The Nrf2 Pathway in Ischemic Stroke: A Review

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Cottonseed Oil Alleviates Ischemic Stroke-Induced Oxidative Stress Injury Via Activating the Nrf2 Signaling Pathway

(2021) Min Liu et al.   MOLECULAR NEUROBIOLOGY

Dimethyl fumarate attenuates 2-VO-induced vascular dementia via activating the Nrf2 signaling pathway in rats

(2021) Navneet Dhaliwal et al.   INFLAMMOPHARMACOLOGY

Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway

(2021) Chaoliang Tang et al.   Oxidative Medicine and Cellular Longevity

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke

(2021) Fangfang Bi et al.   Experimental and Therapeutic Medicine

Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification

(2020) Jun Wan Shin et al.   BIOCHEMICAL PHARMACOLOGY

Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats

(2020) Jing Yu et al.   Oxidative Medicine and Cellular Longevity

Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway

(2020) Dequan Liu et al.   Drug Design Development and Therapy

Management of acute ischemic stroke

(2020) Michael S Phipps et al.   BMJ-British Medical Journal

Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-κB and Nrf2/Keap-1 Signaling

(2020) Jianmei Gao et al.   ANTIOXIDANTS & REDOX SIGNALING

Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats

(2020) Fujiang Wang et al.   Frontiers in Pharmacology

Redox toxicology of environmental chemicals causing oxidative stress

(2020) Fuli Zheng et al.   Redox Biology

Pathophysiology of ischemic stroke: role of oxidative stress

(2020) Sofía Orellana-Urzúa et al.   CURRENT PHARMACEUTICAL DESIGN

Sulforaphane Elicits Protective Effects in Intestinal Ischemia Reperfusion Injury

(2020) Zhiquan Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selegiline (l-Deprenyl) Mitigated Oxidative Stress, Cognitive Abnormalities, and Histopathological Change in Rats: Alternative Therapy in Transient Global Ischemia

(2020) Mahroo Ahmari et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Potent Natural Antioxidant Carveol Attenuates MCAO-Stress Induced Oxidative, Neurodegeneration by Regulating the Nrf-2 Pathway

(2020) Imran Malik et al.   Frontiers in Neuroscience

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

(2020) Ángel Cores et al.   Biomolecules

Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Mitochondrial Dynamics/Mitophagy in Neurological Diseases

(2020) Tae-Cheon Kang   Antioxidants

Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins

(2020) Jia He et al.   Annals of Translational Medicine

Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats

(2020) Yixin Li et al.   BRAIN RESEARCH

Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives

(2020) Diji Kuriakose et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small molecules targeting cyclooxygenase/prostanoid cascade in experimental brain ischemia: Do they translate?

(2020) Jianxiong Jiang et al.   MEDICINAL RESEARCH REVIEWS

Sulforaphane alleviates ethanol-mediated central inhibition and reverses chronic stress-induced aggravation of acute alcoholism via targeting Nrf2-regulated catalase expression

(2020) Jun-Feng Xu et al.   NEUROPHARMACOLOGY

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

(2020) Dennis W. Choi   Frontiers in Neuroscience

Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke

(2020) Changjun Yang et al.   Frontiers in Neurology

A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation

(2020) Sha Liao et al.   Redox Biology

Critical Role of Nrf2 in Experimental Ischemic Stroke

(2019) Lei Liu et al.   Frontiers in Pharmacology

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

(2019) Jialin Duan et al.   Journal of Neuroinflammation

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

(2019) Ana I. Casas et al.   JOURNAL OF CLINICAL INVESTIGATION

DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by reducing inflammation and apoptosis via the activation of Nrf-2

(2019) Song Jianrong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway

(2019) Hui Wang et al.   ACS Chemical Neuroscience

Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2‐related factor 2 pathway

(2019) Yan‐Zhao Xie et al.   CNS Neuroscience & Therapeutics

Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways

(2019) Tao Ma et al.   Molecular Medicine Reports

Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential

(2019) Ardalan Zolnourian et al.   Oxidative Medicine and Cellular Longevity

Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis

(2019) Peng Wang et al.   NEUROSCIENCE

Neuroprotective effects of andrographolide derivative CX-10 in transient focal ischemia in rat: Involvement of Nrf2/AE and TLR/NF-κB signaling

(2019) Ming-Yan Yang et al.   PHARMACOLOGICAL RESEARCH

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

(2019) Pallab Shaw et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reactive Gliosis Contributes to Nrf2-Dependent Neuroprotection by Pretreatment with Dimethyl Fumarate or Korean Red Ginseng Against Hypoxic-Ischemia: Focus on Hippocampal Injury

(2019) Lei Liu et al.   MOLECULAR NEUROBIOLOGY

Tert-butylhydroquinone enhanced angiogenesis and astrocyte activation by activating nuclear factor-E2-related factor 2/heme oxygenase-1 after focal cerebral ischemia in mice

(2019) Yanxia Chen et al.   MICROVASCULAR RESEARCH

Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress

(2019) Ronggang Li et al.   Molecular Medicine Reports

Biochanin A Provides Neuroprotection Against Cerebral Ischemia/Reperfusion Injury by Nrf2-Mediated Inhibition of Oxidative Stress and Inflammation Signaling Pathway in Rats

(2019) Minmin Guo et al.   MEDICAL SCIENCE MONITOR

A novel biscoumarin compound ameliorates cerebral ischemia reperfusion-induced mitochondrial oxidative injury via Nrf2/Keap1/ARE signaling

(2019) Jun Wang et al.   NEUROPHARMACOLOGY

Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling

(2018) Wen Zhang et al.   ACTA PHARMACOLOGICA SINICA

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Resveratrol Treatment in Different Time-Attenuated Neuronal Apoptosis After Oxygen and Glucose Deprivation/Reoxygenation via Enhancing the Activation of Nrf-2 Signaling Pathway In Vitro

(2018) Jun Yang et al.   CELL TRANSPLANTATION

Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway

(2018) Yunyi Dai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways

(2018) Hailong Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway

(2018) Leilei Mao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain

(2018) Jingwei Shang et al.   Journal of Stroke & Cerebrovascular Diseases

Role of Nitric Oxide and Hydrogen Sulfide in Ischemic Stroke and the Emergent Epigenetic Underpinnings

(2018) Parimala Narne et al.   MOLECULAR NEUROBIOLOGY

Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2–VEGF Pathway

(2018) Hong Guo et al.   NEUROCHEMICAL RESEARCH

Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats

(2018) Juan Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats

(2018) Zhong-Yan Miao et al.   NEUROLOGICAL RESEARCH

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Korean Red Ginseng Pretreatment Protects Against Long-Term Sensorimotor Deficits After Ischemic Stroke Likely Through Nrf2

(2018) Lei Liu et al.   Frontiers in Cellular Neuroscience

Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain

(2018) Jingwei Shang et al.   Journal of Stroke & Cerebrovascular Diseases

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Oxidative and nitrosative stress in patients with ischemic stroke

(2018) Ozlem Dogan et al.   LaboratoriumsMedizin-Journal of Laboratory Medicine

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

(2018) Matej Sova et al.   Drug Design Development and Therapy

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism

(2018) Lei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH Oxidase-Related Pathophysiology in Experimental Models of Stroke

(2017) Hiroshi Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Time-dependent change of in vivo optical imaging of oxidative stress in a mouse stroke model

(2017) Yumiko Nakano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Stroke in ICD-11: the end of a long exile

(2017) Raad Shakir et al.   LANCET

The Ying and Yang of Adenosine A1 and A2A Receptors on ERK1/2 Activation in a Rat Model of Global Cerebral Ischemia Reperfusion Injury

(2017) Reham M. Atef et al.   MOLECULAR NEUROBIOLOGY

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation

(2017) Wei Zhang et al.   NEUROSCIENCE

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment

(2017) Violetta Krajka-Kuźniak et al.   Pharmacological Reports

Endoplasmic reticulum stress could induce autophagy and apoptosis and enhance chemotherapy sensitivity in human esophageal cancer EC9706 cells by mediating PI3K/Akt/mTOR signaling pathway

(2017) Fang Zhou et al.   TUMOR BIOLOGY

Blockage of cytosolic phospholipase A2 alpha by monoclonal antibody attenuates focal ischemic brain damage in mice

(2017) Hui Liu et al.   BioScience Trends

Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury

(2017) Xiu-Juan Gao et al.   Experimental and Therapeutic Medicine

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

(2017) Chun-Chun Wei et al.   Scientific Reports

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

(2017) Eri Kubo et al.   Scientific Reports

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

(2017) Joshua A. David et al.   Journal of Diabetes Research

Nrf2: a potential therapeutic target for diabetic neuropathy

(2017) Anil Kumar et al.   INFLAMMOPHARMACOLOGY

Synaptic Activity Protects Neurons Against Calcium-Mediated Oxidation and Contraction of Mitochondria During Excitotoxicity

(2017) Constanze Depp et al.   ANTIOXIDANTS & REDOX SIGNALING

Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory

(2017) Adchara Janyou et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex

(2016) Song liu et al.   BEHAVIOURAL BRAIN RESEARCH

Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo

(2016) Lan Zhang et al.   BRAIN RESEARCH

5-HMF attenuates striatum oxidative damage via Nrf2/ARE signaling pathway following transient global cerebral ischemia

(2016) Bai-liu Ya et al.   CELL STRESS & CHAPERONES

Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice

(2016) Ashok Jangra et al.   INFLAMMATION

Modulation of the peri-infarct neurogliovascular function by delayed COX-1 inhibition

(2016) Evelyn M.R. Lake et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats

(2016) Ruihe Lin et al.   Journal of Neuroinflammation

Protective effect of resveratrol against neuronal damage following transient global cerebral ischemia in mice

(2016) Jeong-Ho Hong et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R

(2016) Wei Li et al.   MICROVASCULAR RESEARCH

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke

(2016) Shuai Jiang et al.   MOLECULAR NEUROBIOLOGY

Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway

(2016) Chao Guo et al.   MOLECULAR NEUROBIOLOGY

β-Caryophyllene Attenuates Focal Cerebral Ischemia-Reperfusion Injury by Nrf2/HO-1 Pathway in Rats

(2016) Jie Lou et al.   NEUROCHEMICAL RESEARCH

Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway

(2016) Jiemeng Lin-Holderer et al.   NEUROPHARMACOLOGY

A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice

(2016) Keita Yamauchi et al.   NEUROSCIENCE

Tert-butylhydroquinone compromises survival in murine experimental stroke

(2016) Jiahong Sun et al.   NEUROTOXICOLOGY AND TERATOLOGY

Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke

(2016) Shihoko Kimura-Ohba et al.   Oxidative Medicine and Cellular Longevity

Look into brain energy crisis and membrane pathophysiology in ischemia and reperfusion

(2016) Maria Chomova et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Andrographolide stimulates p38 mitogen-activated protein kinase–nuclear factor erythroid-2-related factor 2–heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats

(2016) Ting-Lin Yen et al.   Translational Research

Gastrodia and Uncaria (tianma gouteng) water extract exerts antioxidative and antiapoptotic effects against cerebral ischemia in vitro and in vivo

(2016) Jia Wen Xian et al.   Chinese Medicine

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

(2016) Ralf A. Linker et al.   Therapeutic Advances in Chronic Disease

Tetramethylpyrazine inhibits neutrophil activation following permanent cerebral ischemia in rats

(2015) Cheng-Yi Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

(2015) Maria A. O’Connell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat model of transient global cerebral ischaemia

(2015) H. Lee et al.   BRITISH JOURNAL OF ANAESTHESIA

Dimethyl fumarate attenuates cerebral edema formation by protecting the blood–brain barrier integrity

(2015) Reiner Kunze et al.   EXPERIMENTAL NEUROLOGY

Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells

(2015) Li Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injuryin vitroandin vivo

(2015) Huanying Shi et al.   JOURNAL OF NEUROCHEMISTRY

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

(2015) Yizhi Liu et al.   JOURNAL OF NEUROSURGERY

Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in a rat model of cerebral ischemia

(2015) Shuangchan Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nrf2 facilitates repair of radiation induced DNA damage through homologous recombination repair pathway in a ROS independent manner in cancer cells

(2015) Sundarraj Jayakumar et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Neuroprotective effects of salidroside on focal cerebral ischemia/reperfusion injury involves the nuclear erythroid 2-related factor 2 pathway

(2015) Juan Hu et al.   Neural Regeneration Research

Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage

(2015) Loretta O. Iniaghe et al.   NEUROBIOLOGY OF DISEASE

Targeting thioredoxin-1 with siRNA exacerbates oxidative stress injury after cerebral ischemia/reperfusion in rats

(2015) L. Li et al.   NEUROSCIENCE

Resveratrol Preconditioning Protects Against Cerebral Ischemic Injury via Nuclear Erythroid 2–Related Factor 2

(2015) Srinivasan V. Narayanan et al.   STROKE

Dimethyl Fumarate Protects Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2

(2015) Xiurong Zhao et al.   STROKE

Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction

(2015) Yuanxue Gao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice

(2014) Yuan Zhao et al.   BRAIN RESEARCH BULLETIN

Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation by Sulforaphane

(2014) Z.-Y. Su et al.   Cancer Prevention Research

Mode of action and clinical studies with fumarates in multiple sclerosis

(2014) Anke Salmen et al.   EXPERIMENTAL NEUROLOGY

Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia–reperfusion injury

(2014) Toshinori Takagi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sevoflurane postconditioning attenuates cerebral ischemia-reperfusion injury via protein kinase B/nuclear factor-erythroid 2-related factor 2 pathway activation

(2014) Bo Li et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1

(2014) M. Zhang et al.   JOURNAL OF NEUROSCIENCE

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Danhong Injection Attenuates Ischemia/Reperfusion-Induced Brain Damage Which is Associating with Nrf2 Levels In Vivo and In Vitro

(2014) Hong Guo et al.   NEUROCHEMICAL RESEARCH

(−)-Epigallocatechin Gallate Protects Against Cerebral Ischemia-Induced Oxidative Stress via Nrf2/ARE Signaling

(2014) Jie Han et al.   NEUROCHEMICAL RESEARCH

Neuroprotective Effect of TAT-14-3-3ε Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats

(2014) Yuanjun Zhu et al.   PLoS One

Tert-Butylhydroquinone Alleviates Early Brain Injury and Cognitive Dysfunction after Experimental Subarachnoid Hemorrhage: Role of Keap1/Nrf2/ARE Pathway

(2014) Zhong Wang et al.   PLoS One

Sulforaphane Protects Rodent Retinas against Ischemia-Reperfusion Injury through the Activation of the Nrf2/HO-1 Antioxidant Pathway

(2014) Hong Pan et al.   PLoS One

Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine

(2014) Jiann-Hwa Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resveratrol inhibits the phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in the human chronic myeloid leukemia K562 cell line

(2014) TAO SUI et al.   Oncology Letters

Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Plant-Derived Compounds and Trace Minerals

(2014) Amanda Stefanson et al.   Nutrients

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models

(2013) Nilendra Singh et al.   ACS Chemical Neuroscience

Keap1-Nrf2 signaling pathway: Mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles

(2013) K. T. Turpaev   BIOCHEMISTRY-MOSCOW

Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia–reperfusion injury in vivo and in vitro

(2013) Bin Peng et al.   BRAIN RESEARCH

Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2013) Jian Zhang et al.   BRAIN RESEARCH BULLETIN

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

Lipoxygenase: An Emerging Target for Stroke Therapy

(2013) Klaus van Leyen   CNS & Neurological Disorders-Drug Targets

Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats

(2013) Tsung-Kuei Kao et al.   EXPERIMENTAL NEUROLOGY

Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood–brain barrier disruption and neurological deficits in stroke

(2013) Alessio Alfieri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erythropoietin activates Keap1–Nrf2/ARE pathway in rat brain after ischemia

(2013) Huaxing Meng et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Neohesperidin attenuates cerebral ischemia–reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway

(2013) Ji-Jun Wang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

(2013) Yang Bai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats

(2013) Cheng-Yi Chang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Temporal and spatial distribution of Nrf2 in rat brain following stroke: quantification of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique

(2013) Salil Srivastava et al.   JOURNAL OF PHYSIOLOGY-LONDON

Curcuminoids Limit Neutrophil-Mediated Reperfusion Injury in Experimental Stroke by Targeting the Endothelium

(2013) Janet L. Funk et al.   MICROCIRCULATION

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

(2013) Ramón Estruch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curcumin Protects Human Keratinocytes against Inorganic Arsenite-Induced Acute Cytotoxicity through an NRF2-Dependent Mechanism

(2013) Rui Zhao et al.   Oxidative Medicine and Cellular Longevity

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

(2013) Andrea Tarozzi et al.   Oxidative Medicine and Cellular Longevity

Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats

(2013) Susana González-Reyes et al.   Oxidative Medicine and Cellular Longevity

Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway

(2013) Jingxian Wu et al.   PLoS One

A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke

(2013) Niyaz Ahmad et al.   PROTOPLASMA

Physical Activity Frequency and Risk of Incident Stroke in a National US Study of Blacks and Whites

(2013) Michelle N. McDonnell et al.   STROKE

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

trans-Resveratrol Protects Ischemic PC12 Cells by Inhibiting the Hypoxia Associated Transcription Factors and Increasing the Levels of Antioxidant Defense Enzymes

(2012) Megha Agrawal et al.   ACS Chemical Neuroscience

The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression

(2012) Linyu Chen et al.   BRAIN RESEARCH

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways

(2012) Fabrício Simão et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The potential to intensify sulforaphane formation in cooked broccoli (Brassica oleracea var. italica) using mustard seeds (Sinapis alba)

(2012) Sameer Khalil Ghawi et al.   FOOD CHEMISTRY

Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance

(2012) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathophysiologic Cascades in Ischemic Stroke

(2012) Changhong Xing et al.   International Journal of Stroke

Dimethyl fumarate - only an anti-psoriatic medication?

(2012) Markus Meissner et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

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Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

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(2011) P. A. Egner et al.   Cancer Prevention Research

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Resveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats

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Sulforaphane protects brains against hypoxic–ischemic injury through induction of Nrf2-dependent phase 2 enzyme

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

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(2010) Hai-Dong Zhao   WORLD JOURNAL OF GASTROENTEROLOGY

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2009) Chenhui Yang et al.   BRAIN RESEARCH

Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons

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A pilot cross-over study to evaluate human oral bioavailability of BCM-95®CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin

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Efficacy and safety of fumaric acid esters in the long-term treatment of psoriasis – A retrospective study (FUTURE)

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Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

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Curcumin Improves Outcomes and Attenuates Focal Cerebral Ischemic Injury via Antiapoptotic Mechanisms in Rats

(2009) Jing Zhao et al.   NEUROCHEMICAL RESEARCH

Low Doses of Carbon Monoxide Protect Against Experimental Focal Brain Ischemia

(2009) Emil Zeynalov et al.   NEUROTOXICITY RESEARCH

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Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo: Implications for the Prevention of Fetal Alcohol Spectrum Disorders

(2008) Jian Dong et al.   ANTIOXIDANTS & REDOX SIGNALING

Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat

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Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats

(2008) Jing Zhao et al.   BRAIN RESEARCH

Multi-targeted prevention of cancer by sulforaphane

(2008) John D. Clarke et al.   CANCER LETTERS

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Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation

(2008) Camelia A. Danilov et al.   GLIA

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

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Anti-ischemic Effect of Curcumin in Rat Brain

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Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane

(2008) Li Kong et al.   NEUROCHEMISTRY INTERNATIONAL

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(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dose-Response Relationship Between Cigarette Smoking and Risk of Ischemic Stroke in Young Women

(2008) Viveca M. Bhat et al.   STROKE

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

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