CSF-1R Inhibitor Development: Current Clinical Status

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

(2017) Michael F. Cuccarese et al.   Nature Communications

Abstract CT137: First-in-human study of AMG 820, a monoclonal anti-CSF-1R (c-fms) antibody, in patients (pts) with advanced solid tumors

(2016) Kyriakos Papadopoulos et al.   CANCER RESEARCH

A phase Ib study of pexidartinib (PLX3397) and weekly paclitaxel in patients with advanced solid tumors including an ovarian cancer subset

(2016) R. Wesolowski et al.   GYNECOLOGIC ONCOLOGY

CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

(2015) J. Escamilla et al.   CANCER RESEARCH

CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study

(2015) Philippe A Cassier et al.   LANCET ONCOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

(2015) William D. Tap et al.   NEW ENGLAND JOURNAL OF MEDICINE

T H 2-Polarized CD4 + T Cells and Macrophages Limit Efficacy of Radiotherapy

(2015) Stephen L. Shiao et al.   Cancer Immunology Research

Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma

(2015) Shin Foong Ngiow et al.   OncoImmunology

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs

(2014) P. P. Patwardhan et al.   CLINICAL CANCER RESEARCH

Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor

(2014) T. S. Kim et al.   CLINICAL CANCER RESEARCH

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells

(2014) Debbie C Strachan et al.   OncoImmunology

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

(2013) J. Xu et al.   CANCER RESEARCH

Pigmented villonodular synovitis: current concepts about diagnosis and management

(2013) Floortje GM Verspoor et al.   Future Oncology

Combining Radiotherapy and Cancer Immunotherapy: A Paradigm Shift

(2013) Silvia C. Formenti et al.   JNCI-Journal of the National Cancer Institute

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma

(2012) Han Chong Toh et al.   CANCER

Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway

(2012) W. Chen et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis

(2011) Philippe A. Cassier et al.   CANCER

Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis

(2011) Vinod Ravi et al.   CURRENT OPINION IN ONCOLOGY

Immune microenvironments in solid tumors: new targets for therapy

(2011) S. L. Shiao et al.   GENES & DEVELOPMENT

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer

(2010) Norio Nonomura et al.   BJU INTERNATIONAL

ABT-869 in Combination with Paclitaxel (P) as First-Line Treatment in Patients (Pts) with Advanced Breast Cancer.:

(2010) H. Rugo et al.   CANCER RESEARCH

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

The Tumor-Immune Microenvironment and Response to Radiation Therapy

(2010) Stephen L. Shiao et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Circulating Colony Stimulating Factor-1 and Breast Cancer Risk

(2008) R. M. Tamimi et al.   CANCER RESEARCH

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

(2008) Mark D. Murphey et al.   RADIOGRAPHICS

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE