Tetrahydrobiopterin: biochemistry and pathophysiology

Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection

(2010) Irina A. Ionova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

(2010) Gad A. Silberman et al.   CIRCULATION

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice

(2010) Tim S. Schmidt et al.   CLINICAL SCIENCE

An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning

(2010) Toshihito Hiroi et al.   EXPERIMENTAL PHYSIOLOGY

Tetrahydrobiopterin protects the kidney from ischemia–reperfusion injury

(2010) Robert Sucher et al.   KIDNEY INTERNATIONAL

Phenylketonuria

(2010) Nenad Blau et al.   LANCET

Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: A plausible gateway for the salvage pathway of Tetrahydrobiopterin biosynthesis

(2010) Akiko Ohashi et al.   MOLECULAR GENETICS AND METABOLISM

Molecular genetics and impact of residual in vitro phenylalanine hydroxylase activity on tetrahydrobiopterin responsiveness in Turkish PKU population

(2010) Steven F. Dobrowolski et al.   MOLECULAR GENETICS AND METABOLISM

Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life

(2010) Claudia Kriegebaum et al.   NEUROCHEMISTRY INTERNATIONAL

Tetrahydrobiopterin as a novel therapeutic intervention for autism

(2010) Richard E. Frye et al.   Neurotherapeutics

Nitric oxide and oxidative stress in vascular disease

(2010) Ulrich Förstermann   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes

(2010) K. Watschinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Nitric Oxide Synthase and Human Vascular Regulation

(2010) Narbeh Melikian et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes

(2009) Lu Tie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats

(2009) Jianzhong An et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Plasma Tetrahydrobiopterin/Dihydrobiopterin Ratio

(2009) Masafumi Takeda et al.   CIRCULATION JOURNAL

GTP Cyclohydrolase I Phosphorylation and Interaction With GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide

(2009) Li Li et al.   CIRCULATION RESEARCH

Targeting Redox Signaling in the Vascular Wall: From Basic Science to Clinical Practice

(2009) Charalambos Antoniades et al.   CURRENT PHARMACEUTICAL DESIGN

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I

(2009) S. Wang et al.   DIABETES

Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: Convergent data from Tph2 knockout mice

(2009) Lise Gutknecht et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Examination of tetrahydrobiopterin pathway genes in autism

(2009) N. C. Schnetz-Boutaud et al.   GENES BRAIN AND BEHAVIOR

GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression

(2009) Amy L. Tatham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desaturases: Emerging Models for Understanding Functional Diversification of Diiron-containing Enzymes

(2009) John Shanklin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrahydrobiopterin Recycling, a Key Determinant of Endothelial Nitric-oxide Synthase-dependent Signaling Pathways in Cultured Vascular Endothelial Cells

(2009) Toru Sugiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium

(2009) V. V. Shuvaev et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PROSITE, a protein domain database for functional characterization and annotation

(2009) Christian J. A. Sigrist et al.   NUCLEIC ACIDS RESEARCH

Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels

(2009) Chang-Kwon Lee et al.   PROTEOMICS

Nitric Oxide, Tetrahydrobiopterin, Oxidative Stress, and Endothelial Dysfunction in Hypertension

(2008) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

l-Arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease

(2008) M. Settergren et al.   ATHEROSCLEROSIS

Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence

(2008) Katrin Watschinger et al.   BIOLOGICAL CHEMISTRY

Endothelium-Specific GTP Cyclohydrolase I Overexpression Attenuates Blood Pressure Progression in Salt-Sensitive Low-Renin Hypertension

(2008) Yan-Hua Du et al.   CIRCULATION

Effects of tetrahydrobiopterin on venous bubble grade and acute diving-induced changes in cardiovascular function

(2008) Duska Glavas et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype

(2008) Irmgard Tegeder et al.   EUROPEAN JOURNAL OF PAIN

Mutations in human monoamine-related neurotransmitter pathway genes

(2008) Jan Haavik et al.   HUMAN MUTATION

Direct Binding of GTP Cyclohydrolase and Tyrosine Hydroxylase

(2008) Kevin M. Bowling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrahydrobiopterin: a novel antihypertensive therapy

(2008) M Porkert et al.   JOURNAL OF HUMAN HYPERTENSION

The phenotypic spectrum of paediatric neurotransmitter diseases and infantile parkinsonism

(2008) R. Pons   JOURNAL OF INHERITED METABOLIC DISEASE

Tetrahydrobiopterin in intestinal lumen: Its absorption and secretion in the small intestine and the elimination in the large intestine

(2008) K. Sawabe et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Transcellular relocation of tetrahydrobiopterin across Caco-2 cells: A model study of tetrahydrobiopterin absorption through epithelial cells of intestinal mucosa

(2008) A. Ohashi et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium

(2008) Carsten Wunderlich et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice

(2008) Lise Gutknecht et al.   JOURNAL OF NEURAL TRANSMISSION

Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase

(2008) Beat Thny et al.   JOURNAL OF NEUROCHEMISTRY

Cellular uptake of sepiapterin and push–pull accumulation of tetrahydrobiopterin

(2008) Keiko Sawabe et al.   MOLECULAR GENETICS AND METABOLISM

Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia

(2008) K. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects

(2008) Zvonimir S. Katusic et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production

(2008) Manasi Nandi et al.   VASCULAR MEDICINE

Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency

(2007) Leandra Jäggi et al.   MOLECULAR GENETICS AND METABOLISM