Keap1-Nrf2 signaling pathway: Mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Oxidant-Induced Cell Death and Nrf2-Dependent Antioxidative Response Are Controlled by Fra-1/AP-1

(2012) M. Vaz et al.   MOLECULAR AND CELLULAR BIOLOGY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure–activity relationship study

(2011) Kyril Turpaev et al.   BIOCHEMICAL PHARMACOLOGY

Mechanism of the Nrf2/Keap1/ARE signaling system

(2011) V. O. Tkachev et al.   BIOCHEMISTRY-MOSCOW

Modification of Keap1 Cysteine Residues by Sulforaphane

(2011) Chenqi Hu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transactivation of gene expression by NF-κB is dependent on thioredoxin reductase activity

(2011) Jacqueline M. Heilman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages

(2011) Kahina Abbas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury

(2011) Yanhong Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Src Subfamily Kinases Regulate Nuclear Export and Degradation of Transcription Factor Nrf2 to Switch Off Nrf2-mediated Antioxidant Activation of Cytoprotective Gene Expression

(2011) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

(2011) Michael B. Sporn et al.   JOURNAL OF NATURAL PRODUCTS

Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer

(2011) Kelsie L. Thu et al.   Journal of Thoracic Oncology

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells

(2011) Alexander V. Ivanov et al.   PLoS One

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

(2010) Albena T. Dinkova-Kostova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

(2010) Subash C. Gupta et al.   CANCER AND METASTASIS REVIEWS

Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia

(2010) Twee Tsao et al.   CANCER RESEARCH

Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation

(2010) Jeong-Eun Kim et al.   CELLULAR SIGNALLING

Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols

(2010) Albena T. Dinkova-Kostova et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Small molecule modulators of antioxidant response pathway

(2010) Wooyoung Hur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Caffeic acid phenethyl ester-mediated Nrf2 activation and IκB kinase inhibition are involved in NFκB inhibitory effect: Structural analysis for NFκB inhibition

(2010) Youna Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Exceptionally Potent Inducer of Cytoprotective Enzymes

(2010) Albena T. Dinkova-Kostova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ERK-MAPK Pathway Regulates Longevity through SKN-1 and Insulin-like Signaling inCaenorhabditis elegans

(2010) Tetsuya Okuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice andLeprdb/dbMice

(2010) Pradip K. Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Critical Role of Nitric Oxide Signaling, via ProteinS-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

(2010) Shigemoto Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell signaling mediated by nitrated cyclic guanine nucleotide

(2010) Takaaki Akaike et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Regulation of the expression of inducible nitric oxide synthase

(2010) Andrea Pautz et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

(2010) R. P. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrophilic tuning of the chemoprotective natural product sulforaphane

(2010) Y.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1

(2009) Aimee L. Eggler et al.   BIOCHEMICAL JOURNAL

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism

(2009) Dorrah Deeb et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

(2009) A.Kenneth MacLeod et al.   CARCINOGENESIS

Catechol Type Polyphenol Is a Potential Modifier of Protein Sulfhydryls: Development and Application of a New Probe for Understanding the Dietary Polyphenol Actions

(2009) Takeshi Ishii et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Stimulatory effect of benzylidenemalononitrile tyrphostins on expression of NO-dependent genes in U-937 monocytic cells

(2009) Kyril Turpaev et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of c-Jun phosphorylation in EpRE activation of phase II genes

(2009) Smadar Levy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1

(2009) Daigo Sumi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands as potential therapeutic agents to treat arthritis

(2009) Costas Giaginis et al.   PHARMACOLOGICAL RESEARCH

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One

Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure

(2009) Karen F. Chambers et al.   PROSTATE

Cross-talk between Transcription Factors AhR and Nrf2: Lessons for Cancer Chemoprevention from Dioxin

(2009) John D. Hayes et al.   TOXICOLOGICAL SCIENCES

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

(2009) Ronnie L. Yeager et al.   TOXICOLOGICAL SCIENCES

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

(2009) Madhurima Biswas et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 signaling and cell survival

(2009) Suryakant K. Niture et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure and physiological functions of the human peroxisome proliferator-activated receptor γ

(2008) Andrzej Zieleniak et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin

(2008) K. Liby et al.   CANCER RESEARCH

Prospective Type 1 and Type 2 Disulfides of Keap1 Protein

(2008) Ryan Holland et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Activation of Nrf2 in Defense against Cadmium-Induced Oxidative Stress†

(2008) Xiaoqing He et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

PPARα ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-κB and AP-1 pathways

(2008) Sriram Ramanan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis?

(2008) James M Kelley et al.   Journal of Neuroinflammation

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles

(2008) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Maf Proteins in Mammalian Gene Control: Mere Dimerization Partners or Dynamic Transcriptional Regulators?

(2007) Volker Blank   JOURNAL OF MOLECULAR BIOLOGY