Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats

(2021) Huihui Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Ferroptosis and its emerging roles in cardiovascular diseases

(2021) Ning Li et al.   PHARMACOLOGICAL RESEARCH

Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury

(2021) José Lillo-Moya et al.   Antioxidants

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease

(2020) Nao Yan et al.   Frontiers in Neuroscience

Heat stress induces RIP1/RIP3-dependent necroptosis through the MAPK, NF-κB, and c-Jun signaling pathways in pulmonary vascular endothelial cells

(2020) Wei Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

miR-34a regulates adipogenesis in porcine intramuscular adipocytes by targeting ACSL4

(2020) Wenwen Wang et al.   BMC GENETICS

Double agents of cell death: novel emerging functions of apoptotic regulators

(2020) Heather M. Lamb   FEBS Journal

Lipids and Lipid Mediators Associated with the Risk and Pathology of Ischemic Stroke

(2020) Anna Kloska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury

(2020) Sean M. Davidson et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy

(2020) Aishika Datta et al.   Translational Stroke Research

Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy

(2020) Sanae Miyake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury

(2020) Li-Qun Lu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial redox-driven mitofusin 2 S-glutathionylation promotes neuronal necroptosis via disrupting ER-mitochondria crosstalk in cadmium-induced neurotoxicity

(2020) Lin Che et al.   CHEMOSPHERE

NMDA Receptor Modulates Spinal Iron Accumulation Via Activating DMT1(-)IRE in Remifentanil-Induced Hyperalgesia

(2020) Ruichen Shu et al.   JOURNAL OF PAIN

Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation

(2020) Yue Zhang et al.   Cell Death & Disease

Cross Talk Between Ferroptosis and Cerebral Ischemia

(2020) Xu She et al.   Frontiers in Neuroscience

Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production

(2020) Jin Liu et al.   Frontiers in Pharmacology

Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

(2020) Bin Lan et al.   Journal of Integrative Medicine-JIM

Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems

(2020) Peter Kaplan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

(2020) Christian B. Billesbølle et al.   NATURE

ROS-Mediated Necroptosis Is Involved in Iron Overload-Induced Osteoblastic Cell Death

(2020) Qing Tian et al.   Oxidative Medicine and Cellular Longevity

Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

(2020) Jie Liu et al.   Frontiers in Cellular Neuroscience

USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death

(2020) Shuxian Ma et al.   Frontiers in Physiology

Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease

(2020) Chiara Milanese et al.   CELL DEATH AND DIFFERENTIATION

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

(2020) Wei Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils

(2020) Xue Guan et al.   LIFE SCIENCES

Posttranslational Modifications in Ferroptosis

(2020) Xiang Wei et al.   Oxidative Medicine and Cellular Longevity

Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner

(2019) Wenjing Xian et al.   BRAIN RESEARCH

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

(2019) Núria DeGregorio-Rocasolano et al.   Frontiers in Neuroscience

Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)

(2019) Wen‑Fang Zhang et al.   Experimental and Therapeutic Medicine

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration

(2019) Mariacarmela Allocca et al.   Science Signaling

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Ligustroflavone reduces necroptosis in rat brain after ischemic stroke through targeting RIPK1/RIPK3/MLKL pathway

(2019) Yi-Yue Zhang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis

(2019) Feng-Jun Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)

(2019) Yuping Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

GCN2 suppression attenuates cerebral ischemia in mice by reducing apoptosis and endoplasmic reticulum (ER) stress through the blockage of FoxO3a-regulated ROS production

(2019) Wen-Zhen Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lobe specificity of iron-binding to transferrin modulates murine erythropoiesis and iron homeostasis

(2019) Nermi L. Parrow et al.   BLOOD

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

Necroptosis in the Pathophysiology of Disease

(2019) Mitri K. Khoury et al.   AMERICAN JOURNAL OF PATHOLOGY

Cardiotoxicity of sorafenib is mediated through elevation of ROS level and CaMKII activity and dysregulation of calcium homoeostasis

(2019) Wenzhuo Ma et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Progranulin protects against cerebral ischemia-reperfusion (I/R) injury by inhibiting necroptosis and oxidative stress

(2019) Xiaogang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondria regulation in ferroptosis

(2019) Hai Wang et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε

(2019) Ana‐Marija Vučković et al.   FEBS LETTERS

In vitro metabolism of pyrrolizidine alkaloids – Metabolic degradation and GSH conjugate formation of different structure types

(2019) Ina Geburek et al.   FOOD AND CHEMICAL TOXICOLOGY

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

(2019) Xueying Guan et al.   LIFE SCIENCES

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

ACSL4 suppresses glioma cells proliferation via activating ferroptosis

(2019) Jing Cheng et al.   ONCOLOGY REPORTS

β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation

(2019) Renpeng Zhou et al.   STROKE

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

(2019) Eunhee Park et al.   Cell Death & Disease

Molecular Insights into the Mechanism of Necroptosis: The Necrosome as a Potential Therapeutic Target

(2019) Jing Chen et al.   Cells

Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes

(2019) Xiaoxue Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanism of colorectal carcinogenesis triggered by heme iron from red meat

(2019) Nina Seiwert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation

(2019) Jin-Hui Liu et al.   EXPERIMENTAL NEUROLOGY

EPA and DHA attenuate deoxynivalenol‐induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway

(2019) Kan Xiao et al.   FASEB JOURNAL

Endothelin-1-Induced Ischemic Damage and Functional Impairment Is Mediated Primarily by NR2B-Containing NMDA Receptors

(2019) Andrew W. Hume et al.   NEUROTOXICITY RESEARCH

Metformin Protects against Oxidative Stress Injury Induced by Ischemia/Reperfusion via Regulation of the lncRNA-H19/miR-148a-3p/Rock2 Axis

(2019) Jing Zeng et al.   Oxidative Medicine and Cellular Longevity

Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson’s disease

(2019) Si-Tong Feng et al.   PHARMACOLOGICAL RESEARCH

The potential role of acrolein in plant ferroptosis-like cell death

(2019) Péter Hajdinák et al.   PLoS One

Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors

(2018) Shenglin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells

(2018) Yung Hyun Choi   BIOMEDICINE & PHARMACOTHERAPY

Increased sympathovagal imbalance evaluated by heart rate variability is associated with decreased T2* MRI and left ventricular function in transfusion-dependent thalassemia patients

(2018) Sintip Pattanakuhar et al.   BIOSCIENCE REPORTS

Reperfusion therapy in acute ischemic stroke: dawn of a new era?

(2018) Sonu Bhaskar et al.   BMC Neurology

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

(2018) Miguel Mompeán et al.   CELL

The role of Ca 2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

(2018) Pamela Maher et al.   CELL CALCIUM

RIPK3/MLKL-Mediated Neuronal Necroptosis Modulates the M1/M2 Polarization of Microglia/Macrophages in the Ischemic Cortex

(2018) Jiping Yang et al.   CEREBRAL CORTEX

To eat or not to eat — the metabolic flavor of ferroptosis

(2018) Minghui Gao et al.   CURRENT OPINION IN CELL BIOLOGY

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression

(2018) Zhen Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice

(2018) Mohamad El Amki et al.   MOLECULAR NEUROBIOLOGY

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

Temporal Pattern and Crosstalk of Necroptosis Markers with Autophagy and Apoptosis Associated Proteins in Ischemic Hippocampus

(2018) Fari Ryan et al.   NEUROTOXICITY RESEARCH

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Iron Overload Exacerbates the Risk of Hemorrhagic Transformation After tPA (Tissue-Type Plasminogen Activator) Administration in Thromboembolic Stroke Mice

(2018) Isaac García-Yébenes et al.   STROKE

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

(2018) Deepaneeta Sarmah et al.   Translational Stroke Research

The Role of Necroptosis in Cardiovascular Disease

(2018) Shi Zhe-Wei et al.   Frontiers in Pharmacology

Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway

(2018) Pingjun Zhu et al.   Redox Biology

Current advances in ischemic stroke research and therapies

(2018) Derek Barthels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice

(2018) Bao-Shu Xie et al.   CNS Neuroscience & Therapeutics

Memory deficits and hippocampal inflammation in cerebral hypoperfusion and reperfusion in male rats: Neuroprotective role of vanillic acid

(2018) Seyed Esmaeil Khoshnam et al.   LIFE SCIENCES

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

(2018) Chuanhong Wu et al.   Scientific Reports

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Iron Homeostasis in Healthy Kidney and its Role in Acute Kidney Injury

(2018) Yogesh Scindia et al.   SEMINARS IN NEPHROLOGY

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

(2018) Wout Oosterheert et al.   Nature Communications

Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke

(2017) Tatsuya Fukuta et al.   FASEB JOURNAL

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Redistribution of Cerebral Blood Flow during Severe Hypovolemia and Reperfusion in a Sheep Model: Critical Role of α1-Adrenergic Signaling

(2017) René Schiffner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats

(2017) Rongli Yang et al.   NEUROSCIENCE LETTERS

Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke

(2017) Jinkwon Kim et al.   STROKE

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

(2017) Farhan Basit et al.   Cell Death & Disease

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

The degradation of mixed lineage kinase domain-like protein promotes neuroprotection after ischemic brain injury

(2017) Yanlong Zhou et al.   Oncotarget

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

(2017) Meng-Shian Chen et al.   Oncotarget

Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis

(2017) Jing Tian et al.   Translational Stroke Research

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

(2017) Mei Yang et al.   Frontiers in Neuroscience

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

(2017) Yongjuan Xin et al.   Cell Discovery

Ceftriaxone- and N-acetylcysteine-induced brain tolerance to ischemia: Influence on glutamate levels in focal cerebral ischemia

(2017) Weronika Krzyżanowska et al.   PLoS One

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

(2017) Xiao-Sa Yang et al.   Scientific Reports

Iron uptake and transport across physiological barriers

(2016) Kari A. Duck et al.   BIOMETALS

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

(2016) M Cristina de Almagro et al.   CELL DEATH AND DIFFERENTIATION

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

(2016) Yuan Ying et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion

(2016) Farinoosh Fakharnia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Heme Oxygenases in Cardiovascular Health and Disease

(2016) Anita Ayer et al.   PHYSIOLOGICAL REVIEWS

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock protein 90 regulates necroptosis by modulating multiple signaling effectors

(2016) C K Yang et al.   Cell Death & Disease

Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

(2015) Simone Hanna Brütsch et al.   ANTIOXIDANTS & REDOX SIGNALING

A comparative study of myocardial molecular phenotypes of two tfr2β null mice: Role in ischemia/reperfusion

(2015) Martina Boero et al.   BIOFACTORS

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

(2015) C J Kearney et al.   CELL DEATH AND DIFFERENTIATION

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

The Many Roles of Statins in Ischemic Stroke

(2015) Jingru Zhao et al.   Current Neuropharmacology

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

(2015) Jason Karch et al.   PLoS One

Huangqi−Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats

(2014) Jinyi Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hemorrhagic Transformation after Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke: Mechanisms, Models, and Biomarkers

(2014) Wei Wang et al.   MOLECULAR NEUROBIOLOGY

Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin

(2014) X Wang et al.   MOLECULAR PSYCHIATRY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

The IRP/IRE system in vivo: insights from mouse models

(2014) Nicole Wilkinson et al.   Frontiers in Pharmacology

Necroptosis: is there a role for mitochondria?

(2014) Kurt D. Marshall et al.   Frontiers in Physiology

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model

(2013) Chen-Huan Lin et al.   NEUROBIOLOGY OF DISEASE

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses

(2012) F. Zhang et al.   HAEMATOLOGICA

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

(2012) Joanna M Wardlaw et al.   LANCET

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury

(2011) P. Zhang et al.   NEUROSCIENCE

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

(2011) Hui Ding et al.   PLoS One

Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat

(2010) Ui Jin Park et al.   ACTA NEUROPATHOLOGICA

Leptin Augments Cerebral Hemodynamic Reserve after Three-Vessel Occlusion: Distinct Effects on Cerebrovascular Tone and Proliferation in a Nonlethal Model of Hypoperfused Rat Brain

(2010) Hans-Joerg Busch et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Periventricular White Matter Lucencies Relate to Low Vitamin B12 Levels in Patients With Small Vessel Stroke

(2009) Barbe Pieters et al.   STROKE

An update on iron physiology

(2009) Manuel Muñoz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPARγ in cardiac fibroblasts

(2008) Dan Huang et al.   CARDIOVASCULAR RESEARCH

Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism

(2007) Jonathan S. Oakhill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Lipid peroxidation in stroke patients

(2007) Gianna Ferretti et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE