Organs-on-a-chip: a new tool for drug discovery

Dielectrophoretically Aligned Carbon Nanotubes to Control Electrical and Mechanical Properties of Hydrogels to Fabricate Contractile Muscle Myofibers

(2013) Javier Ramón-Azcón et al.   ADVANCED MATERIALS

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate

(2013) Akon Higuchi et al.   CHEMICAL REVIEWS

Translating Induced Pluripotent Stem Cells from Bench to Bedside: Application to Retinal Diseases

(2013) Alona O. Cramer et al.   CURRENT GENE THERAPY

Organs-on-a-chip for drug discovery

(2013) Šeila Selimović et al.   CURRENT OPINION IN PHARMACOLOGY

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Lab-on-a-Chip for Anticancer Drug Screening Using Quantum Dots Probe Based Apoptosis Assay

(2013) Liang Zhao et al.   Journal of Biomedical Nanotechnology

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Organs on Chips 2013

(2013) David J. Beebe et al.   LAB ON A CHIP

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Hydrogel-coated microfluidic channels for cardiomyocyte culture

(2013) Nasim Annabi et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Workshop meeting report Organs-on-Chips: human disease models

(2013) Anja van de Stolpe et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers

(2013) Else M. Frohlich et al.   LAB ON A CHIP

Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem

(2013) Andreas Weltin et al.   LAB ON A CHIP

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Receptive cells feel the squeeze

(2013) Tal Nawy   NATURE METHODS

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

Development of a novel microRNA promoter microarray for ChIP-on-chip assay to identify epigenetically regulated microRNAs

(2012) Yoshimasa Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds

(2012) Leonardo Ricotti et al.   Biomedical Materials

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications

(2012) Lih Tyng Cheah et al.   BIOTECHNOLOGY AND BIOENGINEERING

Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system

(2012) Ying Yang et al.   BIOTECHNOLOGY AND BIOENGINEERING

From Laptop to Benchtop to Bedside: Structure-based Drug Design on Protein Targets

(2012) Lu Chen et al.   CURRENT PHARMACEUTICAL DESIGN

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

An inertia enhanced passive pumping mechanism for fluid flow in microfluidic devices

(2012) Pedro J. Resto et al.   LAB ON A CHIP

Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery

(2012) Dmitry A. Markov et al.   LAB ON A CHIP

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

On-chip anticancer drug test of regular tumor spheroids formed in microwells by a distributive microchannel network

(2012) Choong Kim et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

NutriChip: nutrition analysis meets microfluidics

(2012) Qasem Ramadan et al.   LAB ON A CHIP

Pharmacogenomics in clinical practice and drug development

(2012) Andrew R Harper et al.   NATURE BIOTECHNOLOGY

Induced pluripotent stem cells: the new patient?

(2012) Milena Bellin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device

(2012) Brian J. Kirby et al.   PLoS One

Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia

(2012) Elisabetta Iori et al.   PLoS One

Development of Polydimethylsiloxane Substrates with Tunable Elastic Modulus to Study Cell Mechanobiology in Muscle and Nerve

(2012) Rachelle N. Palchesko et al.   PLoS One

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

(2011) Hossein Tavana et al.   BIOMEDICAL MICRODEVICES

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

(2011) Ioannis K. Zervantonakis et al.   Biomicrofluidics

A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors

(2011) Nelita T. Elliott et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modern Drug Discovery Technologies: Opportunities and Challenges in Lead Discovery

(2011) Rafael V. C. Guido et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Engineered cardiac tissues

(2011) Rohin K Iyer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics

(2011) Meggie M.G. Grafton et al.   Integrative Biology

Reversible alteration of calcium dynamics in cardiomyocytes during acute hypoxia transient in a microfluidic platform

(2011) S. Martewicz et al.   Integrative Biology

A radial microfluidic concentration gradient generator with high-density channels for cell apoptosis assay

(2011) Chun-Guang Yang et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Microfluidic devices for modeling cell–cell and particle–cell interactions in the microvasculature

(2011) Balabhaskar Prabhakarpandian et al.   MICROVASCULAR RESEARCH

Slide preparation for single-cell–resolution imaging of fluorescent proteins in their three-dimensional near-native environment

(2011) Hugo J Snippert et al.   Nature Protocols

High Throughput Determination of TGFβ1/SMAD3 Targets in A549 Lung Epithelial Cells

(2011) Yingze Zhang et al.   PLoS One

An algorithm-based topographical biomaterials library to instruct cell fate

(2011) H. V. Unadkat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Control Through Hepatocyte and Adipose Tissue Cross-Talk in a Multicompartmental Modular Bioreactor

(2011) Maria Angela Guzzardi et al.   TISSUE ENGINEERING PART A

Self-Organization of Muscle Cell Structure and Function

(2011) Anna Grosberg et al.   PLoS Computational Biology

The airway epithelium: more than just a structural barrier

(2011) Anthony Tam et al.   Therapeutic Advances in Respiratory Disease

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro

(2010) Valerie L. Cross et al.   BIOMATERIALS

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tumors on chips: oncology meets microfluidics

(2010) Donald Wlodkowic et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Analysis of chemoresistance in lung cancer with a simple microfluidic device

(2010) Lichuan Zhang et al.   ELECTROPHORESIS

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies

(2010) Dana Hoffmann et al.   TOXICOLOGICAL SCIENCES

Microfluidic chip: Next-generation platform for systems biology

(2009) Xiaojun Feng et al.   ANALYTICA CHIMICA ACTA

Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices

(2009) Jong Hwan Sung et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recent developments in PDMS surface modification for microfluidic devices

(2009) Jinwen Zhou et al.   ELECTROPHORESIS

From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures

(2009) Amy L. Paguirigan et al.   Integrative Biology

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Myofibrillar Architecture in Engineered Cardiac Myocytes

(2008) Kevin Kit Parker et al.   CIRCULATION RESEARCH

Evolving concepts in liver tissue modeling and implications forin vitrotoxicology

(2008) André Guillouzo et al.   Expert Opinion on Drug Metabolism & Toxicology

An update on metabolism studies using human hepatocytes in primary culture

(2008) María José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

The cardiac persistent sodium current: an appealing therapeutic target?

(2007) D A Saint   BRITISH JOURNAL OF PHARMACOLOGY