Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome

(2016) Kenta Moriwaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

(2016) Nieves Peltzer et al.   TRENDS IN CELL BIOLOGY

Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment

(2015) Eugene Varfolomeev et al.   BIOCHEMICAL JOURNAL

Death in the fast lane: what's next for necroptosis?

(2015) Andrew Oberst   FEBS Journal

Immunoaffinity Enrichment Coupled to Quantitative Mass Spectrometry Reveals Ubiquitin-Mediated Signaling Events

(2015) Kebing Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

(2015) M C de Almagro et al.   Cell Death & Disease

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

OTUB1 modulates c-IAP1 stability to regulate signalling pathways

(2013) Tatiana Goncharov et al.   EMBO JOURNAL

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Linear ubiquitination-mediated NF- B regulation and its related disorders

(2013) F. Tokunaga   JOURNAL OF BIOCHEMISTRY

Peptide Level Immunoaffinity Enrichment Enhances Ubiquitination Site Identification on Individual Proteins

(2013) Veronica G. Anania et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

(2013) D. S. Kirkpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

(2009) J Silke et al.   CELL DEATH AND DIFFERENTIATION

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Impact of Peptide Abundance and Dynamic Range on Stable-Isotope-Based Quantitative Proteomic Analyses

(2008) Corey E. Bakalarski et al.   JOURNAL OF PROTEOME RESEARCH