The progress and perspective of strategies to improve tumor penetration of nanomedicines

Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy

(2020) Yazhe Wang et al.   ACS Applied Materials & Interfaces

Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo–Chemo Combination Therapy

(2020) Zhaoqing Cong et al.   ACS Nano

A NIR light triggered disintegratable nanoplatform for enhanced penetration and chemotherapy in deep tumor tissues

(2020) Xiang Xiong et al.   BIOMATERIALS

Advances in aggregatable nanoparticles for tumor-targeted drug delivery

(2020) Wenqi Yu et al.   CHINESE CHEMICAL LETTERS

pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy

(2020) Zhaoqing Shi et al.   CHINESE CHEMICAL LETTERS

Metformin-Induced Stromal Depletion to Enhance the Penetration of Gemcitabine-Loaded Magnetic Nanoparticles for Pancreatic Cancer Targeted Therapy

(2020) Haijie Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Size-Tunable Strategies for a Tumor Targeted Drug Delivery System

(2020) Wenqi Yu et al.   ACS Central Science

The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration

(2020) Xiaotong Yang et al.   Acta Pharmaceutica Sinica B

Size-adaptable and ligand (biotin)-sheddable nanocarriers equipped with avidin scavenging technology for deep tumor penetration and reduced toxicity

(2020) Ya Jin et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer

(2020) Rui Liu et al.   JOURNAL OF CONTROLLED RELEASE

iRGD targeted hybrid nanoparticles reverses multidrug resistant to effectively combat liver cancer

(2020) Jie Zhao et al.   JOURNAL OF DRUG TARGETING

Self-Reporting and Splitting Nanopomegranates Potentiate Deep Tissue Cancer Radiotherapy via Elevated Diffusion and Transcytosis

(2020) Li Wang et al.   ACS Nano

Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites

(2020) Jun Cao et al.   ADVANCED DRUG DELIVERY REVIEWS

Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity

(2020) Chuan Hu et al.   BIOMATERIALS

GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy

(2020) Congcong Lin et al.   Acta Pharmaceutica Sinica B

Enhancement of tumour penetration by nanomedicines through strategies based on transport processes and barriers

(2020) Huang Yang et al.   JOURNAL OF CONTROLLED RELEASE

Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect

(2019) Hangyi Wu et al.   Acta Pharmaceutica Sinica B

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

(2019) John D. Martin et al.   Annual Review of Physiology

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Development and application of hyaluronic acid in tumor targeting drug delivery

(2019) Zhijian Luo et al.   Acta Pharmaceutica Sinica B

Recent progress in drug delivery

(2019) Chong Li et al.   Acta Pharmaceutica Sinica B

Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis

(2019) Wenqi Yu et al.   BIOMATERIALS

Metal-organic framework-based nanomaterials for biomedical applications

(2019) Shu Zhang et al.   CHINESE CHEMICAL LETTERS

Transcytosis of Nanomedicine for Tumor Penetration

(2019) Yan Liu et al.   NANO LETTERS

Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery

(2019) Pan Zheng et al.   CHINESE CHEMICAL LETTERS

Charge-reversal nanocarriers: An emerging paradigm for smart cancer nanomedicine

(2019) Mingzhen Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Coadministration of iRGD with Multistage Responsive Nanoparticles Enhanced Tumor Targeting and Penetration Abilities for Breast Cancer Therapy

(2018) Chuan Hu et al.   ACS Applied Materials & Interfaces

Acid-Responsive Transferrin Dissociation and GLUT Mediated Exocytosis for Increased Blood-Brain Barrier Transcytosis and Programmed Glioma Targeting Delivery

(2018) Shaobo Ruan et al.   ADVANCED FUNCTIONAL MATERIALS

Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy

(2018) Chuan Hu et al.   BIOMATERIALS

Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes

(2018) Mingji Jin et al.   International Journal of Nanomedicine

Influence of the dissociation rate constant on the intra-tumor distribution of antibody-drug conjugate against tissue factor

(2018) Ryo Tsumura et al.   JOURNAL OF CONTROLLED RELEASE

Immunoliposomes in clinical oncology: State of the art and future perspectives

(2018) María Merino et al.   JOURNAL OF CONTROLLED RELEASE

Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers

(2018) Miaorong Yu et al.   Nature Communications

Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment

(2018) Rui Liu et al.   Acta Pharmaceutica Sinica B

The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system

(2018) Wei Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Normalizing Tumor Vessels To Increase the Enzyme-Induced Retention and Targeting of Gold Nanoparticle for Breast Cancer Imaging and Treatment

(2017) Wei Xiao et al.   MOLECULAR PHARMACEUTICS

Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy

(2017) Shu Yang et al.   PHARMACOLOGICAL RESEARCH

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation

(2016) Shaobo Ruan et al.   ACS Nano

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

(2016) Lei Miao et al.   ACS Nano

A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan

(2016) Xingli Cun et al.   Acta Biomaterialia

Shaping Tumor Microenvironment for Improving Nanoparticle Delivery

(2016) Huile Gao   CURRENT DRUG METABOLISM

The modulation of tumor vessel permeability by thalidomide and its impacts on different types of targeted drug delivery systems in a sarcoma mouse model

(2016) Dan Wang et al.   JOURNAL OF CONTROLLED RELEASE

Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue

(2016) Jimena G. Dancy et al.   JOURNAL OF CONTROLLED RELEASE

Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100 nm Particles

(2016) Yu Sakurai et al.   MOLECULAR THERAPY

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

A Novel Strategy through Combining iRGD Peptide with Tumor-Microenvironment-Responsive and Multistage Nanoparticles for Deep Tumor Penetration

(2015) Xingli Cun et al.   ACS Applied Materials & Interfaces

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

(2015) Shaobo Ruan et al.   BIOMATERIALS

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

(2015) Xinbing Sui et al.   MOLECULAR PHARMACEUTICS

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2015) Frank A Duca et al.   NATURE MEDICINE

Effect of Shape, Size, and Aspect Ratio on Nanoparticle Penetration and Distribution inside Solid Tissues Using 3D Spheroid Models

(2015) Rachit Agarwal et al.   Advanced Healthcare Materials

Brain-Penetrating Nanoparticles Improve Paclitaxel Efficacy in Malignant Glioma Following Local Administration

(2014) Elizabeth Nance et al.   ACS Nano

Targeting efficiency of RGD-modified nanocarriers with different ligand intervals in response to integrin αvβ3 clustering

(2014) Zhaoming Guo et al.   BIOMATERIALS

The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells

(2013) Golam Kibria et al.   BIOMATERIALS

Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct

(2013) Karin L. Lee et al.   Biomaterials Science

Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles

(2012) Erkki Ruoslahti   ADVANCED MATERIALS

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE