Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

Ferroptotic agent‐induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome

(2020) Young‐Sun Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury

(2020) Li-Qun Lu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

(2020) Bin Lan et al.   Journal of Integrative Medicine-JIM

NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms

(2019) Naiara Santana-Codina et al.   HAEMATOLOGICA

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

(2019) Maria Quiles del Rey et al.   Frontiers in Neuroscience

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

(2019) Núria DeGregorio-Rocasolano et al.   Frontiers in Neuroscience

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

KCNQ1OT1 promotes autophagy by regulating miR‐200a/FOXO3/ATG7 pathway in cerebral ischemic stroke

(2019) Shijia Yu et al.   AGING CELL

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Lipid Reshaping and Lipophagy Are Induced in a Modeled Ischemia-Reperfusion Injury of Blood Brain Barrier

(2019) Elena Lonati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

Mitochondria regulation in ferroptosis

(2019) Hai Wang et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

(2019) Xueying Guan et al.   LIFE SCIENCES

ACSL4 suppresses glioma cells proliferation via activating ferroptosis

(2019) Jing Cheng et al.   ONCOLOGY REPORTS

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

(2019) Eunhee Park et al.   Cell Death & Disease

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ferroptosis is a lysosomal cell death process

(2018) Huan Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models

(2018) H. Karatas et al.   BRAIN RESEARCH

Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: Involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway

(2018) Guang Yang et al.   BRAIN RESEARCH BULLETIN

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

(2018) Anja Jelinek et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway

(2018) Yong Ni et al.   NEUROSCIENCE

Autophagy in ischemic stroke

(2018) Pei Wang et al.   PROGRESS IN NEUROBIOLOGY

Iron Overload Exacerbates the Risk of Hemorrhagic Transformation After tPA (Tissue-Type Plasminogen Activator) Administration in Thromboembolic Stroke Mice

(2018) Isaac García-Yébenes et al.   STROKE

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

(2018) Nuria DeGregorio-Rocasolano et al.   Redox Biology

Diverse roles of mitochondria in ischemic stroke

(2018) Jenq-Lin Yang et al.   Redox Biology

Emerging cellular functions of the lipid metabolizing enzyme 15-Lipoxygenase-1

(2018) Melis Çolakoğlu et al.   CELL PROLIFERATION

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Lipid storage and lipophagy regulates ferroptosis

(2018) Yuansong Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-181b-5p suppresses starvation-induced cardiomyocyte autophagy by targeting Hspa5

(2018) Liuhui Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MALAT1 lncRNA Induces Autophagy and Protects Brain Microvascular Endothelial Cells Against Oxygen–Glucose Deprivation by Binding to miR-200c-3p and Upregulating SIRT1 Expression

(2018) Shan Wang et al.   NEUROSCIENCE

Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway

(2017) Shu-Hui Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome

(2017) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis

(2017) Sergei A. Novgorodov et al.   JOURNAL OF LIPID RESEARCH

The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex

(2017) Siyu Wang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT

(2017) Mustafa Caglar Beker et al.   MOLECULAR NEUROBIOLOGY

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Dexmedetomidine Protects Mouse Brain from Ischemia-Reperfusion Injury via Inhibiting Neuronal Autophagy through Up-Regulating HIF-1α

(2017) Cong Luo et al.   Frontiers in Cellular Neuroscience

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

(2017) Chunguang Yang et al.   Drug Design Development and Therapy

Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia

(2017) Ya-Jun Liu et al.   BMC Anesthesiology

Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis

(2017) Jing Tian et al.   Translational Stroke Research

Sodium hydrosulfide attenuates cerebral ischemia/reperfusion injury by suppressing overactivated autophagy in rats

(2017) Wen-Wu Jiang et al.   FEBS Open Bio

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

“Only a Life Lived for Others Is Worth Living”: Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions

(2017) Yulia Y. Tyurina et al.   ANTIOXIDANTS & REDOX SIGNALING

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Associations between autophagy, the ubiquitin-proteasome system and endoplasmic reticulum stress in hypoxia-deoxygenation or ischemia-reperfusion

(2016) Tao Fan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

N-Acetylcysteine and Ceftriaxone as Preconditioning Strategies in Focal Brain Ischemia: Influence on Glutamate Transporters Expression

(2016) Weronika Krzyzanowska et al.   NEUROTOXICITY RESEARCH

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway

(2015) Feng Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway

(2015) WEILIN LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced Autophagy and Apoptosis via Interplay with Beclin 1

(2015) Jiong Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutathione Depletion Induces Spermatogonial Cell Autophagy

(2015) Héctor Mancilla et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1)

(2015) Koji Aoyama et al.   MOLECULES

Ischemic Preconditioning Mediates Neuroprotection against Ischemia in Mouse Hippocampal CA1 Neurons by Inducing Autophagy

(2015) Chunlin Gao et al.   PLoS One

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer

(2015) Ulises D. Orlando et al.   Oncotarget

Bcl-2 Phosphorylation Triggers Autophagy Switch and Reduces Mitochondrial Damage in Limb Remote Ischemic Conditioned Rats After Ischemic Stroke

(2015) Zhifeng Qi et al.   Translational Stroke Research

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

The Mammalian Circadian Clock Gene Per2 Modulates Cell Death in Response to Oxidative Stress

(2015) Maria Chiara Magnone et al.   Frontiers in Neurology

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia

(2014) Pei Wang et al.   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

w007B protects brain against ischemia–reperfusion injury in rats through inhibiting inflammation, apoptosis and autophagy

(2014) Qixin Bu et al.   BRAIN RESEARCH

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

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(2014) Lorenzo Galluzzi et al.   NATURE CELL BIOLOGY

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy

(2014) Peng Wang et al.   NEUROCHEMICAL RESEARCH

Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

(2014) Saif Ahmad et al.   NEUROTOXICOLOGY

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

(2014) Seung-Hoon Baek et al.   STROKE

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning

(2013) Bo Gao et al.   ACTA PHARMACOLOGICA SINICA

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

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(2013) Hitoshi Nakatogawa   Essays in Biochemistry

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Autophagy in Human Health and Disease

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HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

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(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke

(2012) Kazim Yigitkanli et al.   ANNALS OF NEUROLOGY

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

(2012) Enrico Desideri et al.   Autophagy

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning

(2012) Rui Sheng et al.   Autophagy

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(2012) Marco T. Núñez et al.   BIOMETALS

Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia

(2012) Suresh L Mehta et al.   BMC NEUROSCIENCE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

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Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling

(2012) Anton Pekcec et al.   FASEB JOURNAL

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Lipid Peroxidation Product 4-Hydroxy-trans-2-nonenal Causes Endothelial Activation by Inducing Endoplasmic Reticulum Stress

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(2012) E. P. Thi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2012) Isaac García-Yébenes et al.   NEUROCHEMISTRY INTERNATIONAL

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(2011) Marcus Conrad et al.   AMINO ACIDS

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(2011) Noboru Mizushima et al.   CELL

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(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats

(2011) Li Li et al.   EXPERIMENTAL NEUROLOGY

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(2011) Tanea T. Reed   FREE RADICAL BIOLOGY AND MEDICINE

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Disruption of circadian clocks has ramifications for metabolism, brain, and behavior

(2011) I. N. Karatsoreos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat

(2010) Ui Jin Park et al.   ACTA NEUROPATHOLOGICA

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum

(2010) J Lian et al.   CELL DEATH AND DIFFERENTIATION

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

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(2010) Alexandra Kollara et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

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(2010) Christian Behrends et al.   NATURE

Baicalein is neuroprotective in rat MCAO model: Role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2

(2010) Lili Cui et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

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(2009) Claudine Kraft et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

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(2009) Douglas B Kell   BMC Medical Genomics

Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action

(2009) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats

(2009) Venkata Prasuja Nakka et al.   NEUROTOXICITY RESEARCH

Ferritins: A family of molecules for iron storage, antioxidation and more

(2008) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia–ischemia

(2008) Georgios Papazisis et al.   PHARMACOLOGICAL RESEARCH

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

(2008) P. K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2008) Chuck T. Chen et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS