miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target
Authors
Keywords
microRNAs, HIFs, Hypoxia, Target protectors, Morpholinos
Journal
ANGIOGENESIS
Volume 21, Issue 2, Pages 183-202
Publisher
Springer Nature
Online
2018-01-27
DOI
10.1007/s10456-018-9600-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells
- (2017) Rafal Bartoszewski et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
- (2017) Mircea Ivan et al. MOLECULAR CELL
- Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial–mesenchymal transition by regulating HIF-1α via miR-138
- (2017) Qiang Cai et al. Open Biology
- SNPs in microRNA target sites and their potential role in human disease
- (2017) Adrianna Moszyńska et al. Open Biology
- Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro
- (2016) Tessa D. Nauta et al. ANGIOGENESIS
- A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α
- (2016) Fan Wang et al. CANCER BIOLOGY & THERAPY
- A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
- (2016) Eli M. Wallace et al. CANCER RESEARCH
- Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs
- (2016) Leszek Kalinowski et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE
- (2016) Zhiyu Dai et al. CIRCULATION
- Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma
- (2016) Alan Ka-Lun Kai et al. HEPATOLOGY
- Exosomal transfer of miR-30a between cardiomyocytes regulates autophagy after hypoxia
- (2016) Yan Yang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- MicroRNA-433 Inhibits the Proliferation and Migration of HUVECs and Neurons by Targeting Hypoxia-Inducible Factor 1 Alpha
- (2016) Lin Zhang et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- MicroRNA-103/107 is involved in hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by targeting HIF-1β
- (2016) Bi Deng et al. LIFE SCIENCES
- MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia
- (2016) Youbang Xie et al. Molecular Medicine Reports
- Overexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3α in osteoarthritis
- (2016) ZHIFU LI et al. Molecular Medicine Reports
- Long noncoding RNAs in kidney and cardiovascular diseases
- (2016) Johan M. Lorenzen et al. Nature Reviews Nephrology
- Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes
- (2016) Xiuchao Wang et al. Oncotarget
- microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5′-untranslated region in neuroblastoma
- (2016) Hongxia Qu et al. Oncotarget
- MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer
- (2016) Xiaoxiao Ge et al. Oncotarget
- MicroRNA-206 attenuates the growth and angiogenesis in non-small cell lung cancer cells by blocking the 14-3-3ζ/STAT3/HIF-1α/VEGF signaling
- (2016) Dong Xue et al. Oncotarget
- Role of Mir-155 in Controlling HIF-1α Level and Promoting Endothelial Cell Maturation
- (2016) Deguang Yang et al. Scientific Reports
- MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma
- (2016) Alessia Lo Dico et al. Theranostics
- Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
- (2016) Javier Rodriguez et al. Cell Reports
- miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation
- (2016) Tianji Chen et al. Journal of the American Heart Association
- Correction: HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells
- (2016) Tessa D. Nauta et al. PLoS One
- miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells
- (2016) Anna Janaszak-Jasiecka et al. Scientific Reports
- Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis
- (2015) C Blick et al. BRITISH JOURNAL OF CANCER
- Hypoxia promotes apoptosis of neuronal cells through hypoxia-inducible factor-1α-microRNA-204-B-cell lymphoma-2 pathway
- (2015) Xiuwen Wang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop
- (2015) Sylwia Bartoszewska et al. FASEB JOURNAL
- HIF3α: the little we know
- (2015) Linda Ravenna et al. FEBS Journal
- Hypoxia-inducible factor-3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene
- (2015) Satomi Kobayashi et al. GENES TO CELLS
- Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy
- (2015) I. Spinello et al. HAEMATOLOGICA
- Endothelial Hypoxia-Inducible Factor-1α Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a
- (2015) Shamima Akhtar et al. HYPERTENSION
- Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia
- (2015) Ikki Tsuboi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury
- (2015) K. Bhatt et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
- (2015) Patrick H. Maxwell et al. Nature Reviews Nephrology
- The role of hypoxia-inducible factor-2 in digestive system cancers
- (2015) J Zhao et al. Cell Death & Disease
- microRNA-18a regulates gastric carcinoma cell apoptosis and invasion by suppressing hypoxia-inducible factor-1α expression
- (2015) FUBING WU et al. Experimental and Therapeutic Medicine
- HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGFβ-signaling in hypoxic microenvironment.
- (2015) Neha Nagpal et al. Scientific Reports
- Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy
- (2015) I. Spinello et al. HAEMATOLOGICA
- MicroRNA-18a Decreases Choroidal Endothelial Cell Proliferation and Migration by Inhibiting HIF1A Expression
- (2015) Wei Jiang MEDICAL SCIENCE MONITOR
- Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
- (2014) T. Umezu et al. BLOOD
- A feedback regulatory loop between HIF-1α and miR-21 in response to hypoxia in cardiomyocytes
- (2014) Yang Liu et al. FEBS LETTERS
- Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness
- (2014) Giuseppina Raspaglio et al. GENE
- Modulation of hypoxia-signaling pathways by extracellular linc-RoR
- (2014) K. Takahashi et al. JOURNAL OF CELL SCIENCE
- Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
- (2014) Carme Camps et al. Molecular Cancer
- MicroRNA-382 induced by HIF-1α is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog
- (2014) Jin-Kyung Seok et al. NUCLEIC ACIDS RESEARCH
- Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression
- (2014) Rajesha Rupaimoole et al. Nature Communications
- Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
- (2014) Twan van den Beucken et al. Nature Communications
- Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia
- (2014) Peng Zhang et al. Cell Reports
- HypoxamiR Regulation and Function in Ischemic Cardiovascular Diseases
- (2013) Simona Greco et al. ANTIOXIDANTS & REDOX SIGNALING
- Transcriptional regulation by hypoxia inducible factors
- (2013) Veronica L. Dengler et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect
- (2013) Fan Yang et al. MOLECULAR CELL
- Regulation of the Hif-system by micro-RNA 17 and 20a – Role during monocyte-to-macrophage differentiation
- (2013) David M. Poitz et al. MOLECULAR IMMUNOLOGY
- RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts
- (2013) Sarah Geisler et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- HIF-1 is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2 -induced excessive erythropoiesis
- (2012) K. Franke et al. BLOOD
- HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation
- (2012) M He et al. CELL DEATH AND DIFFERENTIATION
- Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
- (2012) Yan Xia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Functional Importance of Dicer Protein in the Adaptive Cellular Response to Hypoxia
- (2012) J. J. David Ho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells
- (2012) Shih-Chieh Lin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha
- (2012) H Zhang et al. ONCOGENE
- MicroRNA 107 Partly Inhibits Endothelial Progenitor Cells Differentiation via HIF-1β
- (2012) Shu Meng et al. PLoS One
- Hypoxia-Induced Alternative Splicing in Endothelial Cells
- (2012) Julia E. Weigand et al. PLoS One
- Acute versus chronic hypoxia in tumors
- (2012) C. Bayer et al. STRAHLENTHERAPIE UND ONKOLOGIE
- Passing the baton: the HIF switch
- (2012) Mei Yee Koh et al. TRENDS IN BIOCHEMICAL SCIENCES
- HIF-1 versus HIF-2 — Is one more important than the other?
- (2012) Agnieszka Loboda et al. VASCULAR PHARMACOLOGY
- The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
- (2011) M. Y. Koh et al. CANCER RESEARCH
- Characterization of novel antisense HIF-1α transcripts in human cancers
- (2011) Davide Bertozzi et al. CELL CYCLE
- Upregulation of MicroRNA-210 Regulates Renal Angiogenesis Mediated by Activation of VEGF Signaling Pathway under Ischemia/Perfusion Injury in vivo and in vitro
- (2011) Fen Liu et al. KIDNEY & BLOOD PRESSURE RESEARCH
- MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1 Activity during Prolonged Hypoxia
- (2011) U. Bruning et al. MOLECULAR AND CELLULAR BIOLOGY
- Use of target protector morpholinos to analyze the physiological roles of specific miRNA-mRNA pairs in vivo
- (2011) Alison A Staton et al. Nature Protocols
- Dynamic mechanisms for pre-miRNA binding and export by Exportin-5
- (2011) X. Wang et al. RNA
- MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT
- (2010) Zhan Zhang et al. CELL CYCLE
- MicroRNA-210: A unique and pleiotropic hypoxamir
- (2010) Stephen Y. Chan et al. CELL CYCLE
- The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
- (2010) Na Zhang et al. Cell Metabolism
- Hypoxia-inducible factor (HIF)-3α is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2
- (2010) Annika Pasanen et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells
- (2010) Yuk Cheung Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis
- (2010) Goutam Ghosh et al. JOURNAL OF CLINICAL INVESTIGATION
- Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing
- (2010) Chanseok Shin et al. MOLECULAR CELL
- Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
- (2010) Ji-Hong Lim et al. MOLECULAR CELL
- Hypoxia-Inducible Factors and the Response to Hypoxic Stress
- (2010) Amar J. Majmundar et al. MOLECULAR CELL
- microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age
- (2010) Nicole Noren Hooten et al. PLoS One
- P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
- (2010) M. Yamakuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MicroRNA sponges: Progress and possibilities
- (2010) M. S. Ebert et al. RNA
- A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
- (2010) D. Cifuentes et al. SCIENCE
- MicroRNAs Induced During Ischemic Preconditioning
- (2010) Soon-Tae Lee et al. STROKE
- Endothelial deletion of hypoxia-inducible factor-2 (HIF-2 ) alters vascular function and tumor angiogenesis
- (2009) N. Skuli et al. BLOOD
- MicroRNAs: Target Recognition and Regulatory Functions
- (2009) David P. Bartel CELL
- Kruppel-like Factor 2 Inhibits Hypoxia-inducible Factor 1α Expression and Function in the Endothelium
- (2009) Daiji Kawanami et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
- (2009) David R. Mole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
- (2009) Weibo Luo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation
- (2009) Xin Huang et al. MOLECULAR CELL
- Many roads to maturity: microRNA biogenesis pathways and their regulation
- (2009) Julia Winter et al. NATURE CELL BIOLOGY
- Generating specificity and diversity in the transcriptional response to hypoxia
- (2009) Urban Lendahl et al. NATURE REVIEWS GENETICS
- Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration
- (2009) Zhang Lei et al. PLoS One
- HIF-1 attenuates Ref-1 expression in endothelial cells: Reversal by siRNA and inhibition of geranylgeranylation
- (2009) Agnieszka Loboda et al. VASCULAR PHARMACOLOGY
- Biology of HIF-1α
- (2008) A Weidemann et al. CELL DEATH AND DIFFERENTIATION
- Biology of hypoxia-inducible factor-2α in development and disease
- (2008) S A Patel et al. CELL DEATH AND DIFFERENTIATION
- hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
- (2008) C. Camps et al. CLINICAL CANCER RESEARCH
- MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3
- (2008) Pasquale Fasanaro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now