Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production

Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy

(2019) Yueting Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke

(2019) Yiming Deng et al.   STROKE

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches

(2018) Shashank Shekhar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes

(2018) Jieyu Chen et al.   NEUROPHARMACOLOGY

Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management

(2018) Anil Kumar Rana et al.   NEUROPHARMACOLOGY

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway

(2018) Yong Ni et al.   NEUROSCIENCE

Necrostatin-1 Improves Long-term Functional Recovery Through Protecting Oligodendrocyte Precursor Cells After Transient Focal Cerebral Ischemia in Mice

(2018) Yingzhu Chen et al.   NEUROSCIENCE

Different doses of tenecteplase vs alteplase in thrombolysis therapy of acute ischemic stroke: evidence from randomized controlled trials

(2018) Na Xu et al.   Drug Design Development and Therapy

Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke

(2018) Wei Li et al.   NEUROSCIENCE

CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke

(2018) Yuan Qin et al.   ACTA PHARMACOLOGICA SINICA

Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke

(2017) Hongxia Cai et al.   MOLECULAR THERAPY

Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function

(2017) Neil R. Sims et al.   NEUROCHEMISTRY INTERNATIONAL

Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia–reperfusion brain injury

(2017) Yong-Ming Zhu et al.   NEUROSCIENCE

Tissue plasminogen activator mediates deleterious complement cascade activation in stroke

(2017) Xue-Jun Zhao et al.   PLoS One

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

(2016) Bettina Hjelm Clausen et al.   ACTA NEUROPATHOLOGICA

Ischemia Reperfusion Injury Triggers TNFα Induced-Necroptosis in Rat Retina

(2016) Cho Rong Kim et al.   CURRENT EYE RESEARCH

LLDT-8 protects against cerebral ischemia/reperfusion injury by suppressing post-stroke inflammation

(2016) Yanke Chen et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

(2016) Hong Fan et al.   Molecular Neurodegeneration

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

(2016) Xi Chen et al.   Scientific Reports

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice

(2015) S. P. Singh et al.   Disease Models & Mechanisms

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production

(2015) Ryeojin Ko et al.   Nature Communications

GSK-3 - at the crossroads of cell death and survival

(2014) U. Maurer et al.   JOURNAL OF CELL SCIENCE

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Influence of the extracellular matrix on endogenous and transplanted stem cells after brain damage

(2014) Lars Roll et al.   Frontiers in Cellular Neuroscience

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

Inhibition of glycogen synthase kinase-3β by lithium chloride suppresses 6-hydroxydopamine-induced inflammatory response in primary cultured astrocytes

(2013) Hong-Mei Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

A novel role for RIP1 kinase in mediating TNFα production

(2012) D E Christofferson et al.   Cell Death & Disease

Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy

(2011) Min Xu et al.   ACTA PHARMACOLOGICA SINICA

GSK-3β inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury

(2011) Xiaogang Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition

(2011) Francois Renault-Mihara et al.   EMBO Molecular Medicine

Blocking epidermal growth factor receptor attenuates reactive astrogliosis through inhibiting cell cycle progression and protects against ischemic brain injury in rats

(2011) Qin Yang et al.   JOURNAL OF NEUROCHEMISTRY

Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production

(2011) Alessandra Valerio et al.   JOURNAL OF NEUROCHEMISTRY

Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress

(2011) Jonathan M. Gall et al.   KIDNEY INTERNATIONAL

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Using Small Molecule GSK3β Inhibitors to Treat Inflammation

(2010) G. Klamer et al.   CURRENT MEDICINAL CHEMISTRY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential

(2009) Annalisa Buffo et al.   BIOCHEMICAL PHARMACOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

Ser9 phosphorylation of mitochondrial GSK-3β is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis

(2008) Katsuhiko Ohori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Persistent inflammation alters the function of the endogenous brain stem cell compartment

(2008) Stefano Pluchino et al.   BRAIN

Inflammatory Cytokines in Acute Ischemic Stroke

(2008) Antonino Tuttolomondo et al.   CURRENT PHARMACEUTICAL DESIGN

The death domain-containing kinase RIP1 regulates p27Kip1 levels through the PI3K–Akt–forkhead pathway

(2008) Seongmi Park et al.   EMBO REPORTS