Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

Hemodynamics and the Focal Origin of Atherosclerosis

(2010) PETER F. DAVIES et al.   Annals of the New York Academy of Sciences

Endothelial Atheroprotective and Anti-inflammatory Mechanisms

(2010) BRADFORD C. BERK et al.   Annals of the New York Academy of Sciences

microRNA: A Master Regulator of Cellular Processes for Bioengineering Systems

(2010) Wei Sun et al.   Annual Review of Biomedical Engineering

Matrix-Specific Protein Kinase A Signaling Regulates p21-Activated Kinase Activation by Flow in Endothelial Cells

(2010) Steven Daniel Funk et al.   CIRCULATION RESEARCH

Pathological Findings at Bifurcation Lesions

(2010) Gaku Nakazawa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth

(2010) K.-C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells

(2010) W. J. Rhee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells

(2010) X. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis

(2009) Douglas Nam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hemodynamically Driven Stent Strut Design

(2009) Juan M. Jiménez et al.   ANNALS OF BIOMEDICAL ENGINEERING

Advances in Cardiovascular Fluid Mechanics: Bench to Bedside

(2009) Lakshmi P. Dasi et al.   Annals of the New York Academy of Sciences

Flow Activation of AMP-Activated Protein Kinase in Vascular Endothelium Leads to Krüppel-Like Factor 2 Expression

(2009) Angela Young et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS

(2009) W. Wang et al.   BLOOD

Valves of the deep venous system: an overlooked risk factor

(2009) E. G. Brooks et al.   BLOOD

Is Virchow's triad complete?

(2009) P. A. Kyrle et al.   BLOOD

Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow

(2009) Anna Zampetaki et al.   CIRCULATION

Shear Stress Induces Synthetic-to-Contractile Phenotypic Modulation in Smooth Muscle Cells via Peroxisome Proliferator-Activated Receptor α/δ Activations by Prostacyclin Released by Sheared Endothelial Cells

(2009) Min-Chien Tsai et al.   CIRCULATION RESEARCH

The Subendothelial Extracellular Matrix Modulates JNK Activation by Flow

(2009) Cornelia Hahn et al.   CIRCULATION RESEARCH

Extracellular Matrix Differentiating Good Flow Versus Bad Flow

(2009) John Y.-J. Shyy   CIRCULATION RESEARCH

GTP Cyclohydrolase I Phosphorylation and Interaction With GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide

(2009) Li Li et al.   CIRCULATION RESEARCH

Retrograde Flow and Shear Rate Acutely Impair Endothelial Function in Humans

(2009) Dick H.J. Thijssen et al.   HYPERTENSION

Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow

(2009) Faisal Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)

(2009) Yuji Shimogonya et al.   JOURNAL OF BIOMECHANICS

Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited

(2009) Timothy Watson et al.   LANCET

Chronic Venous Insufficiency and Varicose Veins

(2009) Seshadri Raju et al.   NEW ENGLAND JOURNAL OF MEDICINE

eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues

(2009) J.-L. Balligand et al.   PHYSIOLOGICAL REVIEWS

Luminal Flow Amplifies Stent-Based Drug Deposition in Arterial Bifurcations

(2009) Vijaya B. Kolachalama et al.   PLoS One

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Arterial-Venous Differences in Tumor Necrosis Factor Responsiveness of Endothelial Cells by Anatomic Context

(2008) Meng Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

In vivo differences between endothelial transcriptional profiles of coronary and iliac arteries revealed by microarray analysis

(2008) Ji Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

(2008) James A. Thomas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis

(2008) Jeng-Jiann Chiu et al.   ANNALS OF MEDICINE

The Role of Hypoxia in Vascular Injury and Repair

(2008) Tony E. Walshe et al.   Annual Review of Pathology-Mechanisms of Disease

Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice

(2008) Reema Goel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice

(2008) Brian L. Harry et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

(2008) Joost O. Fledderus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human immunodeficiency virus per se exerts atherogenic effects

(2008) Ugo Oliviero et al.   ATHEROSCLEROSIS

Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

(2008) Kimio Satoh et al.   CIRCULATION

Cardiac Allograft Vasculopathy

(2008) Daniel Schmauss et al.   CIRCULATION

Endothelial Dysfunction and Cytomegalovirus Replication in Pediatric Heart Transplantation

(2008) Jacob Simmonds et al.   CIRCULATION

Deciphering the Endothelial Shear Stress Sensor

(2008) Robert E. Poelmann et al.   CIRCULATION

Atheroprotective Signaling Mechanisms Activated by Steady Laminar Flow in Endothelial Cells

(2008) Bradford C. Berk   CIRCULATION

Heparin-Binding Epidermal Growth Factor–Like Growth Factor Signaling in Flow-Induced Arterial Remodeling

(2008) Hua Zhang et al.   CIRCULATION RESEARCH

p21-Activated Kinase Signaling Regulates Oxidant-Dependent NF-κB Activation by Flow

(2008) A. Wayne Orr et al.   CIRCULATION RESEARCH

Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis

(2008) Mustafa Zakkar et al.   CIRCULATION RESEARCH

The Hydrodynamically Relevant Endothelial Cell Glycocalyx Observed In Vivo Is Absent In Vitro

(2008) Daniel R. Potter et al.   CIRCULATION RESEARCH

Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling

(2008) Peter J. Mack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KLF2-dependent, Shear Stress-induced Expression of CD59

(2008) Anne R. Kinderlerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation

(2008) Yunhao Liu et al.   JOURNAL OF CELL BIOLOGY

Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events

(2008) Adam E. Mullick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertension

(2008) John J. Bergan et al.   JOURNAL OF VASCULAR SURGERY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease

(2008) Jeppe Zacho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired glycocalyx barrier properties contribute to enhanced intimal low-density lipoprotein accumulation at the carotid artery bifurcation in mice

(2008) Bernard M. van den Berg et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of Coronary Blood Flow During Exercise

(2008) Dirk J. Duncker et al.   PHYSIOLOGICAL REVIEWS

Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis

(2007) Kim Van der Heiden et al.   ATHEROSCLEROSIS

Mechanisms in Experimental Venous Valve Failure and their Modification by Daflon© 500 mg

(2007) L. Pascarella et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Drug-eluting stent pathology—should we still be cautious?

(2007) Gaku Nakazawa et al.   Nature clinical practice. Cardiovascular medicine