In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation

(2014) Priyanka Nair-Gupta et al.   CELL

Conjugation of a TLR7 agonist and antigen enhances protection in the S. pneumoniae murine infection model

(2014) S. Vecchi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Designing and building the next generation of improved vaccine adjuvants

(2014) Luis A. Brito et al.   JOURNAL OF CONTROLLED RELEASE

Stimulation of Innate Immune Cells by Light-Activated TLR7/8 Agonists

(2014) Keun Ah Ryu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Rational design of small molecules as vaccine adjuvants

(2014) T. Y.- H. Wu et al.   Science Translational Medicine

Tuberculosis vaccines – rethinking the current paradigm

(2014) Peter Andersen et al.   TRENDS IN IMMUNOLOGY

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization

(2013) K. M. Quinn et al.   JOURNAL OF IMMUNOLOGY

Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice

(2013) Iraklis C. Kourtis et al.   PLoS One

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

(2013) A. de Titta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer

(2013) Ramon Arens et al.   SEMINARS IN IMMUNOLOGY

Characterization of chemically defined poly-N-isopropylacrylamide based copolymeric adjuvants

(2013) Akhilesh Kumar Shakya et al.   VACCINE

TLR4 ligand formulation causes distinct effects on antigen-specific cell-mediated and humoral immune responses

(2013) Christopher B. Fox et al.   VACCINE

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

(2012) Evan A. Scott et al.   BIOMATERIALS

The coiled coil motif in polymer drug delivery systems

(2012) Michal Pechar et al.   BIOTECHNOLOGY ADVANCES

Novel vaccine adjuvant LPS-Hydrogel for truncated basic fibroblast growth factor to induce antitumor immunity

(2012) Hua-shan Shi et al.   CARBOHYDRATE POLYMERS

Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes

(2012) Michael Y. Gerner et al.   IMMUNITY

DEC-205 is a cell surface receptor for CpG oligonucleotides

(2012) M. H. Lahoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Anchored Immunostimulatory Oligonucleotides for In Vivo Cell Modification and Localized Immunotherapy

(2011) Haipeng Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toward self-adjuvanting subunit vaccines: Model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines

(2011) Nikunj M. Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway

(2011) J. Z. Oh et al.   BLOOD

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

(2011) C. Russo et al.   BLOOD

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

(2011) Kathrin Kastenmüller et al.   JOURNAL OF CLINICAL INVESTIGATION

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

(2011) J. E. Epstein et al.   SCIENCE

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Hydrogel-Delivered GM-CSF Overcomes Nonresponsiveness to Hepatitis B Vaccine through the Recruitment and Activation of Dendritic Cells

(2010) H.-Y. Chou et al.   JOURNAL OF IMMUNOLOGY

Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues

(2010) Nikunj M. Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Beyond oncology — Application of HPMA copolymers in non-cancerous diseases☆

(2009) Xin-Ming Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators

(2009) Pernille Nordly et al.   Expert Opinion on Drug Delivery

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Assembling Peptide-Polymer Hydrogels Designed From the Coiled Coil Region of Fibrin

(2008) Peng Jing et al.   BIOMACROMOLECULES

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY