Macrophage-targeted nanomedicine for chronic diseases immunotherapy

Brain-derived neurotrophic factor alleviates diabetes mellitus-accelerated atherosclerosis by promoting M2 polarization of macrophages through repressing the STAT3 pathway

(2020) Changlong Bi et al.   CELLULAR SIGNALLING

Biologically Responsive Plasmonic Assemblies for Second Near-Infrared Window Photoacoustic Imaging-Guided Concurrent Chemo-Immunotherapy

(2020) Rong Zhu et al.   ACS Nano

Obesity, Hypertension, and Cardiac Dysfunction

(2020) Alan J. Mouton et al.   CIRCULATION RESEARCH

The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy

(2020) Qiyao Yang et al.   Acta Pharmaceutica Sinica B

Endogenous ApoA-I expression in macrophages: A potential target for protection against atherosclerosis

(2020) Wujun Chen et al.   CLINICA CHIMICA ACTA

Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

(2020) Yihua Yang et al.   BIOMATERIALS

Nanotechnology for diagnosis and therapy of rheumatoid arthritis: Evolution towards theranostic approaches

(2020) Junkai Zhao et al.   CHINESE CHEMICAL LETTERS

Macrophage reprogramming for therapy

(2020) Valentina M. T. Bart et al.   IMMUNOLOGY

Mannose-Modified Liposome Co-Delivery of Human Papillomavirus Type 16 E7 Peptide and CpG Oligodeoxynucleotide Adjuvant Enhances Antitumor Activity Against Established Large TC-1 Grafted Tumors in Mice

(2020) Yan Zhao et al.   International Journal of Nanomedicine

The progress and perspective of strategies to improve tumor penetration of nanomedicines

(2020) Jiang Hu et al.   CHINESE CHEMICAL LETTERS

Histology and antitumor activity study of PTX-loaded micelle, a fluorescent drug delivery system prepared by PEG-TPP

(2019) Huilan Li et al.   CHINESE CHEMICAL LETTERS

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Dendritic cells modulate c-kit expression on the edge between activation and death

(2019) Sonia Simonetti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cy5.5-MSA-G250 nanoparticles (CMGNPs) induce M1 polarity of RAW264. 7 macrophage cells via TLR4-dependent manner

(2019) Zhuoxuan Lu et al.   CHINESE CHEMICAL LETTERS

Progress on Modulating Tumor‐Associated Macrophages with Biomaterials

(2019) Meilyn Sylvestre et al.   ADVANCED MATERIALS

Macrophage activation by a substituted pyrimido[5,4-b]indole increases anti-cancer activity

(2019) Joseph Hardie et al.   PHARMACOLOGICAL RESEARCH

Lyophilizable and Multifaceted Toll-like Receptor 7/8 Agonist-Loaded Nanoemulsion for the Reprogramming of Tumor Microenvironments and Enhanced Cancer Immunotherapy

(2019) Sun-Young Kim et al.   ACS Nano

Amplified Cancer Immunotherapy of a Surface-Engineered Antigenic Microparticle Vaccine by Synergistically Modulating Tumor Microenvironment

(2019) Hongjuan Zhao et al.   ACS Nano

Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions

(2019) Marina S. Dukhinova et al.   Nanomaterials

Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

(2019) Wei He et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery

(2019) Pan Zheng et al.   CHINESE CHEMICAL LETTERS

Deciphering the impact of PEG antifouling layer on surface attached functional peptides in regulating cell behaviors

(2019) Fu-Jian Xu   CHINESE CHEMICAL LETTERS

Mechanochemistry in cancer cell metastasis

(2018) Di Zhang et al.   CHINESE CHEMICAL LETTERS

Co-delivery of Andrographolide and Notch1-targeted siRNA to Macrophages with Polymer-based Nanocarrier for Enhanced Anti-inflammation

(2018) Teng Wu et al.   CHINESE JOURNAL OF POLYMER SCIENCE

Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer

(2018) Mirco Ponzoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b

(2018) Neha N. Parayath et al.   NANO LETTERS

High-density lipoprotein mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases

(2018) Song Ih Ahn et al.   Nano Research

Toxicity profiles of immunotherapy

(2018) S. Cousin et al.   PHARMACOLOGY & THERAPEUTICS

Macrophage-Targeted Therapeutics for Metabolic Disease

(2018) Kristin R. Peterson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Properties and functions of adipose tissue macrophages in obesity

(2018) Lucia Russo et al.   IMMUNOLOGY

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

(2018) Lutz Nuhn et al.   ADVANCED MATERIALS

M2b macrophage polarization and its roles in diseases

(2018) Le-xun Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Reprogramming Tumor-Associated Macrophages by Nanoparticle-Based Reactive Oxygen Species Photogeneration

(2018) Changrong Shi et al.   NANO LETTERS

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Sustained ocean changes contributed to sudden Antarctic sea ice retreat in late 2016

(2018) Gerald A. Meehl et al.   Nature Communications

CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer

(2018) Asim Pervaiz et al.   CELLULAR ONCOLOGY

Macrophage-specific nanotechnology-driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions

(2017) Perla Abigail Alvarado-Vazquez et al.   IMMUNOBIOLOGY

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of innate and adaptive immunity in obesity-associated metabolic disease

(2017) Tracey McLaughlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

(2017) Kely Campos Navegantes et al.   Journal of Translational Medicine

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy

(2017) Song Shen et al.   NANO LETTERS

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

CSF-1R Inhibitor Development: Current Clinical Status

(2017) Florent Peyraud et al.   Current Oncology Reports

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

Noninvasive Imaging of CD206-Positive M2 Macrophages as an Early Biomarker for Post-Chemotherapy Tumor Relapse and Lymph Node Metastasis

(2017) Chenran Zhang et al.   Theranostics

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape

(2017) Takuro Noguchi et al.   Cancer Immunology Research

Macrophage reaction against biomaterials in the mouse model – Phenotypes, functions and markers

(2016) R. Klopfleisch   Acta Biomaterialia

Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles

(2016) Kaylin M. McMahon et al.   ADVANCED FUNCTIONAL MATERIALS

B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients

(2016) Y. Yao et al.   CLINICAL CANCER RESEARCH

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi-Peptide Nanoparticles to Tumor-Associated Macrophages and Cancer Cells

(2015) João Conde et al.   ADVANCED FUNCTIONAL MATERIALS

The pathogenic role of angiogenesis in rheumatoid arthritis

(2015) Hatem A. Elshabrawy et al.   ANGIOGENESIS

Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis

(2015) Shardool Jain et al.   BIOMATERIALS

Neovascularization of the atherosclerotic plaque

(2015) Victor W.M. van Hinsbergh et al.   CURRENT OPINION IN LIPIDOLOGY

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

(2015) Geoffrey M Lynn et al.   NATURE BIOTECHNOLOGY

PEG modification on 111 In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques

(2015) Mikako Ogawa et al.   NUCLEAR MEDICINE AND BIOLOGY

The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model

(2015) Lingdong Quan et al.   PHARMACEUTICAL RESEARCH

Harnessing nanoparticles for immune modulation

(2015) Daniel R. Getts et al.   TRENDS IN IMMUNOLOGY

CCL18 from tumor-associated macrophages promotes angiogenesis in breast cancer

(2015) Ling Lin et al.   Oncotarget

Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer

(2015) Xianlei Sun et al.   Theranostics

Novel Markers to Delineate Murine M1 and M2 Macrophages

(2015) Kyle A. Jablonski et al.   PLoS One

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis

(2014) Hamed Laroui et al.   JOURNAL OF CONTROLLED RELEASE

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

(2014) Charles D. Mills et al.   Journal of Innate Immunity

Cancer-related inflammation and treatment effectiveness

(2014) Connie I Diakos et al.   LANCET ONCOLOGY

Biodistribution and in Vivo Activities of Tumor-Associated Macrophage-Targeting Nanoparticles Incorporated with Doxorubicin

(2014) Mengmeng Niu et al.   MOLECULAR PHARMACEUTICS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Interleukin-10 attenuation of collagen-induced arthritis is associated with suppression of interleukin-17 and retinoid-related orphan receptor γt production in macrophages and repression of classically activated macrophages

(2014) Liang Ye et al.   ARTHRITIS RESEARCH & THERAPY

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

(2014) Kae Won Cho et al.   Cell Reports

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells

(2014) Debbie C Strachan et al.   OncoImmunology

Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis

(2013) Janna A. van Diepen et al.   ATHEROSCLEROSIS

Selectively targeting the toll-like receptor 9 (TLR9) – IRF 7 signaling pathway by polymer blend particles

(2013) Helen C. Chen et al.   BIOMATERIALS

Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy

(2013) Bo Xiao et al.   BIOMATERIALS

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

(2013) Marie Jaguin et al.   CELLULAR IMMUNOLOGY

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

(2013) J. S. Orr et al.   DIABETES

Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4 + T Cells in Mice

(2013) David L. Morris et al.   DIABETES

Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease

(2013) Marnix A Lameijer et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Expression profiles of miRNAs in polarized macrophages

(2013) YINGYING ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis

(2013) So Jin Lee et al.   MOLECULAR THERAPY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Macrophages and chemokines as mediators of angiogenesis

(2013) Jennifer L. Owen et al.   Frontiers in Physiology

High-Density Lipoprotein Function, Dysfunction, and Reverse Cholesterol Transport

(2012) Edward A. Fisher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PET imaging of tumor associated macrophages using mannose coated 64Cu liposomes

(2012) Landon W. Locke et al.   BIOMATERIALS

Identifying Functional MicroRNAs in Macrophages with Polarized Phenotypes

(2012) Joel W. Graff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

(2012) Anders Etzerodt et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone

(2012) Jonas H Graversen et al.   MOLECULAR THERAPY

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection

(2012) Herwig Koppensteiner et al.   Retrovirology

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy

(2011) Zhen Huang et al.   JOURNAL OF CONTROLLED RELEASE

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

(2011) C.A. Ambarus et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

(2011) M. Spite et al.   JOURNAL OF IMMUNOLOGY

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

(2011) Anil Mahapatro et al.   JOURNAL OF NANOBIOTECHNOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages

(2010) C. A. Gleissner et al.   JOURNAL OF IMMUNOLOGY

Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment

(2010) Sang-Soo Kim et al.   MOLECULAR THERAPY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis

(2010) Rebecca Anderson et al.   ARTHRITIS RESEARCH & THERAPY

Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype

(2009) Joseph J. Boyle et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β

(2009) Taku Nagai et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Treatment of Experimental Arthritis with Stealth-Type Polymeric Nanoparticles Encapsulating Betamethasone Phosphate

(2009) T. Ishihara et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The safety of nanosized particles in titanium dioxide– and zinc oxide–based sunscreens

(2009) Marissa D. Newman et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Promoting Mechanisms of Vascular Health

(2009) Pedro R. Moreno et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TLR7 and TLR8 as targets in cancer therapy

(2008) M P Schön et al.   ONCOGENE

Macrophage activation by endogenous danger signals

(2007) X Zhang et al.   JOURNAL OF PATHOLOGY