COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms

(2020) Wen Su et al.   Frontiers in Pharmacology

Mechanism of thrombocytopenia in COVID-19 patients

(2020) Panyang Xu et al.   ANNALS OF HEMATOLOGY

Upregulation of angiotensin converting enzyme 2 by shear stress reduced inflammation and proliferation in vascular endothelial cells

(2020) Jiantao Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effects of sepsis on endothelium and clinical implications

(2020) Elena V Dolmatova et al.   CARDIOVASCULAR RESEARCH

Exosome derived from CD137‐modified endothelial cells regulates the Th17 responses in atherosclerosis

(2020) Liangjie Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Macrophage stimulating 1-induced inflammation response promotes aortic aneurysm formation through triggering endothelial cells death and activating the NF-κB signaling pathway

(2020) Kai Lu et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2

(2020) Shiyu Yin et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants

(2020) Mohammad Afzal Khan et al.   Journal of Translational Medicine

Sirolimus and propranolol inhibit endothelial proliferation while detergent sclerosants induce endothelial activation, microparticle release and apoptosis in vitro

(2020) David E. Connor et al.   PHLEBOLOGY

Complement as a Major Inducer of Harmful Events in Infectious Sepsis

(2020) Fatemeh Fattahi et al.   SHOCK

Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome

(2020) Tania Romacho et al.   Scientific Reports

Recombinant adenosine deaminase ameliorates inflammation, vascular disease and fibrosis in preclinical models of systemic sclerosis

(2020) Yun Zhang et al.   Arthritis & Rheumatology

Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome

(2020) Gaurav Shrivastava et al.   Frontiers in Immunology

Hematological findings in coronavirus disease 2019: indications of progression of disease

(2020) Xiaoqing Liu et al.   ANNALS OF HEMATOLOGY

Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis

(2020) Giuseppe Lippi et al.   CLINICA CHIMICA ACTA

Mitochondrial superoxide mediates PM2.5-induced cytotoxicity in human pulmonary lymphatic endothelial cells

(2020) Ye Cui et al.   ENVIRONMENTAL POLLUTION

Epidemiology and clinical features of COVID-19: A review of current literature

(2020) Juan A. Siordia   JOURNAL OF CLINICAL VIROLOGY

The NADPH oxidase 4 protects vascular endothelial cells from copper oxide nanoparticles-induced oxidative stress and cell death

(2020) Hui He et al.   LIFE SCIENCES

CASIN and AMD3100 enhance endothelial cell proliferation, tube formation and sprouting

(2020) Batuhan Mert Kalkan et al.   MICROVASCULAR RESEARCH

Severe COVID-19 infection associated with endothelial activation

(2020) Robert Escher et al.   THROMBOSIS RESEARCH

Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

(2019) Yuting Jiang et al.   Viruses-Basel

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

(2019) Felix Carl Fabian Schmitt et al.   Annals of Intensive Care

Primary endothelial–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia

(2019) Rafal Bartoszewski et al.   FASEB JOURNAL

Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis

(2019) Gérard Socié et al.   BRITISH JOURNAL OF HAEMATOLOGY

Increase in circulating ACE-positive endothelial microparticles during acute lung injury

(2019) Yusuke Takei et al.   EUROPEAN RESPIRATORY JOURNAL

Unfractionated Heparin Alleviates Sepsis-Induced Acute Lung Injury by Protecting Tight Junctions

(2019) Yina Liu et al.   JOURNAL OF SURGICAL RESEARCH

Complement Components sC5b-9 and CH50 Predict Prognosis in Heart Failure Patients Combined With Hypertension

(2019) Wenyuan Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

The stimulation of thrombosis by hypoxia

(2019) Neha Gupta et al.   THROMBOSIS RESEARCH

IMPACT-TB*: A Phase II Trial Assessing the Capacity of Low Dose Imatinib to Induce Myelopoiesis and Enhance Host Anti-Microbial Immunity Against Tuberculosis. *Imatinib Mesylate per Oral As a Clinical Therapeutic for TB

(2019) Cynthia R. Giver et al.   BLOOD

Reduction of vascular leakage by imatinib is associated with preserved microcirculatory perfusion and reduced renal injury markers in a rat model of cardiopulmonary bypass

(2018) N.J. Koning et al.   BRITISH JOURNAL OF ANAESTHESIA

Deficiency of Complement C3a and C5a Receptors Prevents Angiotensin II–Induced Hypertension via Regulatory T CellsNovelty and Significance

(2018) Xiao-Hui Chen et al.   CIRCULATION RESEARCH

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

(2018) Jeanne M. Sisk et al.   JOURNAL OF GENERAL VIROLOGY

Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis

(2018) Thomas J. Bell et al.   MATRIX BIOLOGY

Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients

(2018) Yu-chang Wang et al.   MEDICINE

Role of complement C5a and histones in septic cardiomyopathy

(2018) Fatemeh Fattahi et al.   MOLECULAR IMMUNOLOGY

Vascular Effects of Adrenomedullin and the Anti-Adrenomedullin Antibody Adrecizumab in Sepsis

(2018) Christopher Geven et al.   SHOCK

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy

(2018) C. D. Barrett et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hypoxia-Inducible Factor (HIF)-1α Promotes Inflammation and Injury Following Aspiration-Induced Lung Injury in Mice

(2018) Madathilparambil V. Suresh et al.   SHOCK

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction

(2017) Fatemeh Fattahi et al.   FASEB JOURNAL

More than an anticoagulant: Do heparins have direct anti-inflammatory effects?

(2017) Timothy J. Poterucha et al.   THROMBOSIS AND HAEMOSTASIS

Coagulation and sepsis

(2017) Marcel Levi et al.   THROMBOSIS RESEARCH

Successful treatment of gemcitabine-induced acute interstitial pneumonia with imatinib mesylate: a case report

(2016) Elisabetta Fenocchio et al.   BMC CANCER

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion

(2016) Christopher M. Coleman et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

(2015) Jasper F. W. Chan et al.   CLINICAL MICROBIOLOGY REVIEWS

Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin

(2015) Norman F. Russkamp et al.   FASEB JOURNAL

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

(2015) Haixia Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial Immunity

(2015) Ruth J. Napier et al.   PLoS Pathogens

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Knockdown of Burton’s tyrosine kinase confers potent protection against sepsis-induced acute lung injury

(2014) Panyu Zhou et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment

(2014) Christine Veith et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

(2013) Shihui Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The role of the β2 adrenergic receptor on endothelial progenitor cells dysfunction of proliferation and migration in chronic obstructive pulmonary disease patients

(2013) Xiaoran Liu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Effective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib

(2012) Jurjan Aman et al.   CIRCULATION

Autotransplantation of circulating endothelial progenitor cells protects against lipopolysaccharide-induced acute lung injury in rabbit

(2011) Xiaofang Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Complete Resolution of Life-Threatening Bleomycin-Induced Pneumonitis After Treatment With Imatinib Mesylate in a Patient With Hodgkin's Lymphoma: Hope for Severe Chemotherapy-Induced Toxicity?

(2011) Fabrizio Carnevale-Schianca et al.   JOURNAL OF CLINICAL ONCOLOGY

Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza

(2011) Rieko Ohta et al.   MICROBIOLOGY AND IMMUNOLOGY

Possible role of imatinib in clinical pulmonary veno-occlusive disease

(2008) M. J. Overbeek et al.   EUROPEAN RESPIRATORY JOURNAL