Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

(2012) Lin Yao et al.   CARDIOVASCULAR RESEARCH

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

(2012) S. C. Elms et al.   DIABETOLOGIA

Plasma asymmetric dimethylarginine and mortality in patients with acute decompensation of chronic heart failure

(2012) Michael N Zairis et al.   HEART

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

(2012) Jérôme Badaut et al.   Journal of Neuroinflammation

Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production

(2012) Adrian T. Gonon et al.   PLoS One

Diabetes-induced vascular dysfunction involves arginase I

(2011) Maritza J. Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arginase I Attenuates Inflammatory Cytokine Secretion Induced by Lipopolysaccharide in Vascular Smooth Muscle Cells

(2011) Xu-ping Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

(2011) S Chandra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term

(2011) Chenming Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impacts of Lisinopril and Lisinopril Plus Simvastatin on Erythrocyte and Plasma Arginase, Nitrite, and Nitrate in Hypertensive Patients

(2011) Elena Kosenko et al.   JOURNAL OF CLINICAL PHARMACOLOGY

S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase

(2011) Jessilyn Dunn et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium

(2011) C.P. Prieto et al.   PLACENTA

Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism

(2011) John A. Watts et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism

(2011) John A. Watts et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Hypoxic upregulation of arginase II in human lung endothelial cells

(2010) Karina Krotova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation

(2010) Philipp Heusch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling

(2010) Sungwoo Ryoo et al.   ATHEROSCLEROSIS

Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling

(2010) B. S. Zuckerbraun et al.   CARDIOVASCULAR RESEARCH

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

(2010) Teddy Bagnost et al.   CARDIOVASCULAR RESEARCH

Association of serum arginase I with oxidative stress in a healthy population

(2010) Keiki Ogino et al.   FREE RADICAL RESEARCH

Impact of Arginase II on CBF in Experimental Cortical Impact Injury in Mice Using MRI

(2010) Brittany R Bitner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

p38 Mitogen-Activated Protein Kinase (MAPK) Increases Arginase Activity and Contributes to Endothelial Dysfunction in Corpora Cavernosa from Angiotensin-II-Treated Mice

(2010) Haroldo A. Toque et al.   Journal of Sexual Medicine

Arginase II Deletion Increases Corpora Cavernosa Relaxation in Diabetic Mice

(2010) Haroldo A. Toque et al.   Journal of Sexual Medicine

Oxidized Low-Density Lipoprotein Inhibits Nitric Oxide-Mediated Coronary Arteriolar Dilation by Up-regulating Endothelial Arginase I

(2010) WEI WANG et al.   MICROCIRCULATION

Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling

(2010) T. L. Barr et al.   NEUROLOGY

Modulating the NO generating system from a medicinal chemistry perspective: Current trends and therapeutic options in cardiovascular disease

(2010) Dennis Schade et al.   PHARMACOLOGY & THERAPEUTICS

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Arginase Activities and Global Arginine Bioavailability in Wild-Type and ApoE-Deficient Mice: Responses to High Fat and High Cholesterol Diets

(2010) Aaron Erdely et al.   PLoS One

Arginase Activity Mediates Retinal Inflammation in Endotoxin-Induced Uveitis

(2009) Wenbo Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

(2009) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries

(2009) Kelly J. Peyton et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of arginase pathway in response to wall shear stress

(2009) Tyler N. Thacher et al.   ATHEROSCLEROSIS

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia

(2009) Sowndramalingam Sankaralingam et al.   CARDIOVASCULAR RESEARCH

Arginase inhibition mediates cardioprotection during ischaemia-reperfusion

(2009) C. Jung et al.   CARDIOVASCULAR RESEARCH

Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model

(2009) Milan C. Richir et al.   CRITICAL CARE MEDICINE

Arginase II Knockout Mouse Displays a Hypertensive Phenotype Despite a Decreased Vasoconstrictory Profile

(2009) Ngan N. Huynh et al.   HYPERTENSION

Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats

(2009) Teddy Bagnost et al.   HYPERTENSION RESEARCH

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

(2009) Jae Hyung Kim et al.   JOURNAL OF APPLIED PHYSIOLOGY

Treatment with the arginase inhibitor Nω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat

(2009) Teddy Bagnost et al.   JOURNAL OF HYPERTENSION

Involvement of the ornithine decarboxylase/polyamine system in precondition-induced cardioprotection through an interaction with PKC in rat hearts

(2009) Ya-Jun Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Melatonin Ameliorates Cerebral Vasospasm After Experimental Subarachnoidal Haemorrhage Correcting Imbalance of Nitric Oxide Levels in Rats

(2009) M. A. Aladag et al.   NEUROCHEMICAL RESEARCH

Endothelial Arginase II

(2008) Sungwoo Ryoo et al.   CIRCULATION RESEARCH

Nitric Oxide and Arginine Dysregulation: A Novel Pathway to Pulmonary Hypertension in Hemolytic Disorders

(2008) Claudia Morris et al.   CURRENT MOLECULAR MEDICINE

Arginase and vascular aging

(2008) Lakshmi Santhanam et al.   JOURNAL OF APPLIED PHYSIOLOGY

Arginase I Induction by Modified Lipoproteins in Macrophages: A Peroxisome Proliferator-Activated Receptor-γ/δ-Mediated Effect that Links Lipid Metabolism and Immunity

(2008) Alejandro Gallardo-Soler et al.   MOLECULAR ENDOCRINOLOGY

L-arginine plasma levels and severity of idiopathic pulmonary arterial hypertension

(2008) Beyer et al.   Vasa-European Journal of Vascular Medicine

Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

(2007) Maritza J. Romero et al.   CIRCULATION RESEARCH