Double agents of cell death: novel emerging functions of apoptotic regulators

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death

(2019) Jurgen Kriel et al.   CELL DEATH AND DIFFERENTIATION

Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives

(2019) Hui Cong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia

(2019) Eugen Tausch et al.   HAEMATOLOGICA

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

(2019) Piers Blombery et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bivalent SMAC Mimetics for Treating Cancer by Antagonizing Inhibitor of Apoptosis Proteins

(2019) Hongping Zhu et al.   ChemMedChem

Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

(2019) Andrea Urbani et al.   Nature Communications

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

(2019) Nelli Mnatsakanyan et al.   Nature Communications

Autophagy regulates apoptosis by targeting NOXA for degradation

(2018) Jingchao Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

(2018) Young-Sun Lee et al.   MOLECULAR CANCER RESEARCH

Mitochondrial permeability transition pore: Back to the drawing board

(2018) Christos Chinopoulos   NEUROCHEMISTRY INTERNATIONAL

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors

(2018) Dongshi Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-dependent cell death – where, how and why a cell eats itself to death

(2018) Shani Bialik et al.   JOURNAL OF CELL SCIENCE

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Crashing the computer: apoptosis vs. necroptosis in neuroinflammation

(2018) Bradlee L. Heckmann et al.   CELL DEATH AND DIFFERENTIATION

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

(2018) James E. Vince et al.   Cell Reports

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages

(2018) Dhruv Chauhan et al.   Cell Reports

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Insane in the membrane: a structural perspective of MLKL function in necroptosis

(2017) Emma J Petrie et al.   IMMUNOLOGY AND CELL BIOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG

(2017) Shintaro Nakajima et al.   PLoS One

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

(2017) Shuzhen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression

(2017) Se Hoon Hong et al.   Oncotarget

ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival

(2017) Gary X. Wang et al.   Cell Reports

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Tumor necrosis factor-alpha regulates photoreceptor cell autophagy after retinal detachment

(2017) Jia Xie et al.   Scientific Reports

Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model

(2016) Ana Mesquita et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The mitochondrial permeability transition pore in AD 2016: An update

(2016) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

(2016) Jong-Lyel Roh et al.   CANCER LETTERS

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

(2016) Katharina Rohde et al.   CELL DEATH AND DIFFERENTIATION

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Necrosome core machinery: MLKL

(2016) Jing Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways

(2016) Adeeb Derakhshan et al.   CLINICAL CANCER RESEARCH

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise

(2016) Kristopher A. Sarosiek et al.   FEBS Journal

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells

(2016) C Safferthal et al.   ONCOGENE

Ironing out how p53 regulates ferroptosis

(2016) Maureen E. Murphy   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

(2016) Gabriela Brumatti et al.   Science Translational Medicine

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL

(2016) Scott McComb et al.   Science Translational Medicine

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties

(2016) Valentina Izzo et al.   TRENDS IN CELL BIOLOGY

Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells

(2016) Juraj Bodo et al.   Oncotarget

Glucosidase II β-subunit, a novel substrate for caspase-3-like activity in rice, plays as a molecular switch between autophagy and programmed cell death

(2016) Jing Cui et al.   Scientific Reports

Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells

(2016) Haizhong Huo et al.   PLoS One

BCL2L11/Bim as a dual-agent regulating autophagy and apoptosis in drug resistance

(2015) Yun Dai et al.   Autophagy

ABT-737 sensitizes curcumin-induced anti-melanoma cell activity through facilitating mPTP death pathway

(2015) Teng Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists

(2015) Shawn T. Beug et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

(2015) Marcos A. Carpio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting extrinsic apoptosis in cancer: Challenges and opportunities

(2015) Simone Fulda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

(2015) M C de Almagro et al.   Cell Death & Disease

Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria

(2015) Qun Chen et al.   PLoS One

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

(2015) Jason Karch et al.   PLoS One

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Phase I Dose-Escalation Study of LCL161, an Oral Inhibitor of Apoptosis Proteins Inhibitor, in Patients With Advanced Solid Tumors

(2014) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy

(2014) Emilie Hollville et al.   MOLECULAR CELL

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner

(2014) Mohamed Elgendy et al.   Nature Communications

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

Necroptosis: is there a role for mitochondria?

(2014) Kurt D. Marshall et al.   Frontiers in Physiology

Autophagy activity contributes to programmed cell death inCaenorhabditis elegans

(2013) Haibin Wang et al.   Autophagy

BH3-only proteins, Bmf and Bim, in autophagy

(2013) Monica Delgado et al.   CELL CYCLE

The Bcl-2 Protein Family Member Bok Binds to the Coupling Domain of Inositol 1,4,5-Trisphosphate Receptors and Protects Them from Proteolytic Cleavage

(2013) Jacqualyn J. Schulman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Bcl-2 with the Autophagy-related GABAAReceptor-associated Protein (GABARAP)

(2013) Peixiang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Complex between Atg7 and Caspase-9

(2013) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uba1 functions in Atg7- and Atg3-independent autophagy

(2013) Tsun-Kai Chang et al.   NATURE CELL BIOLOGY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of RIP1 Inhibition by Necrostatins

(2013) Tian Xie et al.   STRUCTURE

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members

(2012) Denise Tischner et al.   APOPTOSIS

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules

(2012) Shouqing Luo et al.   MOLECULAR CELL

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Bcl-xLregulates mitochondrial energetics by stabilizing the inner membrane potential

(2011) Ying-bei Chen et al.   JOURNAL OF CELL BIOLOGY

Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis

(2011) K. M. Irrinki et al.   MOLECULAR AND CELLULAR BIOLOGY

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

(2011) Assaf D. Rubinstein et al.   MOLECULAR CELL

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study

(2011) S Shen et al.   ONCOGENE

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak

(2011) C Wang et al.   ONCOGENE

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner

(2010) Marc Germain et al.   EMBO JOURNAL

Secondary necrosis: The natural outcome of the complete apoptotic program

(2010) Manuel T. Silva   FEBS LETTERS

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

The Receptor Interacting Protein 1 Inhibits p53 Induction through NF- B Activation and Confers a Worse Prognosis in Glioblastoma

(2009) S. Park et al.   CANCER RESEARCH

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer

(2008) Myoung Sook Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY