Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations

Review of Design Considerations for Brain-on-a-Chip Models

(2021) Tiffany Cameron et al.   Micromachines

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms

(2020) Song Ih Ahn et al.   Nature Communications

3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

(2020) Aida Rodriguez-Garcia et al.   ADVANCES IN POLYMER TECHNOLOGY

Organ-on-a-chip engineering: Toward bridging the gap between lab and industry

(2020) Qasem Ramadan et al.   Biomicrofluidics

Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

(2020) Neda Azizipour et al.   Micromachines

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

(2020) Wandong Zhang et al.   Fluids and Barriers of the CNS

Mimicking Intravasation–Extravasation with a 3D Glass Nanofluidic Model for the Chemotaxis‐Free Migration of Cancer Cells in Confined Spaces

(2020) Felix Sima et al.   Advanced Materials Technologies

Picosecond Laser Processing of Photosensitive Glass for Generation of Biologically Relevant Microenvironments

(2020) Florin Jipa et al.   Applied Sciences-Basel

Brain-on-a-chip devices for drug screening and disease modeling applications

(2019) Beatrice Miccoli et al.   CURRENT PHARMACEUTICAL DESIGN

Emerging Role of Organ‐on‐a‐Chip Technologies in Quantitative Clinical Pharmacology Evaluation

(2019) Nina Isoherranen et al.   CTS-Clinical and Translational Science

On-Chip Anticancer Drug Screening – Recent Progress in Microfluidic Platforms to Address Challenges in Chemotherapy

(2019) Nandini Dhiman et al.   BIOSENSORS & BIOELECTRONICS

Advances in Microfluidic Blood–Brain Barrier (BBB) Models

(2019) Arianna Oddo et al.   TRENDS IN BIOTECHNOLOGY

Cell-Based Assays on Microfluidics for Drug Screening

(2019) Xiaoyan Liu et al.   ACS Sensors

Chipping Away at Blood-Brain-Barrier Modeling

(2019) John J. Jamieson et al.   Cell Stem Cell

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Engineering microsystems to recapitulate brain physiology on a chip

(2019) Kenneth Ndyabawe et al.   DRUG DISCOVERY TODAY

Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates

(2019) Icilio Cavero et al.   Expert Opinion On Drug Safety

Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders

(2019) Mirza Ali Mofazzal Jahromi et al.   MOLECULAR NEUROBIOLOGY

Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test

(2019) Yongjian Ai et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

Recent Progress in Microfluidic Models of the Blood-Brain Barrier

(2019) Lili Jiang et al.   Micromachines

A Reconfigurable In Vitro Model for Studying the Blood–Brain Barrier

(2019) Monica L. Moya et al.   ANNALS OF BIOMEDICAL ENGINEERING

Hybrid elastomer–plastic microfluidic device as a convenient model for mimicking the blood–brain barrier in vitro

(2019) Phuoc Quang Huy Nguyen et al.   BIOMEDICAL MICRODEVICES

An isogenic hiPSC-derived BBB-on-a-chip

(2019) Pedram Motallebnejad et al.   Biomicrofluidics

Long-term hydrophilization of polydimethylsiloxane (PDMS) for capillary filling microfluidic chips

(2019) Farzin Jahangiri et al.   Microfluidics and Nanofluidics

Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp

(2019) Stefan A. Mann et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Microfluidics: Innovations in Materials and Their Fabrication and Functionalization

(2019) Jacob B. Nielsen et al.   ANALYTICAL CHEMISTRY

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro

(2019) Somin Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies

(2018) Seiichi Ishida   Drug Metabolism and Pharmacokinetics

A Three-Dimensional Arrayed Microfluidic Blood–Brain Barrier Model With Integrated Electrical Sensor Array

(2018) Sehoon Jeong et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Construction of neurospheroids via surface modified concave microwells

(2018) GeonHui Lee et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Gliotransmission: Beyond Black-and-White

(2018) Iaroslav Savtchouk et al.   JOURNAL OF NEUROSCIENCE

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease

(2018) Mehdi Jorfi et al.   Scientific Reports

Simultaneous Assay of Oxygen-Dependent Cytotoxicity and Genotoxicity of Anticancer Drugs on an Integrated Microchip

(2018) Lili Li et al.   ANALYTICAL CHEMISTRY

Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system

(2018) Carlota Oleaga et al.   BIOMATERIALS

Improved microfluidic platform for simultaneous multiple drug screening towards personalized treatment

(2018) Oihane Mitxelena-Iribarren et al.   BIOSENSORS & BIOELECTRONICS

Go with the Flow-Microfluidics Approaches for Amyloid Research

(2018) Shai Zilberzwige-Tal et al.   Chemistry-An Asian Journal

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening

(2018) Youngmi Koo et al.   Scientific Reports

High Repetition Rate UV versus VIS Picosecond Laser Fabrication of 3D Microfluidic Channels Embedded in Photosensitive Glass

(2018) Florin Jipa et al.   Nanomaterials

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Microfluidics-Based Biomaterials and Biodevices

(2018) Ruihua Dong et al.   ADVANCED MATERIALS

3D organ models—Revolution in pharmacological research?

(2018) Marie Weinhart et al.   PHARMACOLOGICAL RESEARCH

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

(2017) Lorna Ewart et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Tissue chips – innovative tools for drug development and disease modeling

(2017) L. A. Low et al.   LAB ON A CHIP

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Ultrafast Laser Fabrication of Functional Biochips: New Avenues for Exploring 3D Micro- and Nano-Environments

(2017) Felix Sima et al.   Micromachines

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

(2017) Jannick Theobald et al.   ACS Biomaterials-Science & Engineering

In Vitro Intestinal and Liver Models for Toxicity Testing

(2017) Sophia M. Orbach et al.   ACS Biomaterials-Science & Engineering

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

(2017) Jannick Theobald et al.   ACS Biomaterials Science & Engineering

In Vitro Intestinal and Liver Models for Toxicity Testing

(2017) Sophia M. Orbach et al.   ACS Biomaterials Science & Engineering

Interplay between materials and microfluidics

(2017) Xu Hou et al.   Nature Reviews Materials

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium

(2017) Beatrice Mihaela Radu et al.   Scientific Reports

A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes

(2017) Seokyoung Bang et al.   Scientific Reports

Opportunities and challenges in developing relevant animal models for Alzheimer’s disease

(2016) Fernanda G. De Felice et al.   AGEING RESEARCH REVIEWS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

Shuttle-mediated nanoparticle transport across an in vitro brain endothelium under flow conditions

(2016) Andrea P. Falanga et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidics as a cutting-edge technique for drug delivery applications

(2016) Flavia Fontana et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

(2016) Jacquelyn A. Brown et al.   Journal of Neuroinflammation

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

(2016) Onur Kilic et al.   LAB ON A CHIP

Ultrafast laser ablation of soda-lime glass for fabricating microfluidic pillar array channels

(2016) Tien-Li Chang et al.   MICROELECTRONIC ENGINEERING

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier

(2016) Jack D. Wang et al.   MOLECULAR PHARMACEUTICS

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Microfabricated Physiological Models for In Vitro Drug Screening Applications

(2016) Giovanni Ugolini et al.   Micromachines

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors

(2016) Hui Xu et al.   Scientific Reports

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model

(2015) Katelyn L. Sellgren et al.   Biomicrofluidics

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Direct, one-step molding of 3D-printed structures for convenient fabrication of truly 3D PDMS microfluidic chips

(2015) Ho Nam Chan et al.   Microfluidics and Nanofluidics

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

A microfluidic four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) I. Maschmeyer et al.   TOXICOLOGY LETTERS

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

The neurovascular unit - concept review

(2014) V. Muoio et al.   Acta Physiologica

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

(2014) Joana Bicker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Hybrid femtosecond laser microfabrication to achieve true 3D glass/polymer composite biochips with multiscale features and high performance: the concept of ship-in-a-bottle biochip

(2014) Dong Wu et al.   Laser & Photonics Reviews

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Alpha synuclein is transported into and out of the brain by the blood–brain barrier

(2014) Yu-Ting Sui et al.   PEPTIDES

Cell-Culture Models of the Blood–Brain Barrier

(2014) Yarong He et al.   STROKE

Planar Microdevices for Enhanced In Vivo Retention and Oral Bioavailability of Poorly Permeable Drugs

(2014) Hariharasudhan D. Chirra et al.   Advanced Healthcare Materials

Ultrafast lasers—reliable tools for advanced materials processing

(2014) Koji Sugioka et al.   Light-Science & Applications

Materials for Microfluidic Chip Fabrication

(2013) Kangning Ren et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

(2013) Yu Liu et al.   ANNALS OF NEUROLOGY

β-Amyloid is transmitted via neuronal connections along axonal membranes

(2013) Ha-Lim Song et al.   ANNALS OF NEUROLOGY

Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons

(2013) Jiao Jiao et al.   HUMAN MOLECULAR GENETICS

Investigation of Rett syndrome using pluripotent stem cells

(2013) Rana Dajani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

(2013) Jocelyn F Krey et al.   NATURE NEUROSCIENCE

New players in the neurovascular unit: Insights from experimental and clinical epilepsy

(2013) Giuseppe Bertini et al.   NEUROCHEMISTRY INTERNATIONAL

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Neurovascular unit on a chip: implications for translational applications

(2013) Donald J Alcendor et al.   Stem Cell Research & Therapy

Rapid, simple, and cost-effective treatments to achieve long-term hydrophilic PDMS surfaces

(2012) Samu Hemmilä et al.   APPLIED SURFACE SCIENCE

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Femtosecond laser processing for optofluidic fabrication

(2012) Koji Sugioka et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells

(2012) Fei Yi et al.   Protein & Cell

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

3D microfluidic chips with integrated functional microelements fabricated by a femtosecond laser for studying the gliding mechanism of cyanobacteria

(2011) Yasutaka Hanada et al.   LAB ON A CHIP

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model

(2011) Gene Ananiev et al.   PLoS One

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

(2011) Steven D. Sheridan et al.   PLoS One

Surface modification of PDMS by atmospheric-pressure plasma-enhanced chemical vapor deposition and analysis of long-lasting surface hydrophilicity

(2011) Donghee Lee et al.   SENSORS AND ACTUATORS B-CHEMICAL

A neurospheroid network-stamping method for neural transplantation to the brain

(2010) Midori Kato-Negishi et al.   BIOMATERIALS

Oxygen plasma treatment for reducing hydrophobicity of a sealed polydimethylsiloxane microchannel

(2010) Say Hwa Tan et al.   Biomicrofluidics

Quantum dot based immunosensor using 3D circular microchannels fabricated in PDMS

(2010) Amit Morarka et al.   BIOSENSORS & BIOELECTRONICS

Sodium hydroxide treatment of PDMS based microfluidic devices

(2010) Ingrid Hoek et al.   LAB ON A CHIP

Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices

(2010) Kiana Aran et al.   LAB ON A CHIP

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Femtosecond laser-assisted etching of Pyrex glass with aqueous solution of KOH

(2009) Shigeki Matsuo et al.   APPLIED SURFACE SCIENCE

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Pharmacokinetic applications of microdevices and microsampling techniques

(2009) Florin Marcel Musteata   Bioanalysis

Translational Medicine: Science or Wishful Thinking?

(2008) Martin Wehling   Journal of Translational Medicine

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP