HIF2α–arginase axis is essential for the development of pulmonary hypertension

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE

(2016) Zhiyu Dai et al.   CIRCULATION

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice

(2016) Pinelopi P. Kapitsinou et al.   MOLECULAR AND CELLULAR BIOLOGY

Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs

(2015) Hartmut Grasemann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hepatic Shunting of Eggs and Pulmonary Vascular Remodeling inBmpr2+/−Mice with Schistosomiasis

(2015) Alexi Crosby et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia

(2015) YanBiao Chu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood

(2015) Mark L. Ormiston et al.   Jove-Journal of Visualized Experiments

Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

(2014) D. Macias et al.   EMBO Molecular Medicine

Transcript Analysis Reveals a Specific HOX Signature Associated with Positional Identity of Human Endothelial Cells

(2014) Mark Toshner et al.   PLoS One

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1  to promote cell-cycle progression

(2014) M. E. Hubbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of disturbed blood flow in the development of pulmonary arterial hypertension: lessons from preclinical animal models

(2013) Michael G. Dickinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

(2013) Molly K. Ball et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease

(2013) J.-W. Wang et al.   BLOOD

HIF isoforms in the skin differentially regulate systemic arterial pressure

(2013) A. S. Cowburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

(2012) Cristina Branco-Price et al.   CANCER CELL

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Measuring exhaled nitric oxide in animal models: methods and clinical implications

(2012) Nhât-Nam Le-Dong et al.   Journal of Breath Research

Praziquantel Reverses Pulmonary Hypertension and Vascular Remodeling in Murine Schistosomiasis

(2011) Alexi Crosby et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension

(2010) Amy L. Firth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Regulation of human metabolism by hypoxia-inducible factor

(2010) Federico Formenti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia response pathway in border cell migration

(2010) Inna Djagaeva et al.   Cell Adhesion & Migration

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension

(2009) Mark Toshner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Vascular Remodeling Correlates with Lung Eggs and Cytokines in Murine Schistosomiasis

(2009) Alexi Crosby et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Vascularization by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   Annals of the New York Academy of Sciences

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

(2007) S. O. Park et al.   BLOOD