Emerging Role of Organ‐on‐a‐Chip Technologies in Quantitative Clinical Pharmacology Evaluation

Considerations for Developing Targeted Therapies in Low-Frequency Molecular Subsets of a Disease

(2018) Robert N. Schuck et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Kidney-on-a-Chip: A New Technology for Predicting Drug Efficacy, Interactions, and Drug-induced Nephrotoxicity

(2018) Jeonghwan Lee et al.   CURRENT DRUG METABOLISM

Maximizing the impact of microphysiological systems with in vitro–in vivo translation

(2018) Murat Cirit et al.   LAB ON A CHIP

3S - Systematic, systemic, and systems biology and toxicology

(2018) Lena Smirnova   ALTEX-Alternatives to Animal Experimentation

Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes

(2018) Young Bok Kang et al.   Scientific Reports

The International Transporter Consortium: Summarizing advances in the role of transporters in drug development

(2018) Kathleen M. Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

(2018) Yingying Guo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Commentary on fit-for-purpose models for regulatory applications

(2018) Yaning Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Role of Modeling and Simulation in the Development of Novel and Biosimilar Therapeutic Proteins

(2018) Yow-Ming C. Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Gastrointestinal microphysiological systems

(2017) Sarah E Blutt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Clinical Drug–Drug Interaction Evaluations to Inform Drug Use and Enable Drug Access

(2017) Dinko Rekić et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro – In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug–Drug Interactions—Overview of Basic Prediction Methods

(2017) Kenta Yoshida et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intestine-on-a-Chip Microfluidic Model for Efficient in Vitro Screening of Oral Chemotherapeutic Uptake

(2017) Kyall Pocock et al.   ACS Biomaterials-Science & Engineering

Intestine-on-a-Chip Microfluidic Model for Efficient in Vitro Screening of Oral Chemotherapeutic Uptake

(2017) Kyall Pocock et al.   ACS Biomaterials Science & Engineering

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

(2016) Daniel Scotcher et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

(2016) Jacquelyn A. Brown et al.   Journal of Neuroinflammation

Development of a microphysiological model of human kidney proximal tubule function

(2016) Elijah J. Weber et al.   KIDNEY INTERNATIONAL

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

(2014) Kristin M Fabre et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modeling and simulation of the exposure–response and dropout pattern of guanfacine extended-release in pediatric patients with ADHD

(2014) William Knebel et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

The Utility of Modeling and Simulation in Drug Development and Regulatory Review

(2013) Shiew-Mei Huang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Development of a placebo effect model combined with a dropout model for bipolar disorder

(2013) Wan Sun et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system

(2013) Edward J Kelly et al.   Stem Cell Research & Therapy

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

(2012) Leila Choucha-Snouber et al.   BIOTECHNOLOGY AND BIOENGINEERING

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

(2012) Amir R. Aref et al.   Integrative Biology

Quantification of disease progression and dropout for Alzheimer’s disease

(2012) Demiana William-Faltaos et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device

(2012) Dan Gao et al.   LAB ON A CHIP

Metabolomics-on-a-Chip of Hepatotoxicity Induced by Anticancer Drug Flutamide and Its Active Metabolite Hydroxyflutamide Using HepG2/C3a Microfluidic Biochips

(2012) Leila Choucha Snouber et al.   TOXICOLOGICAL SCIENCES

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

(2011) Piet H. van der Graaf et al.   PHARMACEUTICAL RESEARCH

Building and manipulating neural pathways with microfluidics

(2010) Yevgeny Berdichevsky et al.   LAB ON A CHIP

Endpoints and Analyses to Discern Disease-Modifying Drug Effects in Early Parkinson’s Disease

(2009) Venkatesh Atul Bhattaram et al.   AAPS Journal

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Elucidation of Relationship Between Tumor Size and Survival in Non-Small-Cell Lung Cancer Patients Can Aid Early Decision Making in Clinical Drug Development

(2009) Y Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods

(2009) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Quantitative Disease, Drug, and Trial Models

(2008) Jogarao V.S. Gobburu et al.   Annual Review of Pharmacology and Toxicology

Leveraging Prior Quantitative Knowledge to Guide Drug Development Decisions and Regulatory Science Recommendations: Impact of FDA Pharmacometrics During 2004-2006

(2008) Yaning Wang et al.   JOURNAL OF CLINICAL PHARMACOLOGY