Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

(2017) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats

(2017) Rongli Yang et al.   NEUROSCIENCE LETTERS

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis

(2017) Kelby W. Wegner et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter

(2017) Zhentao Yang et al.   Cell Reports

Myricitrin Protects Cardiomyocytes from Hypoxia/Reoxygenation Injury: Involvement of Heat Shock Protein 90

(2017) Min Wang et al.   Frontiers in Pharmacology

Mechanisms of Hsp90 regulation

(2016) C. Prodromou   BIOCHEMICAL JOURNAL

An outline of necrosome triggers

(2016) Tom Vanden Berghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biomarkers for the detection of necroptosis

(2016) Sudan He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Raf kinase inhibitor protein regulates oxygen-glucose deprivation-induced PC12 cells apoptosis through the NF-κB and ERK pathways

(2016) Li Su et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Inhibition of calpain on oxygen glucose deprivation-induced RGC-5 necroptosis

(2016) Shuang Chen et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

(2016) Andrea Schulze et al.   Nature Chemical Biology

Protective mechanisms of microRNA-27a against oxygen-glucose deprivation-induced injuries in hippocampal neurons

(2016) Xing Fen et al.   Neural Regeneration Research

The Toxic Effect of ALLN on Primary Rat Retinal Neurons

(2016) Na Li et al.   NEUROTOXICITY RESEARCH

Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β

(2016) Kendrick H. Yim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Necroptosis contributes to methamphetamine-induced cytotoxicity in rat cortical neurons

(2016) Kun Xiong et al.   TOXICOLOGY IN VITRO

An evolutionary perspective on the necroptotic pathway

(2016) Yves Dondelinger et al.   TRENDS IN CELL BIOLOGY

Heat shock protein 90 regulates necroptosis by modulating multiple signaling effectors

(2016) C K Yang et al.   Cell Death & Disease

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis

(2016) X M Zhao et al.   Cell Death & Disease

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

(2016) A V Jacobsen et al.   Cell Death & Disease

Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation

(2015) Wei Ding et al.   BMC NEUROSCIENCE

Regulation and function of the human HSP90AA1 gene

(2015) Abbey D. Zuehlke et al.   GENE

Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen-glucose deprivation-induced necroptosis

(2015) LIMING YUAN et al.   Molecular Medicine Reports

Enriched Endogenous Omega-3 Polyunsaturated Fatty Acids Protect Cortical Neurons from Experimental Ischemic Injury

(2015) Zhe Shi et al.   MOLECULAR NEUROBIOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Necrostatin-1 protection of dopaminergic neurons

(2015) Yan-bo Cheng et al.   Neural Regeneration Research

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

(2015) Dianrong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide

(2014) San-Hong Jiang et al.   BMC Complementary and Alternative Medicine

Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure

(2014) Lei Shang et al.   BMC NEUROSCIENCE

Heat shock protein 90β stabilizes focal adhesion kinase and enhances cell migration and invasion in breast cancer cells

(2014) Xiangyang Xiong et al.   EXPERIMENTAL CELL RESEARCH

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Necroptosis, in vivo detection in experimental disease models

(2014) Sandrine Jouan-Lanhouet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response

(2013) Ju-Fang Huang et al.   BMC NEUROSCIENCE

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats

(2013) John W. Thompson et al.   PLoS One

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

The role of heat shock protein 90 in modulating ischemia–reperfusion injury in the kidney

(2012) Stephen O'Neill et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The role of Hsp90 in protein complex assembly

(2011) Taras Makhnevych et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Secreted heat shock protein-90 (Hsp90) in wound healing and cancer

(2011) Wei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons

(2011) Wei-Wei Chen et al.   JOURNAL OF NEUROCHEMISTRY

The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse

(2011) Iwona Grad et al.   PLoS One

RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation

(2011) YoungSik Cho et al.   PLoS One

Heat Shock Proteins: Cell Protection through Protein Triage

(2011) David Lanneau et al.   TheScientificWorldJOURNAL

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

(2010) H. Takai et al.   GENES & DEVELOPMENT

The Effect of Chaperonin Buffering on Protein Evolution

(2010) Tom A. Williams et al.   Genome Biology and Evolution

Heat Shock Protein 90 Inhibition in Lung Cancer

(2010) Takeshi Shimamura et al.   Journal of Thoracic Oncology

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Plasminogen Enhances Neuritogenesis on Laminin-1

(2009) A. Gutierrez-Fernandez et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of Dendrobium alkaloids on rat cortical neurons injured by oxygen-glucose deprivation and reperfusion

(2009) Q. Wang et al.   PHYTOMEDICINE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Transforming Growth Factor   (TGF )-Stimulated Secretion of HSP90 : Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF -Rich Environment during Wound Healing

(2008) C.-F. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY