Arginase: A Multifaceted Enzyme Important in Health and Disease

Intravascular hemolysis and the pathophysiology of sickle cell disease

(2017) Gregory J. Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1–Deficient Thoracic Cancers

(2017) Emma Beddowes et al.   JOURNAL OF CLINICAL ONCOLOGY

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1–Dependent Uncoupling of Endothelial Nitric Oxide Synthase

(2017) Nuria Villalba et al.   JOURNAL OF NEUROTRAUMA

Is the Urea Cycle Involved in Alzheimer's Disease?

(2017) Franck Hansmannel et al.   JOURNAL OF ALZHEIMERS DISEASE

Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2016) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice

(2016) Jochen Steppan et al.   ANESTHESIA AND ANALGESIA

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

(2016) C. Patel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease

(2016) Andrew D. Greenhalgh et al.   BRAIN BEHAVIOR AND IMMUNITY

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

Amino acid metabolism reflecting arginase activity is increased in patients with type 2 diabetes and associated with endothelial dysfunction

(2016) Oskar Kövamees et al.   Diabetes & Vascular Disease Research

Treatment effect of l-Norvaline on the sexual performance of male rats with streptozotocin induced diabetes

(2016) Abhijit De et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular basis and current strategies of therapeutic arginine depletion for cancer

(2016) Livingstone Fultang et al.   INTERNATIONAL JOURNAL OF CANCER

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

(2016) Anil Bhatta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

(2016) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Molecular mechanisms associated with diabetic endothelial–erectile dysfunction

(2016) Ângela Castela et al.   Nature Reviews Urology

Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia

(2016) Akihiro Watanabe et al.   NEUROSCIENCE

HIF2α–arginase axis is essential for the development of pulmonary hypertension

(2016) Andrew S. Cowburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

(2016) Esraa Shosha et al.   Cell Death & Disease

T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

(2016) Patrick L. Raber et al.   Oncotarget

The role of the arginine metabolome in pain: implications for sickle cell disease

(2016) Claudia Morris et al.   Journal of Pain Research

Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs

(2015) Hartmut Grasemann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vasculopathy and pulmonary hypertension in sickle cell disease

(2015) Karin P. Potoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese MiceSignificance

(2015) Ning Xia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arginase inhibition ameliorates adipose tissue inflammation in mice with diet-induced obesity

(2015) Huan Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy

(2015) Mushfiquddin Khan et al.   BMC NEUROSCIENCE

FoxO4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1Novelty and Significance

(2015) Min Zhu et al.   CIRCULATION RESEARCH

Angiotensin II limits NO production by upregulating arginase through a p38 MAPK–ATF-2 pathway

(2015) Alia Shatanawi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

(2015) P.S. Garry et al.   EXPERIMENTAL NEUROLOGY

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis

(2015) Leticia Monin et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells

(2015) Cong Ye et al.   JOURNAL OF IMMUNOLOGY

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation

(2015) Jonathan D. Cherry et al.   Journal of Neuroinflammation

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy

(2015) J. B. Hunt et al.   JOURNAL OF NEUROSCIENCE

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

(2015) Lin Wang et al.   MICROVASCULAR RESEARCH

Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia

(2015) YanBiao Chu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Arginase inhibition protects against hypoxia-induced pulmonary arterial hypertension

(2015) WENJIN JIANG et al.   Molecular Medicine Reports

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction

(2015) Riccardo Lacchini et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity

(2015) Ashley B. Petrone et al.   Translational Stroke Research

Angiotensin II-Induced Arterial Thickening, Fibrosis and Stiffening Involves Elevated Arginase Function

(2015) Anil Bhatta et al.   PLoS One

Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2

(2014) D. Pandey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Eflornithine (DFMO) Prevents Progression of Pancreatic Cancer by Modulating Ornithine Decarboxylase Signaling

(2014) A. Mohammed et al.   Cancer Prevention Research

L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

(2014) M. Fletcher et al.   CANCER RESEARCH

OxLDL Triggers Retrograde Translocation of Arginase2 in Aortic Endothelial Cells via ROCK and Mitochondrial Processing Peptidase

(2014) Deepesh Pandey et al.   CIRCULATION RESEARCH

Increased arginase levels contribute to impaired perfusion after cardiopulmonary resuscitation

(2014) Christian Jung et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

New approaches to the design and discovery of therapies to prevent erectile dysfunction

(2014) Haroldo A Toque et al.   Expert Opinion on Drug Discovery

Alterations of the Arginine Metabolome in Sickle Cell Disease

(2014) Claudia R. Morris   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

The function of spermine

(2014) Anthony E. Pegg   IUBMB LIFE

Extracellular Signal-regulated Kinase Mediates Expression of Arginase II but Not Inducible Nitric-oxide Synthase in Lipopolysaccharide-stimulated Macrophages

(2014) Yi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cecropia pachystachya extract attenuated the renal lesion in 5/6 nephrectomized rats by reducing inflammation and renal arginase activity

(2014) Claudia C. Maquiaveli et al.   JOURNAL OF ETHNOPHARMACOLOGY

Altered arginine metabolism in Alzheimer's disease brains

(2014) Ping Liu et al.   NEUROBIOLOGY OF AGING

The Importance of Nitric Oxide and Arginase in the Pathogenesis of Acute Neuroinflammation: Are Those Contra Players with the Same Direction?

(2014) Srdjan Ljubisavljevic et al.   NEUROTOXICITY RESEARCH

Effect of Arginase Inhibition on Ischemia-Reperfusion Injury in Patients with Coronary Artery Disease with and without Diabetes Mellitus

(2014) Oskar Kövamees et al.   PLoS One

Arginase 2 Deficiency Prevents Oxidative Stress and Limits Hyperoxia-Induced Retinal Vascular Degeneration

(2014) Jutamas Suwanpradid et al.   PLoS One

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

(2014) S P Narayanan et al.   Cell Death & Disease

Macrophage: SHIP of Immunity

(2014) Charles D. Mills et al.   Frontiers in Immunology

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

(2014) Zhihong Yang et al.   Frontiers in Immunology

Arginase in the Vascular Endothelium: Friend or Foe?

(2014) Rudolf Lucas et al.   Frontiers in Immunology

Evolutionary Roots of Arginase Expression and Regulation

(2014) Jolanta Maria Dzik   Frontiers in Immunology

“Of Mice and Men”: Arginine Metabolism in Macrophages

(2014) Anita C. Thomas et al.   Frontiers in Immunology

Arginase inhibition improves coronary microvascular function and reduces infarct size following ischaemia-reperfusion in a rat model

(2013) J. Grönros et al.   Acta Physiologica

Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS

(2013) Shawn Elms et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

(2013) John Pernow et al.   CARDIOVASCULAR RESEARCH

Traumatic brain injury induces macrophage subsets in the brain

(2013) Christine L. Hsieh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effect of stroke on arginase expression and localization in the rat brain

(2013) Aurore Quirié et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Arginase as a target for treatment of myocardial ischemia-reperfusion injury

(2013) Yahor Tratsiakovich et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impaired L-Arginine Uptake But Not Arginase Contributes to Endothelial Dysfunction in Rats With Chronic Kidney Disease

(2013) Christopher R. Martens et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Shaping the Murine Macrophage Phenotype: IL-4 and Cyclic AMP Synergistically Activate the Arginase I Promoter

(2013) K. E. Sheldon et al.   JOURNAL OF IMMUNOLOGY

Activated Rho Kinase Mediates Diabetes‐Induced Elevation of Vascular Arginase Activation and Contributes to Impaired Corpora Cavernosa Relaxation: Possible Involvement of p38 MAPK Activation

(2013) Haroldo A. Toque et al.   Journal of Sexual Medicine

Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism

(2013) Hanning You et al.   KIDNEY INTERNATIONAL

Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability

(2013) Yuyan Xiong et al.   Journal of the American Heart Association

Selective Up-Regulation of Arginase-1 in Coronary Arteries of Diabetic Patients

(2013) Zsolt Bagi et al.   Frontiers in Immunology

Role of Arginase in Vessel Wall Remodeling

(2013) William Durante   Frontiers in Immunology

Arginase 1 Mediates Increased Blood Pressure and Contributes to Vascular Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertension

(2013) Haroldo A. Toque et al.   Frontiers in Immunology

Arginase as a mediator of diabetic retinopathy

(2013) Chintan Patel   Frontiers in Immunology

l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice

(2013) Maritza J. Romero et al.   Frontiers in Immunology

Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction

(2013) Jochen Steppan et al.   Frontiers in Immunology

IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension

(2012) Won-Kyung Cho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

(2012) Joseph E. Qualls et al.   Cell Host & Microbe

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

(2012) S. C. Elms et al.   DIABETOLOGIA

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma

(2012) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Chronic Oral Administration of the Arginase Inhibitor 2(S)-amino-6-boronohexanoic Acid (ABH) Improves Erectile Function in Aged Rats

(2012) R. Segal et al.   JOURNAL OF ANDROLOGY

Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis

(2012) Srdjan Ljubisavljevic et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia

(2012) K Morrow et al.   LEUKEMIA

Glomerular hyperfiltration: a marker of early renal damage in pre-diabetes and pre-hypertension

(2012) P. Palatini   NEPHROLOGY DIALYSIS TRANSPLANTATION

Ganglion Cell Loss in Relation to Visual Disability in Multiple Sclerosis

(2012) Scott D. Walter et al.   OPHTHALMOLOGY

The Polyamine Inhibitor Alpha-Difluoromethylornithine Modulates Hippocampus-Dependent Function after Single and Combined Injuries

(2012) Susanna Rosi et al.   PLoS One

Regression of Atherosclerosis Is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

(2012) Jonathan E. Feig et al.   PLoS One

Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production

(2012) Adrian T. Gonon et al.   PLoS One

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

(2011) Alia Shatanawi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Arginase inhibition restores in vivo coronary microvascular function in type 2 diabetic rats

(2011) Julia Grönros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes

(2011) Timea Beleznai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diabetes-induced vascular dysfunction involves arginase I

(2011) Maritza J. Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intracellular l-arginine concentration does not determine NO production in endothelial cells: Implications on the “l-arginine paradox”

(2011) Soyoung Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

(2011) M P Kelly et al.   BRITISH JOURNAL OF CANCER

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

(2011) S Chandra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arginase-2 Mediates Diabetic Renal Injury

(2011) Sidney M. Morris et al.   DIABETES

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Vision in Multiple Sclerosis

(2011) Reiko E. Sakai et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Arginase 2 Deletion Reduces Neuro-Glial Injury and Improves Retinal Function in a Model of Retinopathy of Prematurity

(2011) Subhadra P. Narayanan et al.   PLoS One

Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism

(2011) John A. Watts et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Hypoxic upregulation of arginase II in human lung endothelial cells

(2010) Karina Krotova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia

(2010) Yi Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling

(2010) Sungwoo Ryoo et al.   ATHEROSCLEROSIS

Pegylated arginase I: a potential therapeutic approach in T-ALL

(2010) C. P. Hernandez et al.   BLOOD

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

(2010) Joris D Veltman et al.   BMC CANCER

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

(2010) Teddy Bagnost et al.   CARDIOVASCULAR RESEARCH

Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB

(2010) Vera Barra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeted Inhibition of Inducible Nitric Oxide Synthase Inhibits Growth of Human Melanoma In vivo and Synergizes with Chemotherapy

(2010) A. G. Sikora et al.   CLINICAL CANCER RESEARCH

Impact of Arginase II on CBF in Experimental Cortical Impact Injury in Mice Using MRI

(2010) Brittany R Bitner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

L-Arginine Deprivation Regulates Cyclin D3 mRNA Stability in Human T Cells by Controlling HuR Expression

(2010) P. C. Rodriguez et al.   JOURNAL OF IMMUNOLOGY

A Large-Scale Chemical Screen for Regulators of the Arginase 1 Promoter Identifies the Soy Isoflavone Daidzeinas a Clinically Approved Small Molecule That Can Promote Neuronal Protection or Regeneration via a cAMP-Independent Pathway

(2010) T. C. Ma et al.   JOURNAL OF NEUROSCIENCE

Arginase II Deletion Increases Corpora Cavernosa Relaxation in Diabetic Mice

(2010) Haroldo A. Toque et al.   Journal of Sexual Medicine

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Arginase Activity Mediates Retinal Inflammation in Endotoxin-Induced Uveitis

(2009) Wenbo Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

(2009) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Paradoxical effect of l-arginine: Acceleration of endothelial cell senescence

(2009) Fortunato Scalera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries

(2009) NN Huynh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Recent advances in arginine metabolism: roles and regulation of the arginases

(2009) Sidney M Morris Jr   BRITISH JOURNAL OF PHARMACOLOGY

Arginase inhibition mediates cardioprotection during ischaemia-reperfusion

(2009) C. Jung et al.   CARDIOVASCULAR RESEARCH

Discovery of the nitric oxide signaling pathway and targets for drug development

(2009) Nathan et al.   Frontiers in Bioscience-Landmark

Arginase II Knockout Mouse Displays a Hypertensive Phenotype Despite a Decreased Vasoconstrictory Profile

(2009) Ngan N. Huynh et al.   HYPERTENSION

Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats

(2009) Teddy Bagnost et al.   HYPERTENSION RESEARCH

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

(2009) Jae Hyung Kim et al.   JOURNAL OF APPLIED PHYSIOLOGY

Increased Synthesis of Spermidine as a Result of Upregulation of Arginase I Promotes Axonal Regeneration in Culture and In Vivo

(2009) K. Deng et al.   JOURNAL OF NEUROSCIENCE

Polyamine Catabolism Is Enhanced after Traumatic Brain Injury

(2009) Kamyar Zahedi et al.   JOURNAL OF NEUROTRAUMA

Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances

(2009) N. Toda et al.   PHARMACOLOGICAL REVIEWS

Endothelial Arginase II

(2008) Sungwoo Ryoo et al.   CIRCULATION RESEARCH

Contrasting features of urea cycle disorders in human patients and knockout mouse models

(2008) Joshua L. Deignan et al.   MOLECULAR GENETICS AND METABOLISM

Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects

(2008) Zvonimir S. Katusic et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

(2007) Maritza J. Romero et al.   CIRCULATION RESEARCH