Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

Microfluidic skin chip with vasculature for recapitulating the immune response of the skin tissue

(2020) Bong Shin Kwak et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated Microfluidic Preconcentration and Nucleic Amplification System for Detection of Influenza A Virus H1N1 in Saliva

(2020) Yonghee Kim et al.   Micromachines

An Engineered Infected Epidermis Model for In Vitro Study of the Skin’s Pro-Inflammatory Response

(2020) Maryam Jahanshahi et al.   Micromachines

Diagnosing COVID-19: The Disease and Tools for Detection

(2020) Buddhisha Udugama et al.   ACS Nano

Rapid detection of SARS‐CoV‐2 in saliva: can an endodontist take the lead in point‐of‐care COVID‐19 testing?

(2020) S. Sharma et al.   INTERNATIONAL ENDODONTIC JOURNAL

Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics

(2020) Jorge Ricardo Mejía-Salazar et al.   SENSORS

2019 Novel Coronavirus Disease (COVID-19): Paving the Road for Rapid Detection and Point-of-Care Diagnostics

(2020) Trieu Nguyen et al.   Micromachines

Organ-on-a-Chip for Cancer and Immune Organs Modeling

(2019) Wujin Sun et al.   Advanced Healthcare Materials

Current Biomedical Applications of 3D Printing and Additive Manufacturing

(2019) Pouyan Ahangar et al.   Applied Sciences-Basel

Three-dimensional cultured liver-on-a-Chip with mature hepatocyte-like cells derived from human pluripotent stem cells

(2019) Ken-ichiro Kamei et al.   BIOMEDICAL MICRODEVICES

Application of Microfluidic Chips in Separation and Analysis of Extracellular Vesicles in Liquid Biopsy for Cancer

(2019) Jin Lu et al.   Micromachines

A human-on-a-chip approach to tackling rare diseases

(2019) Camilly P. Pires de Mello et al.   DRUG DISCOVERY TODAY

A microfluidic platform for multi-size 3D tumor culture, monitoring and drug resistance testing

(2019) Wenming Liu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Sample-to-Answer Hepatitis B Virus DNA Detection from Whole Blood on a Centrifugal Microfluidic Platform with Double Rotation Axes

(2019) Lei Li et al.   ACS Sensors

A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions

(2019) Ji Wang et al.   BIOMATERIALS

Microengineered Bioartificial Liver Chip for Drug Toxicity Screening

(2018) Bahman Delalat et al.   ADVANCED FUNCTIONAL MATERIALS

Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials

(2018) Seungkuk Ahn et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases

(2018) John Saliba et al.   Genes

Skin-on-a-Chip: Transepithelial Electrical Resistance and Extracellular Acidification Measurements through an Automated Air-Liquid Interface

(2018) Frank Alexander et al.   Genes

Organs-on-a-Chip Module: A Review from the Development and Applications Perspective

(2018) Juan Eduardo Sosa-Hernández et al.   Micromachines

Towards High Throughput Cell Growth Screening: A New CMOS 8 $\times$ 8 Biosensor Array for Life Science Applications

(2017) Ghazal Nabovati et al.   IEEE Transactions on Biomedical Circuits and Systems

Point-of-Care Testing for Infectious Diseases: Past, Present, and Future

(2017) Thomas R. Kozel et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip

(2017) Stephanie Dauth et al.   JOURNAL OF NEUROPHYSIOLOGY

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

(2017) Samad Ahadian et al.   Advanced Healthcare Materials

Rare Diseases: Drug Discovery and Informatics Resource

(2017) Mingzhu Zhao et al.   Interdisciplinary Sciences-Computational Life Sciences

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Contract research organizations in oncology clinical research: Challenges and opportunities

(2016) Daniel A. Roberts et al.   CANCER

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

(2016) Onur Kilic et al.   LAB ON A CHIP

Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy

(2016) M. Astolfi et al.   LAB ON A CHIP

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy

(2016) Mengying Zhou et al.   Scientific Reports

Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies

(2016) Mohammad Hossein Mohammadi et al.   Advanced Healthcare Materials

Microfluidic-Based Multi-Organ Platforms for Drug Discovery

(2016) Ahmad Rezaei Kolahchi et al.   Micromachines

Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production

(2016) Chia-Wen Tsao   Micromachines

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

(2015) Young Bok Abraham Kang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Review of polymer MEMS micromachining

(2015) Brian J Kim et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Lab-on-a-chip devices: How to close and plug the lab?

(2015) Yuksel Temiz et al.   MICROELECTRONIC ENGINEERING

Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies

(2015) Wooseok Jung et al.   MICROELECTRONIC ENGINEERING

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Microfluidics for advanced drug delivery systems

(2015) Reza Riahi et al.   Current Opinion in Chemical Engineering

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines

(2014) Thibault Bricks et al.   TOXICOLOGY IN VITRO

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments

(2013) Jaewon Park et al.   JOURNAL OF NEUROSCIENCE METHODS

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

(2013) Yun Xiao et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

(2013) Gordana Vunjak-Novakovic et al.   Stem Cell Research & Therapy

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

(2012) Laetitia Shintu et al.   ANALYTICAL CHEMISTRY

Investigation of Hypoxia-Induced Myocardial Injury Dynamics in a Tissue Interface Mimicking Microfluidic Device

(2012) Li Ren et al.   ANALYTICAL CHEMISTRY

Gold nanoisland structures integrated in a lab-on-a-chip for plasmonic detection of bovine growth hormone

(2012) Jayan Ozhikandathil et al.   JOURNAL OF BIOMEDICAL OPTICS

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils

(2012) Sewoon Han et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Commercialization of microfluidic point-of-care diagnostic devices

(2012) Curtis D. Chin et al.   LAB ON A CHIP

Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia

(2012) Elisabetta Iori et al.   PLoS One

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Improvement of HepG2/C3a cell functions in a microfluidic biochip

(2011) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Micropatterning neural cell cultures in 3D with a multi-layered scaffold

(2010) Anja Kunze et al.   BIOMATERIALS

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

(2010) Cheul Cho et al.   BIOTECHNIQUES

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

(2010) Thomas Eschenhagen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Challenges for Rapid Molecular HIV Diagnostics

(2010) Marco L. Schito et al.   JOURNAL OF INFECTIOUS DISEASES

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

What Comes Next?

(2010) George M. Whitesides   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress

(2009) Jianbo Shao et al.   LAB ON A CHIP

Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey

(2008) Geertruida A. Posthuma-Trumpie et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Electrochemical Glucose Sensors and Their Applications in Diabetes Management

(2008) Adam Heller et al.   CHEMICAL REVIEWS

Towards non- and minimally instrumented, microfluidics-based diagnostic devices

(2008) Bernhard Weigl et al.   LAB ON A CHIP

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes

(2008) Hoi Ting Heidi Au et al.   LAB ON A CHIP

Electrochemical Glucose Biosensors

(2007) Joseph Wang   CHEMICAL REVIEWS

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS