Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

Hypoxia and Hypoxia-Inducible Factor-1  Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

(2014) J. Jantsch et al.   JOURNAL OF IMMUNOLOGY

Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience

(2011) Ngayu Thairu et al.   ANGIOGENESIS

Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis

(2011) Monika Biniecka et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

(2011) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1  in Advanced Solid Tumors

(2011) S. Kummar et al.   CLINICAL CANCER RESEARCH

Treatment-Related Mortality With Bevacizumab in Cancer Patients

(2011) Vishal Ranpura et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

(2011) Jonathan Jantsch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Angiogenesis and blood vessel stability in inflammatory arthritis

(2010) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Knockout of HIF-1  in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

(2010) C. Werno et al.   CARCINOGENESIS

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

(2010) S. Rey et al.   CARDIOVASCULAR RESEARCH

CXCL12 gene expression is upregulated by hypoxia and growth arrest but not by inflammatory cytokines in rheumatoid synovial fibroblasts

(2010) Begoña Santiago et al.   CYTOKINE

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Prolyl Hydroxylase EGLN3 Regulates Skeletal Myoblast Differentiation through an NF-κB-dependent Pathway

(2010) Jian Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Significance of Serum Levels of Vascular Endothelial Growth Factor, Angiopoietin-1, and Angiopoietin-2 in Patients with Rheumatoid Arthritis

(2010) D. KUROSAKA et al.   JOURNAL OF RHEUMATOLOGY

Mechanism of Hypoxia-Induced NF- B

(2010) C. Culver et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint

(2009) M. Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Therapeutic Manipulation of the HIF Hydroxylases

(2009) Simon Nagel et al.   ANTIOXIDANTS & REDOX SIGNALING

Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice

(2009) Manuel J. del Rey et al.   ARTHRITIS AND RHEUMATISM

Inhibition of HIF-1α activity by BP-1 ameliorates adjuvant induced arthritis in rats

(2009) J. Shankar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response

(2009) Sally A Nicholas et al.   CELL RESEARCH

Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity

(2009) Jing Xue et al.   GASTROENTEROLOGY

The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1α prolyl hydroxylation

(2009) Sally A Nicholas et al.   IMMUNOLOGY AND CELL BIOLOGY

New insights in synovial angiogenesis

(2009) Zoltán Szekanecz et al.   JOINT BONE SPINE

Pleiotropic Effects of YC-1 Selectively Inhibit Pathological Retinal Neovascularization and Promote Physiological Revascularization in a Mouse Model of Oxygen-Induced Retinopathy

(2009) M. DeNiro et al.   MOLECULAR PHARMACOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Immature Blood Vessels in Rheumatoid Synovium Are Selectively Depleted in Response to Anti-TNF Therapy

(2009) Elena Izquierdo et al.   PLoS One

Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation

(2009) Carol A. Hitchon et al.   RHEUMATOLOGY INTERNATIONAL

Angiogenesis and its targeting in rheumatoid arthritis

(2009) Zoltán Szekanecz et al.   VASCULAR PHARMACOLOGY

The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis

(2009) Barbara Muz et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis

(2009) Mohammed A Akhavani et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases

(2009) Kathryn M Oliver et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxic synovial environment and expression of macrophage inflammatory protein 3γ/CCL20 in juvenile idiopathic arthritis

(2008) Maria Carla Bosco et al.   ARTHRITIS AND RHEUMATISM

The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: Critical role of interleukin-12p40

(2008) Nozomi Takahashi et al.   ARTHRITIS AND RHEUMATISM

Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: A nested, case-control study

(2008) Zurab Nadareishvili et al.   ARTHRITIS AND RHEUMATISM

Divergent effects of hypoxia on dendritic cell functions

(2008) A. Mancino et al.   BLOOD

The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors

(2008) Christina Warnecke et al.   EXPERIMENTAL CELL RESEARCH

Effects of hypoxia on transcription factor expression in human monocytes and macrophages

(2008) Laila Elbarghati et al.   IMMUNOBIOLOGY

Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts

(2008) H. Manabe et al.   INFLAMMATION RESEARCH

Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

(2008) Branavan Sivakumar et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Expression of hypoxia-inducible angiogenic proteins (hypoxia-inducible factor–1α, vascular endothelial growth factor, and E26 transformation-specific–1) and plaque hemorrhage in human carotid atherosclerosis

(2008) Tetsuhiro Higashida et al.   JOURNAL OF NEUROSURGERY

Interdependent roles for hypoxia inducible factor and nuclear factor-κB in hypoxic inflammation

(2008) Cormac T. Taylor   JOURNAL OF PHYSIOLOGY-LONDON

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Bevacizumab Improves the Overall and Progression-Free Survival of Patients with Metastatic Colorectal Cancer Treated with 5-Fluorouracil-Based Regimens Irrespective of Baseline Risk

(2008) Fairooz Kabbinavar et al.   ONCOLOGY

Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner

(2008) Seiko Oda et al.   PLoS One

Role of hypoxia-inducible factor-1  in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes

(2008) J. K. Ahn et al.   RHEUMATOLOGY

Signalling, inflammation and arthritis: NF- B and its relevance to arthritis and inflammation

(2008) R. E. Simmonds et al.   RHEUMATOLOGY

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY