Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs

Rescue Treatment with L-Citrulline Inhibits Hypoxia-Induced Pulmonary Hypertension in Newborn Pigs

(2015) Candice D. Fike et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase

(2015) Karel Chalupsky et al.   ANTIOXIDANTS & REDOX SIGNALING

Sapropterin Is Safe and Effective in Patients less than 4-Years-Old with BH4-Responsive Phenylalanine Hydroxylase Deficiency

(2014) Haruo Shintaku et al.   JOURNAL OF PEDIATRICS

Sodium-Coupled Neutral Amino Acid Transporter 1 (SNAT1) Modulates L-Citrulline Transport and Nitric Oxide (NO) Signaling in Piglet Pulmonary Arterial Endothelial Cells

(2014) Anna Dikalova et al.   PLoS One

Effects of Tetrahydrobiopterin Oral Treatment in Hypoxia-Induced Pulmonary Hypertension in Rat

(2014) Bahaa N. Francis et al.   Pulmonary Circulation

Nitric Oxide Deficiency and Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2013) James R. Klinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tetrahydrobiopterin in Cardiovascular Health and Disease

(2013) Jennifer K. Bendall et al.   ANTIOXIDANTS & REDOX SIGNALING

Pulmonary vascular disease in bronchopulmonary dysplasia

(2013) Peter M. Mourani et al.   CURRENT OPINION IN PEDIATRICS

Long-term Follow-up and Outcome of Phenylketonuria Patients on Sapropterin: A Retrospective Study

(2013) S. Keil et al.   PEDIATRICS

Reactive Oxygen Species-Reducing Strategies Improve Pulmonary Arterial Responses to Nitric Oxide in Piglets with Chronic Hypoxia-Induced Pulmonary Hypertension

(2012) Candice D. Fike et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen and nitrogen species in pulmonary hypertension

(2012) Diana M. Tabima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Efficacy and safety of BH4 before the age of 4 years in patients with mild phenylketonuria

(2012) Oriane Leuret et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities

(2011) Rinrada Kietadisorn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure

(2011) An L. Moens et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

(2010) Anna E. Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Potential therapeutic applications of tetrahydrobiopterin: from inherited hyperphenylalaninemia to mitochondrial diseases

(2010) Hyoung K. Kim et al.   Annals of the New York Academy of Sciences

Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-κB in human aortic smooth muscle cells

(2010) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Safety of sapropterin dihydrochloride (6r–bh4) in patients with pulmonary hypertension

(2010) Ivan M. Robbins et al.   EXPERIMENTAL LUNG RESEARCH

Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders

(2010) Jan F. Gielis et al.   FREE RADICAL BIOLOGY AND MEDICINE

l-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets

(2009) Madhumita Ananthakrishnan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets

(2009) Kathleen E. Dennis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS

(2008) Mark J. Crabtree et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pharmacokinetics of Sapropterin in Patients with Phenylketonuria

(2008) François Feillet et al.   CLINICAL PHARMACOKINETICS

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

(2008) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrahydrobiopterin: a novel antihypertensive therapy

(2008) M Porkert et al.   JOURNAL OF HUMAN HYPERTENSION

Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects

(2008) Zvonimir S. Katusic et al.   TRENDS IN PHARMACOLOGICAL SCIENCES