Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Ferroptosis: bug or feature?

(2017) Scott J. Dixon   IMMUNOLOGICAL REVIEWS

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

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Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

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Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

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Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

An essential role for functional lysosomes in ferroptosis of cancer cells

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Ferroptosis is an autophagic cell death process

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Mechanisms of ferroptosis

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xCT deficiency induces autophagy via endoplasmic reticulum stress activated p38-mitogen-activated protein kinase and mTOR in sut melanocytes

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Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration

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Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration

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Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates

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Glutathione Depletion Induces Spermatogonial Cell Autophagy

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Dehydroepiandrosterone prevents linoleic acid-induced endothelial cell senescence by increasing autophagy

(2015) Min Jung Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Glutaminolysis and Transferrin Regulate Ferroptosis

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Oxidative stress and autophagy: the clash between damage and metabolic needs

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Synchronized renal tubular cell death involves ferroptosis

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The role of iron and reactive oxygen species in cell death

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Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence

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Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

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Autophagy May Precede Cellular Senescence of Bile Ductular Cells in Ductular Reaction in Primary Biliary Cirrhosis

(2011) Motoko Sasaki et al.   DIGESTIVE DISEASES AND SCIENCES

Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways

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Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

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Calcium Overload Is A Critical Step in Programmed Necrosis of ARPE-19 Cells Induced by High-Concentration H2O2

(2010) Guang-Yu LI et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis

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Oxidation and age-related macular degeneration: insights from molecular biology

(2010) Sam Khandhadia et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Autophagy, reactive oxygen species and the fate of mammalian cells

(2010) Irena Szumiel   FREE RADICAL RESEARCH

Autophagy: cellular and molecular mechanisms

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Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

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Senescent Keratinocytes Die by Autophagic Programmed Cell Death

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Prematurely senescent ARPE-19 cells display features of age-related macular degeneration

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