Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2‐related factor 2 pathway

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke

(2018) Ewelina Kurtys et al.   CNS Neuroscience & Therapeutics

Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway

(2018) Leilei Mao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia

(2018) Elga Esposito et al.   JOURNAL OF NEUROCHEMISTRY

Gualou Guizhi Granule Protects Against Oxidative Injury by Activating Nrf2/ARE Pathway in Rats and PC12 Cells

(2018) Yuqin Zhang et al.   NEUROCHEMICAL RESEARCH

Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2–VEGF Pathway

(2018) Hong Guo et al.   NEUROCHEMICAL RESEARCH

Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice

(2018) Yang Yang et al.   NEUROSCIENCE LETTERS

Overexpression of adiponectin alleviates intracerebral hemorrhage-induced brain injury in rats via suppression of oxidative stress

(2018) Shaohua Wang et al.   NEUROSCIENCE LETTERS

Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats

(2018) Kpobari W. Nkpaa et al.   NEUROSCIENCE LETTERS

Sodium Tanshinone IIA Sulfonate Decreases Cigarette Smoke-Induced Inflammation and Oxidative Stress via Blocking the Activation of MAPK/HIF-1α Signaling Pathway

(2018) Ruijuan Guan et al.   Frontiers in Pharmacology

Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation

(2018) Tuo Yang et al.   Redox Biology

DPP-4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high-glucose conditions, potentially through the SIRT1/HIF-1/VEGF pathway

(2018) Dong-Hua Mi et al.   CNS Neuroscience & Therapeutics

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

(2018) Ligen Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation

(2017) Miaomiao Jia et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury

(2017) Raghavendar Chandran et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity

(2017) Qiu-Yan Zhang et al.   Oxidative Medicine and Cellular Longevity

Antioxidant and pro-angiogenic effects of corilagin in rat cerebral ischemia via Nrf2 activation

(2017) Yi Ding et al.   Oncotarget

Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis

(2017) Jichan Nie et al.   MEDICAL SCIENCE MONITOR

Leonurine Improves Age-Dependent Impaired Angiogenesis: Possible Involvement of Mitochondrial Function and HIF-1α Dependent VEGF Activation

(2017) Jia Qi et al.   Frontiers in Pharmacology

Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo

(2016) Lan Zhang et al.   BRAIN RESEARCH

Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain

(2016) Shahid Ali Shah et al.   CNS Neuroscience & Therapeutics

Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension

(2016) Liwen Li et al.   Scientific Reports

Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia

(2015) Jingru Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation

(2015) Wei-Ming Wang et al.   CNS Neuroscience & Therapeutics

Pleiotropic Role of PPARγin Intracerebral Hemorrhage: An Intricate System Involving Nrf2, RXR, and NF-κB

(2014) Xiu-Rong Zhao et al.   CNS Neuroscience & Therapeutics

Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2, Impacting Metabolic and Anti-oxidant Defenses

(2014) Chhanda Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCM-198 inhibits microglial overactivation and attenuates Aβ1-40-induced cognitive impairments in rats via JNK and NF-кB pathways

(2014) Zhen-Yi Hong et al.   Journal of Neuroinflammation

VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A in Vivo and in Vitro

(2013) Nicholas Beazley-Long et al.   AMERICAN JOURNAL OF PATHOLOGY

Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2013) Jian Zhang et al.   BRAIN RESEARCH BULLETIN

Melatonin modulates microsomal PGE synthase 1 and NF-E2-related factor-2-regulated antioxidant enzyme expression in LPS-induced murine peritoneal macrophages

(2013) M Aparicio-Soto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fumaric Acid Esters Stimulate Astrocytic VEGF Expression through HIF-1α and Nrf2

(2013) Diana Wiesner et al.   PLoS One

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

(2012) Kim A. Radermacher et al.   ANTIOXIDANTS & REDOX SIGNALING

SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways

(2012) Yanfei Zhang et al.   ATHEROSCLEROSIS

Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke

(2012) Haichao Liu et al.   BRAIN RESEARCH

Role of the vascular endothelium and plaque in acute ischemic stroke

(2012) J. A. Madden   NEUROLOGY

ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1

(2011) M. Sbroggio et al.   JOURNAL OF CELL SCIENCE

Oxidized Phospholipids Regulate Expression of ATF4 and VEGF in Endothelial Cells via NRF2-Dependent Mechanism: Novel Point of Convergence Between Electrophilic and Unfolded Protein Stress Pathways

(2010) Taras Afonyushkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leonurine Protects Middle Cerebral Artery Occluded Rats Through Antioxidant Effect and Regulation of Mitochondrial Function

(2010) Kok Poh Loh et al.   STROKE

Angiogenesis after cerebral ischemia

(2009) Heike Beck et al.   ACTA NEUROPATHOLOGICA