessary or permissive for metastasis?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea

(2017) Antoni Vilaseca et al.   PLoS One

Intermittent hypoxia and cancer: Undesirable bed partners?

(2017) Isaac Almendros et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Hypoxia‑inducible factor 1 mediates intermittent hypoxia‑induced migration of human breast cancer MDA‑MB‑231 cells

(2017) Litao Liu et al.   Oncology Letters

Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea

(2017) Noelia Campillo et al.   Scientific Reports

Hypoxia-inducible factor 3 biology: complexities and emerging themes

(2016) Cunming Duan   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia

(2016) Johann Matschke et al.   ANTIOXIDANTS & REDOX SIGNALING

Cycling hypoxia: A key feature of the tumor microenvironment

(2016) Carine Michiels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells

(2016) Katrin Gutsche et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distinctive properties of metastasis-initiating cells

(2016) Toni Celià-Terrassa et al.   GENES & DEVELOPMENT

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

(2016) Satyendra C. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea

(2016) Mahzad Akbarpour et al.   SLEEP

Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of P18 through claudin7

(2016) Hong Liu et al.   Oncotarget

p53 in the DNA-Damage-Repair Process

(2016) Ashley B. Williams et al.   Cold Spring Harbor Perspectives in Medicine

Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

(2016) Nadia Gildeh et al.   Journal of Thoracic Disease

Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea

(2016) Mahzad Akbarpour et al.   SLEEP

miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells

(2016) Anna Janaszak-Jasiecka et al.   Scientific Reports

Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia

(2016) Andrew Dhawan et al.   Scientific Reports

Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment

(2015) Isaac Almendros et al.   CANCER LETTERS

Intermittent Hypoxemia and OSA

(2015) Naresh A. Dewan et al.   CHEST

Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme

(2015) Wei-Ling Chen et al.   Journal of Translational Medicine

Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision

(2015) Marcelo Boareto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity

(2015) Gadintshware Gaoatswe et al.   SLEEP

Obstructive sleep apnea promotes cancer development and progression: a concise review

(2015) Jie Cao et al.   Sleep and Breathing

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

(2015) Isabel R. Schlaepfer et al.   Oncotarget

Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis

(2015) Bin Huang et al.   Scientific Reports

Cycling Hypoxia Induces a Specific Amplified Inflammatory Phenotype in Endothelial Cells and Enhances Tumor-Promoting Inflammation In Vivo

(2015) Céline Tellier et al.   NEOPLASIA

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Progress toward overcoming hypoxia-induced resistance to solid tumor therapy

(2015) Mauricio Reginato et al.   Cancer Management and Research

Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity

(2015) Gadintshware Gaoatswe et al.   SLEEP

Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance

(2015) Daniel Verduzco et al.   PLoS One

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia

(2015) Miguel A. S. Cavadas et al.   Scientific Reports

Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea

(2014) Isaac Almendros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia

(2014) Miguel A. Acosta et al.   Biomicrofluidics

Mechanisms of Hypoxia-Mediated Immune Escape in Cancer

(2014) I. B. Barsoum et al.   CANCER RESEARCH

Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia

(2014) James Bagnall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems

(2014) Joseph Leedale et al.   MATHEMATICAL BIOSCIENCES

Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia

(2014) HAITAO ZHU et al.   ONCOLOGY REPORTS

Apoptotic Cell Death Under Hypoxia

(2014) Ataman Sendoel et al.   PHYSIOLOGY

Influence of different hypoxia models on metastatic potential of SGC-7901 gastric cancer cells

(2014) Zhi-Feng Miao et al.   TUMOR BIOLOGY

Sleep apnea awakens cancer

(2014) David Gozal et al.   OncoImmunology

Hypoxia-inducible factor (HIF) network: insights from mathematical models

(2013) Miguel AS Cavadas et al.   Cell Communication and Signaling

HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells

(2013) ZHENFENG GUAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Dynamic equilibrium between cancer stem cells and non-stem cancer cells in human SW620 and MCF-7 cancer cell populations

(2012) G Yang et al.   BRITISH JOURNAL OF CANCER

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoea

(2012) I. Almendros et al.   EUROPEAN RESPIRATORY JOURNAL

NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme

(2012) Chia-Hung Hsieh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumors exposed to acute cyclic hypoxia show increased vessel density and delayed blood supply

(2012) Jon-Vidar Gaustad et al.   MICROVASCULAR RESEARCH

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

(2012) Chii-Wen Chou et al.   NEURO-ONCOLOGY

Intermittent Hypoxia Regulates Stem-like Characteristics and Differentiation of Neuroblastoma Cells

(2012) Vasantha Kumar Bhaskara et al.   PLoS One

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Impact of Hypoxia on the Metastatic Potential of Human Prostate Cancer Cells

(2011) Yao Dai et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1  and 2 

(2011) Q. Lin et al.   MOLECULAR CANCER RESEARCH

Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG–EGFR/ErbB4 autocrine loop

(2011) D P Stiehl et al.   ONCOGENE

Imaging Cycling Tumor Hypoxia

(2010) S. Matsumoto et al.   CANCER RESEARCH

HIF-1α signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells

(2010) Viktor Malec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination

(2010) Einar K. Rofstad et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of chronic intermittent hypoxia on biological behavior and hypoxia-associated gene expression in lung cancer cells

(2010) Yonglei Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

(2010) Hsieh   ONCOLOGY REPORTS

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

Intermittent hypoxia is an angiogenic inducer for endothelial cells: role of HIF-1

(2009) Sébastien Toffoli et al.   ANGIOGENESIS

The humanHIF(hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction

(2009) Tetsuhiro Tanaka et al.   BIOCHEMICAL JOURNAL

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Hypoxia and Radiation Therapy: Past History, Ongoing Research, and Future Promise

(2009) Sara Rockwell et al.   CURRENT MOLECULAR MEDICINE

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intermittent hypoxia degrades HIF-2  via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities

(2009) J. Nanduri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive oxygen species and HIF-1 signalling in cancer

(2008) Alex Galanis et al.   CANCER LETTERS

The Pervasive Presence of Fluctuating Oxygenation in Tumors

(2008) L. I. Cardenas-Navia et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Impact of cyclic hypoxia on HIF-1α regulation in endothelial cells - new insights for anti-tumor treatments

(2008) Philippe Martinive et al.   FEBS Journal

Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

(2008) S. Toffoli et al.   FEBS Journal

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY